Abstract:
:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed that lesion or inactivation of the secondary motor (M2) cortex disrupts learning of skilled movements. We tracked the endogenous promoter activity of the neuronal activity-regulated gene Arc in individual M2 neurons during rotarod learning by in vivo two-photon imaging of a knockin reporter. We found that task training initially recruits Arc-promoter-activated neurons and then consolidates them into a specific ensemble exhibiting persistent reactivation of Arc-promoter. The intensity of a neuron's initial Arc-promoter activation predicts its reactivation probability and neurons with weak initial Arc-promoter activation are dismissed from the ensemble during subsequent training. Our findings demonstrate a task-specific Arc-dependent cellular consolidation process in M2 cortex during motor learning.
journal_name
Neuronjournal_title
Neuronauthors
Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KHdoi
10.1016/j.neuron.2015.05.022subject
Has Abstractpub_date
2015-06-17 00:00:00pages
1385-92issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00429-8journal_volume
86pub_type
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