Abstract：
:The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excitatory (E-->E), but not when it was GABAergic, or inhibitory (E-->1). This target-specific action of BDNF was also found at divergent outputs of a single presynaptic neuron innervating both glutamatergic and GABAergic neurons, suggesting that individual terminals can be independently modified. Surprisingly, BDNF increased the frequency of miniature postsynaptic currents at both E-->E and E-->I, although it had no effect on evoked currents at E-->I. Finally, potentiation by neurotrophin-3 (NT-3) was also target specific. The selective effect at E-->E suggests that retrograde signaling by the postsynaptic target cell endows a localized presynaptic action of neurotrophins.
journal_name
Neuronjournal_title
Neuronauthors
Schinder AF,Berninger B,Poo Mdoi
10.1016/s0896-6273(00)80879-xsubject
Has Abstractpub_date
2000-01-01 00:00:00pages
151-63issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(00)80879-Xjournal_volume
25pub_type
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