Abstract：
:The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure. To dissect the chromatin remodeling versus platform function of CBP or the developmental versus adult role of this gene, we generated transgenic mice that express CBP in which HAT activity is eliminated. Acquisition of new information and short-term memory is spared in these mice, while the stabilization of short-term memory into long-term memory is impaired. The behavioral phenotype is due to an acute requirement for CBP HAT activity in the adult as it is rescued by both suppression of transgene expression or by administration of the histone deacetylase inhibitor Trichostatin A (TSA) in adult animals.
journal_name
Neuronjournal_title
Neuronauthors
Korzus E,Rosenfeld MG,Mayford Mdoi
10.1016/j.neuron.2004.06.002subject
Has Abstractpub_date
2004-06-24 00:00:00pages
961-72issue
6eissn
0896-6273issn
1097-4199pii
S0896627304003526journal_volume
42pub_type
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