Induction of spine growth and synapse formation by regulation of the spine actin cytoskeleton.

abstract：:Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...

journal_title：Neuron

authors： Ferguson JE,Jackson JC,Redish AD

更新日期：2011-04-14 00:00:00

abstract：:We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...

journal_title：Neuron

authors： Hasson U,Harel M,Levy I,Malach R

更新日期：2003-03-27 00:00:00

abstract：:Two studies in this issue of Neuron challenge widely held assumptions about the role of positive feedback in recurrent neuronal networks. Goldman shows that such feedback is not necessary for memory maintenance in a neural integrator, and Murphy and Miller show that it is not necessary for amplification of orientation...

journal_title：Neuron

authors： Ganguli S,Latham P

更新日期：2009-02-26 00:00:00

abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...

journal_title：Neuron

authors： McGinty VB,Lardeux S,Taha SA,Kim JJ,Nicola SM

更新日期：2013-06-05 00:00:00

abstract：:A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

journal_title：Neuron

authors： Carlson TA,He S

更新日期：2004-09-16 00:00:00

abstract：:Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...

journal_title：Neuron

authors： Churchland MM,Afshar A,Shenoy KV

更新日期：2006-12-21 00:00:00

abstract：:M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...

journal_title：Neuron

authors： Marrion NV

更新日期：1993-07-01 00:00:00

abstract：:Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...

journal_title：Neuron

authors： Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

更新日期：2017-05-03 00:00:00

abstract：:Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subs...

journal_title：Neuron

authors： Althaus AL,Parent JM

更新日期：2012-09-20 00:00:00

abstract：:Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline, rbp mutants have a ∼10-fold decrease in the apparent Ca(2+) sensitivity of release that we attribute to (1) impaired presynaptic Ca(2+) influx, (2) looser coupli...

journal_title：Neuron

authors： Müller M,Genç Ö,Davis GW

更新日期：2015-03-04 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synaptic plasticity and memory formation. Although significant progress has been made in understanding the role of postsynaptic CaMKII in synaptic plasticity, very little is known about its presynaptic functio...

journal_title：Neuron

authors： Ninan I,Arancio O

更新日期：2004-04-08 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We characterize AD stage-associated molecular networks by profiling 14,513 proteins and 34,173 phosphosites in the human brain with mass spectrometry, highlighting 173 protein changes in 17 pathways. The altered proteins are validated in two ...

journal_title：Neuron

authors： Bai B,Wang X,Li Y,Chen PC,Yu K,Dey KK,Yarbro JM,Han X,Lutz BM,Rao S,Jiao Y,Sifford JM,Han J,Wang M,Tan H,Shaw TI,Cho JH,Zhou S,Wang H,Niu M,Mancieri A,Messler KA,Sun X,Wu Z,Pagala V,High AA,Bi W,Zhan

更新日期：2020-03-18 00:00:00

abstract：:In this issue of Neuron, Rinberg et al. show that mice use a speed-accuracy tradeoff in odor discrimination. Shorter sampling results in high performance for easy problems, and enforced longer sampling results in higher accuracy for difficult problems, but mice freely choose intermediate sampling durations and accurac...

journal_title：Neuron

authors： Kay LM,Beshel J,Martin C

更新日期：2006-08-03 00:00:00

abstract：:Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin ...

journal_title：Neuron

authors： Ryan XP,Alldritt J,Svenningsson P,Allen PB,Wu GY,Nairn AC,Greengard P

更新日期：2005-07-07 00:00:00

abstract：:Recent studies indicate that dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) convey distinct signals. To explore this difference, we comprehensively identified each area's monosynaptic inputs using the rabies virus. We show that dopamine neurons in both areas integrate inp...

journal_title：Neuron

authors： Watabe-Uchida M,Zhu L,Ogawa SK,Vamanrao A,Uchida N

更新日期：2012-06-07 00:00:00

abstract：:Protrusive behavior of dendritic spines on developing neurons has been previously suggested to mediate the formation of new axodendritic synaptic contacts. A study by Zito et al. in this issue of Neuron links actin polymerization in dendritic spines with the motility that the spines exhibit and the synapses that they ...

journal_title：Neuron

authors： Dunaevsky A

更新日期：2004-10-14 00:00:00

abstract：:The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...

journal_title：Neuron

authors： Bennett C,Arroyo S,Hestrin S

更新日期：2013-10-16 00:00:00

abstract：:Neocortical excitatory and inhibitory neurons derive from distinct progenitor domains during embryonic development and migrate to their final positions, where they assemble into functional circuits. This process appears to be influenced by lineage relationships among locally born excitatory neurons, raising the intrig...

journal_title：Neuron

authors： Turrero García M,Mazzola E,Harwell CC

更新日期：2016-10-05 00:00:00

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...

journal_title：Neuron

authors： Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty A

更新日期：2010-04-29 00:00:00

abstract：:To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...

journal_title：Neuron

authors： Lewcock JW,Genoud N,Lettieri K,Pfaff SL

更新日期：2007-11-21 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs. The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which functions as translational repressor. We show that miR-125b and miR-132, as well as several other miRNAs, are associated with FMRP in mouse brain. miR...

journal_title：Neuron

authors： Edbauer D,Neilson JR,Foster KA,Wang CF,Seeburg DP,Batterton MN,Tada T,Dolan BM,Sharp PA,Sheng M

更新日期：2010-02-11 00:00:00

abstract：:Our tactile perception of external objects depends on skin-object interactions. The mechanics of contact dictates the existence of fundamental spatiotemporal input features-contact initiation and cessation, slip, and rolling contact-that originate from the fact that solid objects do not interpenetrate. However, it is ...

journal_title：Neuron

authors： Jörntell H,Bengtsson F,Geborek P,Spanne A,Terekhov AV,Hayward V

更新日期：2014-09-17 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:The mechanisms that constrain memory formation are of special interest because they provide insights into the brain's memory management systems and potential avenues for correcting cognitive disorders. RNAi knockdown in the Drosophila mushroom body neurons (MBn) of a newly discovered memory suppressor gene, Solute Car...

journal_title：Neuron

authors： Gai Y,Liu Z,Cervantes-Sandoval I,Davis RL

更新日期：2016-05-04 00:00:00

abstract：:Persistent neural activity that outlasts an initial stimulus is thought to provide a mechanism for the transient storage of memory. In this issue of Neuron, Fransén et al. identify important principles for a cell-autonomous mechanism of graded persistent firing using an elegant combination of experimental and computat...

journal_title：Neuron

authors： Dudman JT,Siegelbaum SA

更新日期：2006-03-02 00:00:00

abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...

journal_title：Neuron

authors： Sanchez GN,Sinha S,Liske H,Chen X,Nguyen V,Delp SL,Schnitzer MJ

更新日期：2015-12-16 00:00:00

abstract：:LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using genetic and biochemical studies involving Lrrk loss-of-function mutants and Parkinson-related LRRK2(G2019S) gain-of-kinase function, we sh...

journal_title：Neuron

authors： Matta S,Van Kolen K,da Cunha R,van den Bogaart G,Mandemakers W,Miskiewicz K,De Bock PJ,Morais VA,Vilain S,Haddad D,Delbroek L,Swerts J,Chávez-Gutiérrez L,Esposito G,Daneels G,Karran E,Holt M,Gevaert K,Moechars DW,De

更新日期：2012-09-20 00:00:00

abstract：:At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft, and postsynaptic specialization form a transcellular unit to enable efficient transmission of information between neurons. While we know much about the molecular machinery within each compartment, we are only beginning to u...

journal_title：Neuron

authors： Biederer T,Kaeser PS,Blanpied TA

更新日期：2017-11-01 00:00:00