Abstract:
:Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subset of DGCs in isolation is sufficient to cause epilepsy in a rodent.
journal_name
Neuronjournal_title
Neuronauthors
Althaus AL,Parent JMdoi
10.1016/j.neuron.2012.09.008subject
Has Abstractpub_date
2012-09-20 00:00:00pages
938-40issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00815-Xjournal_volume
75pub_type
评论,杂志文章相关文献
NEURON文献大全abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00410-x
更新日期:2001-09-13 00:00:00
abstract::In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2013.05.039
更新日期:2013-06-19 00:00:00
abstract::Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.07.001
更新日期:2005-07-21 00:00:00
abstract::In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.03.015
更新日期:2016-04-20 00:00:00
abstract::We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90152-x
更新日期:1994-01-01 00:00:00
abstract:VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.009
更新日期:2012-03-22 00:00:00
abstract::Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90145-6
更新日期:1988-05-01 00:00:00
abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90466-9
更新日期:1994-07-01 00:00:00
abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.07.012
更新日期:2018-08-22 00:00:00
abstract::The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.001
更新日期:2019-02-20 00:00:00
abstract::Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of contex...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.03.033
更新日期:2018-05-02 00:00:00
abstract::From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00278-1
更新日期:2001-04-01 00:00:00
abstract::We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00018-0
更新日期:2000-07-01 00:00:00
abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.10.035
更新日期:2018-11-07 00:00:00
abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90239-2
更新日期:1995-01-01 00:00:00
abstract::The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.08.019
更新日期:2007-09-20 00:00:00
abstract::A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80860-0
更新日期:1999-10-01 00:00:00
abstract::Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80373-6
更新日期:1997-09-01 00:00:00
abstract::To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.03.035
更新日期:2006-04-20 00:00:00
abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80032-5
更新日期:1999-08-01 00:00:00
abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.03.003
更新日期:2018-04-04 00:00:00
abstract::Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.04.023
更新日期:2008-06-12 00:00:00
abstract::In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.08.035
更新日期:2014-10-01 00:00:00
abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.05.028
更新日期:2017-06-07 00:00:00
abstract::In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.08.015
更新日期:2008-09-11 00:00:00
abstract::The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.025
更新日期:2006-02-16 00:00:00
abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2013.07.007
更新日期:2013-07-24 00:00:00
abstract::Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00500-2
更新日期:2003-08-14 00:00:00
abstract::Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.11.030
更新日期:2009-01-15 00:00:00
abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80760-6
更新日期:1999-05-01 00:00:00