Pten-less dentate granule cells make fits.

Abstract:

:Hippocampal dentate granule cell abnormalities are thought to play a causative role in temporal lobe epilepsy, but their precise contribution has not been dissociated from coexisting pathological changes. In this issue of Neuron, Pun et al. (2012) show, for the first time, that inducing proexcitatory changes in a subset of DGCs in isolation is sufficient to cause epilepsy in a rodent.

journal_name

Neuron

journal_title

Neuron

authors

Althaus AL,Parent JM

doi

10.1016/j.neuron.2012.09.008

subject

Has Abstract

pub_date

2012-09-20 00:00:00

pages

938-40

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(12)00815-X

journal_volume

75

pub_type

评论,杂志文章

相关文献

NEURON文献大全
  • Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication.

    abstract::We provide physiological, pharmacological, and structural evidence that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata. Antidromic activation of neighboring axons induced somatic spikel...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00410-x

    authors: Schmitz D,Schuchmann S,Fisahn A,Draguhn A,Buhl EH,Petrasch-Parwez E,Dermietzel R,Heinemann U,Traub RD

    更新日期:2001-09-13 00:00:00

  • Time finds its place in the hippocampus.

    abstract::In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2013.05.039

    authors: Rowland DC,Moser MB

    更新日期:2013-06-19 00:00:00

  • Phosphoinositide lipid second messengers: new paradigms for calcium channel modulation.

    abstract::Neuronal Ca2+ channels are key transducers coupling excitability to cellular function. As such, they are tightly regulated by multiple G protein-signaling pathways that finely tune their activity. In addition to fast, direct G(beta)gamma modulation of Ca2+ channels, a slower Galpha(q/11)-mediated mechanism has remaine...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2005.07.001

    authors: Delmas P,Coste B,Gamper N,Shapiro MS

    更新日期:2005-07-21 00:00:00

  • Crossover Inhibition Generates Sustained Visual Responses in the Inner Retina.

    abstract::In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.03.015

    authors: Rosa JM,Ruehle S,Ding H,Lagnado L

    更新日期:2016-04-20 00:00:00

  • How quickly can GABAA receptors open?

    abstract::We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90152-x

    authors: Maconochie DJ,Zempel JM,Steinbach JH

    更新日期:1994-01-01 00:00:00

  • Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.

    abstract:VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.02.009

    authors: Harwell CC,Parker PR,Gee SM,Okada A,McConnell SK,Kreitzer AC,Kriegstein AR

    更新日期:2012-03-22 00:00:00

  • cDNA clones coding for the structural subunit of a chicken brain nicotinic acetylcholine receptor.

    abstract::Nicotinic acetylcholine receptors (AChRs) immunoaffinity-purified from brains are composed of only two kinds of subunits rather than the four kinds present in muscle-type AChRs. Here we report the N-terminal protein sequences of the structural subunits of AChRs from rat and chicken brains and the cloning of full-lengt...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(88)90145-6

    authors: Schoepfer R,Whiting P,Esch F,Blacher R,Shimasaki S,Lindstrom J

    更新日期:1988-05-01 00:00:00

  • Synaptic augmentation by 5-HT at rested Aplysia sensorimotor synapses: independence of action potential prolongation.

    abstract::Short-term augmentation of synaptic transmission at sensory neuron synapses of Aplysia contributes to behavioral sensitization and is one of the current models for a cellular mechanism of learning. This neuromodulatory process, mediated at least in part by the facilitatory neurotransmitter serotonin (5-HT) acting thro...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(94)90466-9

    authors: Klein M

    更新日期:1994-07-01 00:00:00

  • A Mirror-Symmetric Excitatory Link Coordinates Odor Maps across Olfactory Bulbs and Enables Odor Perceptual Unity.

    abstract::Sensory input reaching the brain from bilateral and offset channels is nonetheless perceived as unified. This unity could be explained by simultaneous projections to both hemispheres, or inter-hemispheric information transfer between sensory cortical maps. Odor input, however, is not topographically organized, nor doe...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.07.012

    authors: Grobman M,Dalal T,Lavian H,Shmuel R,Belelovsky K,Xu F,Korngreen A,Haddad R

    更新日期:2018-08-22 00:00:00

  • Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.

    abstract::The frontline anti-malarial drug artemisinin and its derivatives have also been implicated in modulating multiple mammalian cellular pathways, including the recent identification of targeting γ-aminobutyric acid type A receptor (GABAAR) signaling in the pancreas. Their molecular mechanism of action, however, remains e...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.01.001

    authors: Kasaragod VB,Hausrat TJ,Schaefer N,Kuhn M,Christensen NR,Tessmer I,Maric HM,Madsen KL,Sotriffer C,Villmann C,Kneussel M,Schindelin H

    更新日期:2019-02-20 00:00:00

  • Distinct Accumbens Shell Output Pathways Promote versus Prevent Relapse to Alcohol Seeking.

    abstract::Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with drug self-administration promote relapse, whereas contexts associated with the absence of self-administration protect against relapse. The nucleus accumbens shell (AcbSh) is a key brain region determining these roles of contex...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.033

    authors: Gibson GD,Prasad AA,Jean-Richard-Dit-Bressel P,Yau JOY,Millan EZ,Liu Y,Campbell EJ,Lim J,Marchant NJ,Power JM,Killcross S,Lawrence AJ,McNally GP

    更新日期:2018-05-02 00:00:00

  • Prediction of orientation selectivity from receptive field architecture in simple cells of cat visual cortex.

    abstract::From the intracellularly recorded responses to small, rapidly flashed spots, we have quantitatively mapped the receptive fields of simple cells in the cat visual cortex. We then applied these maps to a feedforward model of orientation selectivity. Both the preferred orientation and the width of orientation tuning of t...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00278-1

    authors: Lampl I,Anderson JS,Gillespie DC,Ferster D

    更新日期:2001-04-01 00:00:00

  • Trajectory encoding in the hippocampus and entorhinal cortex.

    abstract::We recorded from single neurons in the hippocampus and entorhinal cortex (EC) of rats to investigate the role of these structures in navigation and memory representation. Our results revealed two novel phenomena: first, many cells in CA1 and the EC fired at significantly different rates when the animal was in the same...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)00018-0

    authors: Frank LM,Brown EN,Wilson M

    更新日期:2000-07-01 00:00:00

  • Unlocking the Potential for Endogenous Repair to Restore Sight.

    abstract::The eye often leads the way in the development of novel strategies for treating neurodegenerative disorders. Here, we highlight an exciting new study examining the potential for reactivating endogenous repair mechanisms and enabling the mammalian retina to repair itself. ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2018.10.035

    authors: Pearson RA,Ali RR

    更新日期:2018-11-07 00:00:00

  • Targeted disruption of Ca(2+)-calmodulin signaling in Drosophila growth cones leads to stalls in axon extension and errors in axon guidance.

    abstract::Ca(2+)-calmodulin (CaM) function was selectively disrupted in a specific subset of growth cones in transgenic Drosophila embryos in which a specific enhancer element drives the expression of the kinesin motor domain fused to a CaM antagonist peptide (kinesin-antagonist or KA, which blocks CaM binding to target protein...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/0896-6273(95)90239-2

    authors: VanBerkum MF,Goodman CS

    更新日期:1995-01-01 00:00:00

  • Cerebral responses to change in spatial location of unattended sounds.

    abstract::The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.08.019

    authors: Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

    更新日期:2007-09-20 00:00:00

  • Reelin is a ligand for lipoprotein receptors.

    abstract::A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80860-0

    authors: D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

    更新日期:1999-10-01 00:00:00

  • Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia.

    abstract::Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80373-6

    authors: Deiner MS,Kennedy TE,Fazeli A,Serafini T,Tessier-Lavigne M,Sretavan DW

    更新日期:1997-09-01 00:00:00

  • CaMKII activation in the entorhinal cortex disrupts previously encoded spatial memory.

    abstract::To investigate the role of the entorhinal cortex in memory at a molecular level, we developed transgenic mice in which transgene expression was inducible and limited to the superficial layers of the medial entorhinal cortex, pre- and parasubiculum. We found that expression of a constitutively active mutant form of CaM...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.03.035

    authors: Yasuda M,Mayford MR

    更新日期:2006-04-20 00:00:00

  • Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.

    abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)80032-5

    authors: Whistler JL,Chuang HH,Chu P,Jan LY,von Zastrow M

    更新日期:1999-08-01 00:00:00

  • An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.

    abstract::Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2018.03.003

    authors: Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

    更新日期:2018-04-04 00:00:00

  • Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex.

    abstract::Rapid, experience-dependent plasticity in developing visual cortex is thought to be competitive. After monocular visual deprivation, the reduction in response of binocular neurons to one eye is matched by a corresponding increase to the other. Chronic optical imaging in mice deficient in TNFalpha reveals the normal in...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.04.023

    authors: Kaneko M,Stellwagen D,Malenka RC,Stryker MP

    更新日期:2008-06-12 00:00:00

  • Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites.

    abstract::In cerebellar Purkinje cell dendrites, heterosynaptic calcium signaling induced by the proximal climbing fiber (CF) input controls plasticity at distal parallel fiber (PF) synapses. The substrate and regulation of this long-range dendritic calcium signaling are poorly understood. Using high-speed calcium imaging, we e...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2014.08.035

    authors: Otsu Y,Marcaggi P,Feltz A,Isope P,Kollo M,Nusser Z,Mathieu B,Kano M,Tsujita M,Sakimura K,Dieudonné S

    更新日期:2014-10-01 00:00:00

  • Inference in the Brain: Statistics Flowing in Redundant Population Codes.

    abstract::It is widely believed that the brain performs approximate probabilistic inference to estimate causal variables in the world from ambiguous sensory data. To understand these computations, we need to analyze how information is represented and transformed by the actions of nonlinear recurrent neural networks. We propose ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2017.05.028

    authors: Pitkow X,Angelaki DE

    更新日期:2017-06-07 00:00:00

  • Capitalizing on deep brain stimulation: thalamus as a language monitor.

    abstract::In this issue of Neuron, Wahl et al. demonstrate via invasive recordings from Deep Brain Stimulation leads that the thalamus (but not basal ganglia) is sensitive to certain linguistic violations, consistent with a subcortical role in selective recruitment of language-related cortical areas. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2008.08.015

    authors: Münte TF,Kutas M

    更新日期:2008-09-11 00:00:00

  • Task and content modulate amygdala-hippocampal connectivity in emotional retrieval.

    abstract::The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.12.025

    authors: Smith AP,Stephan KE,Rugg MD,Dolan RJ

    更新日期:2006-02-16 00:00:00

  • The expected value of control: an integrative theory of anterior cingulate cortex function.

    abstract::The dorsal anterior cingulate cortex (dACC) has a near-ubiquitous presence in the neuroscience of cognitive control. It has been implicated in a diversity of functions, from reward processing and performance monitoring to the execution of control and action selection. Here, we propose that this diversity can be unders...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2013.07.007

    authors: Shenhav A,Botvinick MM,Cohen JD

    更新日期:2013-07-24 00:00:00

  • Growing pains: the cytoskeleton as a critical regulator of pain plasticity.

    abstract::Inflammatory mediators act on peripheral sensory neurons to produce pain and hypersensitivity after tissue injury. In this issue of Neuron, Dina et al. report that inflammatory mediators, such as epinephrine and prostaglandins, appear to couple to specific G protein-coupled receptor signaling pathways through plastic ...

    journal_title:Neuron

    pub_type: 评论,杂志文章,评审

    doi:10.1016/s0896-6273(03)00500-2

    authors: Bhave G,Gereau RW 4th

    更新日期:2003-08-14 00:00:00

  • An Fgf8-dependent bistable cell migratory event establishes CNS asymmetry.

    abstract::Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated by the failure of the parapineal nucleus to migrate from its initial midline position to the ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2008.11.030

    authors: Regan JC,Concha ML,Roussigne M,Russell C,Wilson SW

    更新日期:2009-01-15 00:00:00

  • Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

    abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)80760-6

    authors: Ming G,Song H,Berninger B,Inagaki N,Tessier-Lavigne M,Poo M

    更新日期:1999-05-01 00:00:00