Abstract：
:Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axonal receptors following random vesicular release. Preminis are prominent in gabaergic synapses made by cerebellar interneurons during the development of the molecular layer. Unlike ordinary miniature postsynaptic currents in the same cells, premini frequencies are strongly enhanced by subthreshold depolarization, suggesting that the membrane depolarization they produce belongs to a feedback loop regulating neurotransmitter release. Thus, preminis could guide the formation of the interneuron network by enhancing neurotransmitter release at recently formed synaptic contacts.
journal_name
Neuronjournal_title
Neuronauthors
Trigo FF,Bouhours B,Rostaing P,Papageorgiou G,Corrie JE,Triller A,Ogden D,Marty Adoi
10.1016/j.neuron.2010.03.030subject
Has Abstractpub_date
2010-04-29 00:00:00pages
235-47issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00233-3journal_volume
66pub_type
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