Abstract：
:The prefrontal cortex (PFC) and anterior cingulate cortex (ACC) have both been implicated in cognitive control, but their relative roles remain unclear. Here we recorded the activity of single neurons in both areas while monkeys performed a task that required them to switch between trials in which they had to look toward a flashed stimulus (prosaccades) and trials in which they had to look away from the stimulus (antisaccades). We found that ACC neurons had a higher level of task selectivity than PFC neurons during the preparatory period on trials immediately following a task switch. In ACC neurons, task selectivity was strongest after the task switch and declined throughout the task block, whereas task selectivity remained constant in the PFC. These results demonstrate that the ACC is recruited when cognitive demands increase and suggest a role for both areas in task maintenance and the implementation of top-down control.
journal_name
Neuronjournal_title
Neuronauthors
Johnston K,Levin HM,Koval MJ,Everling Sdoi
10.1016/j.neuron.2006.12.023subject
Has Abstractpub_date
2007-02-01 00:00:00pages
453-62issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(06)01029-4journal_volume
53pub_type
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