Abstract:
:Rostrocaudal polarity of the tectum is first detectable at embryonic day 2 (E2) in the chick by the rostrocaudal gradient of en expression. When ectopic tectum is produced by heterotopic transplantation at E2 in the diencephalon, the gradient of en expression is inverted from the host polarity by environmental influences. Here we report that the retinal fibers project to the ectopic tectum in a topographic order in accord with the inverted gradient of en expression. Moreover, if ectopic tectum was produced at E3, when the en pattern was preserved, the retinotectal projection pattern was also in accord with the en pattern, suggesting that rostrocaudal polarity of retinotectal order follows en expression patterns.
journal_name
Neuronjournal_title
Neuronauthors
Itasaki N,Nakamura Hdoi
10.1016/0896-6273(92)90099-ysubject
Has Abstractpub_date
1992-04-01 00:00:00pages
787-98issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(92)90099-Yjournal_volume
8pub_type
杂志文章相关文献
NEURON文献大全abstract::A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90040-3
更新日期:1995-08-01 00:00:00
abstract::The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.024
更新日期:2016-01-06 00:00:00
abstract::Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives rise to balanced network dynamics is unknown. Here, we continuously monitored the statistics of network spiking in visual cortical circuits in freely behaving rats for 9 days. Under control conditions in light and dark, networks...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.08.031
更新日期:2019-11-20 00:00:00
abstract::Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90236-s
更新日期:1991-06-01 00:00:00
abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.10.032
更新日期:2012-01-12 00:00:00
abstract::Data on neuropsychiatric and behavioral genetics have attracted legal interest, as attorneys explore their use in criminal and civil cases. These developments may assist judges and juries in making difficult judgments-but they bring substantial risk of misinterpretation and misuse. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.026
更新日期:2014-06-04 00:00:00
abstract::Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.06.008
更新日期:2008-07-31 00:00:00
abstract::In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against any potentially threatening or damaging environmental inputs. By sensing noxious ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.07.016
更新日期:2007-08-02 00:00:00
abstract::Involvement of the cAMP cascade in Drosophila learning and memory is suggested by the aberrant behavioral phenotypes of the mutants dunce (cAMP phosphodiesterase) and rutabaga (adenylyl cyclase). Line DCO581, isolated via an enhancer detector screen for genes preferentially expressed in the mushroom bodies, contains a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90178-t
更新日期:1993-08-01 00:00:00
abstract::Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also regulates amyloid-β (Aβ) metabolism, aggregation, and deposition. Although earlier work suggests that different affinities of apoE isoforms to Aβ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2014.01.045
更新日期:2014-02-19 00:00:00
abstract::Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00200-9
更新日期:2003-05-08 00:00:00
abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00364-7
更新日期:2003-06-19 00:00:00
abstract::FLRTs are broadly expressed proteins with the unique property of acting as homophilic cell adhesion molecules and as heterophilic repulsive ligands of Unc5/Netrin receptors. How these functions direct cell behavior and the molecular mechanisms involved remain largely unclear. Here we use X-ray crystallography to revea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.008
更新日期:2014-10-22 00:00:00
abstract::A neural network can sustain and switch between different activity patterns to execute multiple behaviors. By monitoring the decision making for directional locomotion through motor circuit calcium imaging in behaving Caenorhabditis elegans (C. elegans), we reveal that C. elegans determines the directionality of movem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.09.005
更新日期:2011-11-17 00:00:00
abstract::Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90111-p
更新日期:1992-01-01 00:00:00
abstract::The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90182-q
更新日期:1993-08-01 00:00:00
abstract::Fluorescence imaging has enabled us to decipher spatiotemporal information coded in complex tissues. Genetically encoded probes that enable fluorescence imaging of excitable cell activity have been constructed by fusing fluorescent proteins to functional proteins that are involved in physiological signaling. The probe...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.10.003
更新日期:2005-10-20 00:00:00
abstract::alpha-Latrotoxin is a potent stimulator of neurosecretion. Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the presence of calcium ions. Therefore, the interaction of al...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80332-3
更新日期:1997-06-01 00:00:00
abstract::Although animal studies provided significant insights in understanding the neural basis of learning and adaptation, they often cannot dissociate between different learning mechanisms due to the lack of verbal communication. To overcome this limitation, we examined the mechanisms of learning and its limits in a human i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.02.012
更新日期:2019-05-08 00:00:00
abstract::The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2016.08.020
更新日期:2016-09-21 00:00:00
abstract::Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/close...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.023
更新日期:2007-10-04 00:00:00
abstract::Neural circadian pacemakers can be reset by light, and the resetting mechanism may involve cyclic nucleotide second messengers. We have examined pacemaker resetting and free-running activity rhythms in Drosophila dunce (dnc) and DC0 mutants, which identify a cAMP specific phosphodiesterase and the catalytic subunit of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90262-3
更新日期:1994-10-01 00:00:00
abstract::AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90175-y
更新日期:1991-05-01 00:00:00
abstract::The location, size, and number of synapses critically influence the specificity and strength of neural connections. In axons, synaptic vesicle (SV) and active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic loci. Little is known about the mechanisms coordinating presynapti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.04.035
更新日期:2013-06-19 00:00:00
abstract::Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.10.026
更新日期:2010-11-18 00:00:00
abstract::Circadian clocks consist of transcriptional feedback loops housed in interdependent pacemaker neurons. Yet little is known about the neuronal output components essential for rhythmic behavior. Drosophila mutants of a putative ion channel, narrow abdomen (na), exhibit poor circadian rhythms and suppressed daylight acti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.10.030
更新日期:2005-12-22 00:00:00
abstract::Alternative polyadenylation (APA) is increasingly recognized to regulate gene expression across different cell types, but obtaining APA maps from individual cell types typically requires prior purification, a stressful procedure that can itself alter cellular states. Here, we describe a new platform, cTag-PAPERCLIP, t...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.08.024
更新日期:2017-09-13 00:00:00
abstract::Experimental evidence shows that the inability to attribute mental states, such as desires and beliefs, to self and others (mentalizing) explains the social and communication impairments of individuals with autism. Brain imaging studies in normal volunteers highlight a circumscribed network that is active during menta...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00552-9
更新日期:2001-12-20 00:00:00
abstract::Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90260-2
更新日期:1989-09-01 00:00:00
abstract::Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.10.035
更新日期:2020-02-05 00:00:00