Abstract：
:Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying molecular mechanisms, we investigated the function of the active zone core component Bassoon in cerebellar mossy fiber to granule cell synapses. We show that short-term synaptic depression is enhanced in Bassoon knockout mice during sustained high-frequency trains but basal synaptic transmission is unaffected. Fluctuation and quantal analysis as well as quantification with constrained short-term plasticity models revealed that the vesicle reloading rate was halved in the absence of Bassoon. Thus, our data show that the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.
journal_name
Neuronjournal_title
Neuronauthors
Hallermann S,Fejtova A,Schmidt H,Weyhersmüller A,Silver RA,Gundelfinger ED,Eilers Jdoi
10.1016/j.neuron.2010.10.026subject
Has Abstractpub_date
2010-11-18 00:00:00pages
710-23issue
4eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00876-7journal_volume
68pub_type
杂志文章相关文献
NEURON文献大全abstract：:Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.11.038
更新日期：2006-01-19 00:00:00
abstract：:Melanin-concentrating hormone (MCH)-expressing neurons are key regulators of energy and glucose homeostasis. Here, we demonstrate that they provide dense projections to the median eminence (ME) in close proximity to tanycytes and fenestrated vessels. Chemogenetic activation of MCH neurons as well as optogenetic stimul...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.04.020
更新日期：2020-07-22 00:00:00
abstract：:Yang et al. (2016) show that transplantation of GABAergic inhibitory neurons into the amygdala boosts the persistence of fear extinction in mice. Transplantation was found to degrade perineuronal nets on endogenous inhibitory neurons and enhance synaptic plasticity in host amygdala. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.12.012
更新日期：2016-12-21 00:00:00
abstract：:Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.03.013
更新日期：2020-06-17 00:00:00
abstract：:The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2012.06.002
更新日期：2012-06-21 00:00:00
abstract：:Activity is known to be important for the refinement of neural connections in the developing brain. In this issue of Neuron, Hanson and Landmesser provide evidence that GABA-dependent spontaneous bursting of motor neurons in the embryonic spinal cord is required for the correct execution of an early axon pathfinding d...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/j.neuron.2004.08.027
更新日期：2004-09-02 00:00:00
abstract：:Neuronal microtubules support intracellular transport, facilitate axon growth, and form a basis for neuronal morphology. While microtubules in nonneuronal cells are depolymerized by cold, Ca(2+), or antimitotic drugs, neuronal microtubules are unusually stable. Such stability is important for normal axon growth and ma...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.01.036
更新日期：2013-04-10 00:00:00
abstract：:How a single fertilized cell generates diverse neuronal populations has been a fundamental biological problem since the 19(th) century. Classical histological methods revealed that postmitotic neurons are produced in a precise temporal and spatial order from germinal cells lining the cerebral ventricles. In the 20(th)...
journal_title：Neuron
pub_type： 历史文章,杂志文章
doi：10.1016/j.neuron.2011.05.005
更新日期：2011-05-26 00:00:00
abstract：:Diagnoses of behavioral disorders such as autism spectrum disorder and schizophrenia are based on symptomatic descriptions that have been difficult to connect to mechanism. Although psychiatric genetics provide insight into the genetic underpinning of such disorders, with a majority of cases explained by polygenic fac...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.03.021
更新日期：2018-04-18 00:00:00
abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.024
更新日期：2012-01-26 00:00:00
abstract：:A recent paper in Nature (Lim et al., 2012) describes the effects of melanocortin receptors in the nucleus accumbens. The studies connect a hypothalamic peptide system with brain reward centers and show effects on specific neuronal populations and behavioral components of mood. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2012.07.018
更新日期：2012-08-09 00:00:00
abstract：:Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2019.10.042
更新日期：2019-11-20 00:00:00
abstract：:Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2010.01.016
更新日期：2010-02-25 00:00:00
abstract：:Subiculum, the primary efferent pathway of hippocampus, participates in memory for spatial tasks, relapse to drug abuse, and temporal lobe seizures. Subicular pyramidal neurons exhibit low-threshold burst firing driven by a spike afterdepolarization. Here we report that burst firing can be regulated by stimulation of ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.12.013
更新日期：2009-01-29 00:00:00
abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2009.05.018
更新日期：2009-06-11 00:00:00
abstract：:The synaptic vesicle protein synaptotagmin I binds Ca2+ and is required for efficient neurotransmitter release. Here, we measure the response time of the C2 domains of synaptotagmin to determine whether synaptotagmin is fast enough to function as a Ca2+ sensor for rapid exocytosis. We report that synaptotagmin is "tun...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80850-8
更新日期：1999-10-01 00:00:00
abstract：:Memory encoding and retrieval require directional exchange of information between different areas in the medial temporal lobe. In this issue of Neuron, Koster et al. (2018) use high-resolution fMRI combined with state-of-the-art data analysis methods to trace the information flow in memory circuits in hippocampus and ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.09.004
更新日期：2018-09-19 00:00:00
abstract：:Memory and synaptic plasticity exhibit distinct temporal phases, with long-lasting forms distinguished by their dependence on macromolecular synthesis. Prevailing models for the molecular mechanisms underlying long-lasting synaptic plasticity have largely focused on transcriptional regulation. However, a growing body ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2004.09.013
更新日期：2004-09-30 00:00:00
abstract：:Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the perio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.05.013
更新日期：2004-06-10 00:00:00
abstract：:The dopamine D3 receptor is expressed primarily in regions of the brain that are thought to influence motivation and motor functions. To specify in vivo D3 receptor function, we generated mutant mice lacking this receptor. Our analysis indicates that in a novel environment, D3 mutant mice are transiently more active t...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80965-4
更新日期：1997-10-01 00:00:00
abstract：:Habits are notoriously difficult to break and, if broken, are usually replaced by new routines. To examine the neural basis of these characteristics, we recorded spike activity in cortical and striatal habit sites as rats learned maze tasks. Overtraining induced a shift from purposeful to habitual behavior. This shift...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.038
更新日期：2013-07-24 00:00:00
abstract：:The signaling mechanisms that control the survival of CNS neurons are poorly understood. Here we show that, in contrast to PNS neurons, the survival of purified postnatal rat retinal ganglion cells (RGCs) in vitro is not promoted by peptide trophic factors unless their intracellular cAMP is increased pharmacologically...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90172-8
更新日期：1995-10-01 00:00:00
abstract：:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90170-k
更新日期：1990-09-01 00:00:00
abstract：:Music can be seen as a model system for understanding gene × environment interactions and how these can influence neurocognitive development. The concept of musicality, however, is underspecified and not well understood. Here, I propose a framework for defining musicality to provide a foundation for studying the contr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.01.017
更新日期：2012-02-23 00:00:00
abstract：:In this perspective I tell the story (albeit a clearly abridged version) of how our knowledge of ion conduction through ion channels has evolved from a purely electrical concept to a structural dynamics view of ions interacting with a membrane protein. Our progress in this field has shown steady growth over the years ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.10.035
更新日期：2008-11-06 00:00:00
abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.02.040
更新日期：2016-04-06 00:00:00
abstract：:Argiotoxin, a component of the spider venom from Argiope lobata, blocks AMPA receptor channels expressed in homomeric and heteromeric configuration in Xenopus oocytes. Argiotoxin acts as an open channel blocker in a voltage-dependent manner and discriminates between the functionally diverse AMPA receptors. Importantly...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90061-u
更新日期：1993-06-01 00:00:00
abstract：:The primary visual cortex has a map of multiple visual parameters whose topographic relations remain poorly understood. A new study (Nauhaus et al., 2016) reveals a nearly geometric map-topography that coexists within a remarkably precise representation of visual space. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.08.001
更新日期：2016-08-17 00:00:00
abstract：:Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.03.010
更新日期：2007-04-05 00:00:00
abstract：:Locomotor activity in many species undergoes pronounced alterations in early postnatal life, and environmental cues may be responsible for modifying this process. To determine how these events are reflected in the nervous system, we studied rats reared under two different conditions-the presence or absence of gravity-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81164-2
更新日期：2000-05-01 00:00:00
