Abstract：
:We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic reticulum. The alpha 1 and alpha 2 subunits of the DHP receptor were colocalized in the junctional T-tubule membrane, supporting their proposed association in a functional complex and the possible participation of the alpha 2 subunit in excitation-contraction coupling. Ankyrin label in the triad showed a distribution different from that of the DHP receptor subunits. In addition, ankyrin was found in longitudinally oriented structures outside the triad. Thus, ankyrin might be involved in organizing the triad and in immobilizing integral membrane proteins in T-tubules and the sarcoplasmic reticulum.
journal_name
Neuronjournal_title
Neuronauthors
Flucher BE,Morton ME,Froehner SC,Daniels MPdoi
10.1016/0896-6273(90)90170-ksubject
Has Abstractpub_date
1990-09-01 00:00:00pages
339-51issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(90)90170-Kjournal_volume
5pub_type
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