Losing the lust for life: a new role for an old feeding Peptide?

abstract：:Adjustments in neural activity can drive cortical plasticity, but the underlying circuit components remain unclear. In this issue of Neuron, Barnes et al. (2015) show that visual deprivation-induced homeostatic plasticity invokes specific changes among select categories of V1 neurons. ...

journal_title：Neuron

authors： Seabrook TA,Huberman AD

更新日期：2015-06-03 00:00:00

abstract：:A proposal for an Australian Brain Initiative (ABI) is under development by members of the Australian Brain Alliance. Here we discuss the goals of the ABI, its areas of research focus, its context in the Australian research setting, and its necessity for ensuring continued success for Australian brain research. ...

journal_title：Neuron

authors： Australian Brain Alliance Steering Committee.

更新日期：2016-11-02 00:00:00

abstract：:Dopamine neurons in the ventral tegmental area (VTA) play an important role in the motivational systems underlying drug addiction, and recent work has suggested that they also release the excitatory neurotransmitter glutamate. To assess a physiological role for glutamate corelease, we disrupted the expression of vesic...

journal_title：Neuron

authors： Hnasko TS,Chuhma N,Zhang H,Goh GY,Sulzer D,Palmiter RD,Rayport S,Edwards RH

更新日期：2010-03-11 00:00:00

abstract：:Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase...

journal_title：Neuron

authors： Witten IB,Steinberg EE,Lee SY,Davidson TJ,Zalocusky KA,Brodsky M,Yizhar O,Cho SL,Gong S,Ramakrishnan C,Stuber GD,Tye KM,Janak PH,Deisseroth K

更新日期：2011-12-08 00:00:00

abstract：:Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...

journal_title：Neuron

authors： Wang BS,Sarnaik R,Cang J

更新日期：2010-01-28 00:00:00

abstract：:Although nitric oxide (NO) is produced by discrete groups of neurons in the brain, participation of NO in premotor structures directly involved in reflexively evoked, sensory-motor functions has not been demonstrated so far. We now show that NO is a physiological mediator in the generation of a specific motor response...

journal_title：Neuron

authors： Moreno-López B,Escudero M,Delgado-Garcia JM,Estrada C

更新日期：1996-10-01 00:00:00

abstract：:GABA, the major inhibitory neurotransmitter in the mammalian brain, binds to GABAA receptors, which form chloride ion channels. The predicted structure of the GABAA receptor places a consensus phosphorylation site for cAMP-dependent protein kinase (PKA) on an intracellular domain of the channel. Phosphorylation by var...

journal_title：Neuron

authors： Porter NM,Twyman RE,Uhler MD,Macdonald RL

更新日期：1990-12-01 00:00:00

abstract：:Insulin-like growth factor I (IGF-I) is a potent regulator of oligodendrocyte development and myelination in vitro, but its effect on myelination in vivo has never been tested directly. Therefore, we examined brain growth and myelination in a transgenic mouse line that overexpresses IGF-I. By postnatal day 55, when br...

journal_title：Neuron

authors： Carson MJ,Behringer RR,Brinster RL,McMorris FA

更新日期：1993-04-01 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...

journal_title：Neuron

authors： Sharma N,Deppmann CD,Harrington AW,St Hillaire C,Chen ZY,Lee FS,Ginty DD

更新日期：2010-08-12 00:00:00

abstract：:Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Fron...

journal_title：Neuron

authors： Johnson JO,Mandrioli J,Benatar M,Abramzon Y,Van Deerlin VM,Trojanowski JQ,Gibbs JR,Brunetti M,Gronka S,Wuu J,Ding J,McCluskey L,Martinez-Lage M,Falcone D,Hernandez DG,Arepalli S,Chong S,Schymick JC,Rothstein J,Landi

更新日期：2010-12-09 00:00:00

abstract：:Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin (mHTT) protein. There are currently no disease-modifying therapies available, but approaches that target proximally in disease pathogenesis hold gre...

journal_title：Neuron

authors： Tabrizi SJ,Ghosh R,Leavitt BR

更新日期：2019-03-06 00:00:00

abstract：:Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...

journal_title：Neuron

authors： Ménard C,Hein P,Paquin A,Savelson A,Yang XM,Lederfein D,Barnabé-Heider F,Mir AA,Sterneck E,Peterson AC,Johnson PF,Vinson C,Miller FD

更新日期：2002-11-14 00:00:00

abstract：:RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...

journal_title：Neuron

authors： Kanai Y,Dohmae N,Hirokawa N

更新日期：2004-08-19 00:00:00

abstract：:The retina adapts to average light intensity but also to the range of light intensities (contrast). A study by Baccus and Meister, in this issue of Neuron, identifies three ways that ganglion cells and interneurons adapt to high contrast: shorten integration time, reduce gain, and depolarize. Only the depolarization d...

journal_title：Neuron

authors： Demb JB

更新日期：2002-12-05 00:00:00

abstract：:Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...

journal_title：Neuron

authors： Xia J,Zhang X,Staudinger J,Huganir RL

更新日期：1999-01-01 00:00:00

abstract：:Apart from being a common feature of mental illness, auditory hallucinations provide an intriguing model for the study of internally generated sensory perceptions that are attributed to external sources. Until now, the knowledge about the cortical network that supports such hallucinations has been restricted by method...

journal_title：Neuron

authors： Dierks T,Linden DE,Jandl M,Formisano E,Goebel R,Lanfermann H,Singer W

更新日期：1999-03-01 00:00:00

abstract：:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...

journal_title：Neuron

authors： Salie R,Niederkofler V,Arber S

更新日期：2005-01-20 00:00:00

abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...

journal_title：Neuron

authors： Sanchez GN,Sinha S,Liske H,Chen X,Nguyen V,Delp SL,Schnitzer MJ

更新日期：2015-12-16 00:00:00

abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...

journal_title：Neuron

authors： Taha S,Hanover JL,Silva AJ,Stryker MP

更新日期：2002-10-24 00:00:00

abstract：:Animals must discern important stimuli and place them onto their cognitive map of their environment. The neocortex conveys general representations of sensory events to the hippocampus, and the hippocampus is thought to classify and sharpen the distinctions between these events. We recorded populations of dentate gyrus...

journal_title：Neuron

authors： Woods NI,Stefanini F,Apodaca-Montano DL,Tan IMC,Biane JS,Kheirbek MA

更新日期：2020-07-08 00:00:00

abstract：:Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel. A yeast two-hybrid screen with Slob as bait identifies the zeta isoform of 14-3-3 as a Slob-binding protein. Coimmunoprecipitation experiments from Drosophila heads and trans...

journal_title：Neuron

authors： Zhou Y,Schopperle WM,Murrey H,Jaramillo A,Dagan D,Griffith LC,Levitan IB

更新日期：1999-04-01 00:00:00

abstract：:We have devised a simple bioassay for the identification of molecules that inhibit growth cone motility. Chick dorsal root ganglion (DRG) growth cones extending on laminin collapse when exposed to a suspension of embryonic brain membranes. Detergent-solubilized membranes from which the detergent has been removed colla...

journal_title：Neuron

authors： Raper JA,Kapfhammer JP

更新日期：1990-01-01 00:00:00

abstract：:Recent progress in neurophysiological recording has developed in two directions. One relies on multimicroelectrodes to study correlations in neuron firing. The other relies on sophisticated tasks to distinguish successive stages of neuronal processing. In this issue of Neuron, Shichinohe et al. take this second approa...

journal_title：Neuron

authors： Schlag JD,Schlag-Rey M

更新日期：2009-06-11 00:00:00

abstract：:For efficient coding, sensory systems need to adapt to the distribution of signals to which they are exposed. In vision, natural scenes above and below the horizon differ in the distribution of chromatic and achromatic features. Consequently, many species differentially sample light in the sky and on the ground using ...

journal_title：Neuron

authors： Baden T,Schubert T,Chang L,Wei T,Zaichuk M,Wissinger B,Euler T

更新日期：2013-12-04 00:00:00

abstract：:Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...

journal_title：Neuron

authors： Mukamel EA,Schnitzer MJ

更新日期：2005-05-05 00:00:00

abstract：:Transmembrane channel-like (TMC) 1 and 2 are required for the mechanotransduction of mouse inner ear hair cells and localize to the site of mechanotransduction in mouse hair cell stereocilia. However, it remains unclear whether TMC1 and TMC2 are indeed ion channels and whether they can sense mechanical force directly....

journal_title：Neuron

authors： Jia Y,Zhao Y,Kusakizako T,Wang Y,Pan C,Zhang Y,Nureki O,Hattori M,Yan Z

更新日期：2020-01-22 00:00:00

abstract：:In this issue of Neuron, Issler et al. (2020) have identified the neuronal, long intergenic noncoding RNA LINC00473 as a potential molecular risk factor for the increased susceptibility for depression in females. ...

journal_title：Neuron

authors： Gururajan A

更新日期：2020-06-17 00:00:00

abstract：:Critical periods are developmental time windows during which neuronal connections are shaped by experience. In this issue of Neuron, Davis et al. (2015) show that transplantation of embryonic inhibitory interneurons can reactivate critical period plasticity and reverse amblyopia in the visual cortex of adult mice. ...

journal_title：Neuron

authors： Levine JN,Gu Y,Cang J

更新日期：2015-05-20 00:00:00

abstract：:L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...

journal_title：Neuron

authors： Burger PM,Mehl E,Cameron PL,Maycox PR,Baumert M,Lottspeich F,De Camilli P,Jahn R

更新日期：1989-12-01 00:00:00