Abstract：
:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participate in multiple acts of controlling neuronal circuit assembly. Depending on the cellular context, they can provide instructive signals at the growth cone or synapse or alternatively can elicit responses in the nucleus initiating transcriptional changes. Differences in signal transduction pathways may contribute to the diversity of the functional repertoire of these versatile molecules.
journal_name
Neuronjournal_title
Neuronauthors
Salie R,Niederkofler V,Arber Sdoi
10.1016/j.neuron.2005.01.002subject
Has Abstractpub_date
2005-01-20 00:00:00pages
189-92issue
2eissn
0896-6273issn
1097-4199pii
S0896627305000061journal_volume
45pub_type
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