Activity-dependent plasticity in an olfactory circuit.

Abstract:

:Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by focusing on the carbon dioxide (CO2) circuit in Drosophila. Specialized OSNs detect this gas and relay the information to a dedicated circuit in the brain. Prolonged exposure to CO2 induced a reversible volume increase in the CO2-specific glomerulus. OSNs showed neither altered morphology nor function after chronic exposure, but one class of inhibitory local interneurons showed significantly increased responses to CO2. Two-photon imaging of the axon terminals of a single PN innervating the CO2 glomerulus showed significantly decreased functional output following CO2 exposure. Behavioral responses to CO2 were also reduced after such exposure. We suggest that activity-dependent functional plasticity may be a general feature of the Drosophila olfactory system.

journal_name

Neuron

journal_title

Neuron

authors

Sachse S,Rueckert E,Keller A,Okada R,Tanaka NK,Ito K,Vosshall LB

doi

10.1016/j.neuron.2007.10.035

subject

Has Abstract

pub_date

2007-12-06 00:00:00

pages

838-50

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(07)00831-8

journal_volume

56

pub_type

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