Abstract:
:Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by focusing on the carbon dioxide (CO2) circuit in Drosophila. Specialized OSNs detect this gas and relay the information to a dedicated circuit in the brain. Prolonged exposure to CO2 induced a reversible volume increase in the CO2-specific glomerulus. OSNs showed neither altered morphology nor function after chronic exposure, but one class of inhibitory local interneurons showed significantly increased responses to CO2. Two-photon imaging of the axon terminals of a single PN innervating the CO2 glomerulus showed significantly decreased functional output following CO2 exposure. Behavioral responses to CO2 were also reduced after such exposure. We suggest that activity-dependent functional plasticity may be a general feature of the Drosophila olfactory system.
journal_name
Neuronjournal_title
Neuronauthors
Sachse S,Rueckert E,Keller A,Okada R,Tanaka NK,Ito K,Vosshall LBdoi
10.1016/j.neuron.2007.10.035subject
Has Abstractpub_date
2007-12-06 00:00:00pages
838-50issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00831-8journal_volume
56pub_type
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