Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons.


:AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a series of five agonists that produce rapidly desensitizing responses at non-NMDA receptors (EC50 1 microM to 4 mM) was similar to their equilibrium potency for block of kainate responses. Increasing the concentration of kainate overcame such block, but in the presence of AMPA the rate of activation of responses to kainate was slowed. Conversely, in the presence of kainate the amplitude of rapidly desensitizing responses evoked by AMPA was reduced, and the rate of onset of desensitization was slowed.






Patneau DK,Mayer ML




Has Abstract


1991-05-01 00:00:00
















  • GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.

    abstract::Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to d...


    pub_type: 杂志文章


    authors: Cruchaga C,Kauwe JS,Harari O,Jin SC,Cai Y,Karch CM,Benitez BA,Jeng AT,Skorupa T,Carrell D,Bertelsen S,Bailey M,McKean D,Shulman JM,De Jager PL,Chibnik L,Bennett DA,Arnold SE,Harold D,Sims R,Gerrish A,Williams J

    更新日期:2013-04-24 00:00:00

  • Functional topography of connections linking mirror-symmetric maps in the mouse olfactory bulb.

    abstract::In rodents, each main olfactory bulb contains two mirror-symmetric glomerular maps, a feature not found in the initial topographic maps of other sensory systems. Targeting tracer injections to identified glomeruli revealed that isofunctional odor columns-translaminar assemblies connected to a given glomerulus-were spe...


    pub_type: 杂志文章


    authors: Lodovichi C,Belluscio L,Katz LC

    更新日期:2003-04-24 00:00:00

  • To think or not to think: synaptic activity and Abeta release.

    abstract::Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neurona...


    pub_type: 评论,杂志文章,评审


    authors: Schroeder BE,Koo EH

    更新日期:2005-12-22 00:00:00

  • A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release.

    abstract::Although Caenorhabditis elegans has been utilized extensively to study synapse formation and function, relatively little is known about synaptic plasticity in C. elegans. We show that a brief treatment with the cholinesterase inhibitor aldicarb induces a form of presynaptic potentiation whereby ACh release at neuromus...


    pub_type: 杂志文章


    authors: Hu Z,Pym EC,Babu K,Vashlishan Murray AB,Kaplan JM

    更新日期:2011-07-14 00:00:00

  • Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.

    abstract::The embryonic basal ganglia generates multiple projection neurons and interneuron subtypes from distinct progenitor domains. Combinatorial interactions of transcription factors and chromatin are thought to regulate gene expression. In the medial ganglionic eminence, the NKX2-1 transcription factor controls regional id...


    pub_type: 杂志文章


    authors: Sandberg M,Flandin P,Silberberg S,Su-Feher L,Price JD,Hu JS,Kim C,Visel A,Nord AS,Rubenstein JLR

    更新日期:2016-09-21 00:00:00

  • Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.

    abstract::We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...


    pub_type: 杂志文章


    authors: Klaiber K,Williams N,Roberts TM,Papazian DM,Jan LY,Miller C

    更新日期:1990-08-01 00:00:00

  • Cascaded effects of spatial adaptation in the early visual system.

    abstract::Virtually all stages of the visual system exhibit adaptation: neurons adjust their responses based on the recent stimulus history. While some of these adjustments occur at specific stages, others may be inherited from earlier stages. How do adaptation effects cascade along the visual system? We measured spatially sele...


    pub_type: 杂志文章


    authors: Dhruv NT,Carandini M

    更新日期:2014-02-05 00:00:00

  • A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.

    abstract::DREADDs are chemogenetic tools widely used to remotely control cellular signaling, neuronal activity, and behavior. Here we used a structure-based approach to develop a new Gi-coupled DREADD using the kappa-opioid receptor as a template (KORD) that is activated by the pharmacologically inert ligand salvinorin B (SALB)...


    pub_type: 杂志文章


    authors: Vardy E,Robinson JE,Li C,Olsen RHJ,DiBerto JF,Giguere PM,Sassano FM,Huang XP,Zhu H,Urban DJ,White KL,Rittiner JE,Crowley NA,Pleil KE,Mazzone CM,Mosier PD,Song J,Kash TL,Malanga CJ,Krashes MJ,Roth BL

    更新日期:2015-05-20 00:00:00

  • Rapid remodeling of retinal arbors in the tectum with and without blockade of synaptic transmission.

    abstract::Dynamic rearrangements of axon terminal arbors may be critical for establishing appropriate connections in the developing nervous system. Here, the changes in complex retinal axon arbors in the tecta of live Xenopus larvae were followed during the formation of the topographic retinotectal projection. Three-dimensional...


    pub_type: 杂志文章


    authors: O'Rourke NA,Cline HT,Fraser SE

    更新日期:1994-04-01 00:00:00

  • Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions.

    abstract::Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing...


    pub_type: 杂志文章


    authors: Nguyen MD,Larivière RC,Julien JP

    更新日期:2001-04-01 00:00:00

  • Parkin and the molecular pathways of Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...


    pub_type: 杂志文章,评审


    authors: Giasson BI,Lee VM

    更新日期:2001-09-27 00:00:00

  • Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.

    abstract::Acute gene inactivation using short hairpin RNA (shRNA, knockdown) in developing brain is a powerful technique to study genetic function; however, discrepancies between knockdown and knockout murine phenotypes have left unanswered questions. For example, doublecortin (Dcx) knockdown but not knockout shows a neocortica...


    pub_type: 杂志文章


    authors: Baek ST,Kerjan G,Bielas SL,Lee JE,Fenstermaker AG,Novarino G,Gleeson JG

    更新日期:2014-06-18 00:00:00

  • In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum.

    abstract::Fibroblastic 3T3 and endocrine RIN cells were genetically modified by infection with a recombinant retrovirus encoding the form I of human tyrosine hydroxylase (TH) and selection in tyrosine-free medium. These cells were grafted to rats unilaterally lesioned with 6-hydroxy-dopamine. Both cell types survived implantati...


    pub_type: 杂志文章


    authors: Horellou P,Brundin P,Kalén P,Mallet J,Björklund A

    更新日期:1990-10-01 00:00:00

  • Abnormal functional organization in the dorsal lateral geniculate nucleus of mice lacking the beta 2 subunit of the nicotinic acetylcholine receptor.

    abstract::Spontaneous activity patterns in the developing retina appear important for the functional organization of the visual system. We show here that an absence of early retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor (nAChR) is associated with both gain and loss of functional organiz...


    pub_type: 杂志文章


    authors: Grubb MS,Rossi FM,Changeux JP,Thompson ID

    更新日期:2003-12-18 00:00:00

  • Short neuropeptide F is a sleep-promoting inhibitory modulator.

    abstract::To advance the understanding of sleep regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria. Rebound sleep following sleep deprivation is reduced by activation of sNPF neurons, and flies e...


    pub_type: 杂志文章


    authors: Shang Y,Donelson NC,Vecsey CG,Guo F,Rosbash M,Griffith LC

    更新日期:2013-10-02 00:00:00

  • A Role for the Superior Colliculus in Decision Criteria.

    abstract::Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal a...


    pub_type: 杂志文章


    authors: Crapse TB,Lau H,Basso MA

    更新日期:2018-01-03 00:00:00

  • Neural correlates of variations in event processing during learning in central nucleus of amygdala.

    abstract::Attention or variations in event processing help drive learning. Lesion studies have implicated the central nucleus of the amygdala (CeA) in this process, particularly when expected rewards are omitted. However, lesion studies cannot specify how information processing in CeA supports such learning. To address these qu...


    pub_type: 杂志文章


    authors: Calu DJ,Roesch MR,Haney RZ,Holland PC,Schoenbaum G

    更新日期:2010-12-09 00:00:00

  • Neural Architecture of Hunger-Dependent Multisensory Decision Making in C. elegans.

    abstract::Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans ...


    pub_type: 杂志文章


    authors: Ghosh DD,Sanders T,Hong S,McCurdy LY,Chase DL,Cohen N,Koelle MR,Nitabach MN

    更新日期:2016-12-07 00:00:00

  • Excitatory interactions between olfactory processing channels in the Drosophila antennal lobe.

    abstract::Each odorant receptor gene defines a unique type of olfactory receptor neuron (ORN) and a corresponding type of second-order neuron. Because each odor can activate multiple ORN types, information must ultimately be integrated across these processing channels to form a unified percept. Here, we show that, in Drosophila...


    pub_type: 杂志文章


    authors: Olsen SR,Bhandawat V,Wilson RI

    更新日期:2007-04-05 00:00:00

  • Modeling the spatial reach of the LFP.

    abstract::The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generati...


    pub_type: 杂志文章


    authors: Lindén H,Tetzlaff T,Potjans TC,Pettersen KH,Grün S,Diesmann M,Einevoll GT

    更新日期:2011-12-08 00:00:00

  • BOLD activity during mental rotation and viewpoint-dependent object recognition.

    abstract::We measured brain activity during mental rotation and object recognition with objects rotated around three different axes. Activity in the superior parietal lobe (SPL) increased proportionally to viewpoint disparity during mental rotation, but not during object recognition. In contrast, the fusiform gyrus was preferen...


    pub_type: 杂志文章


    authors: Gauthier I,Hayward WG,Tarr MJ,Anderson AW,Skudlarski P,Gore JC

    更新日期:2002-03-28 00:00:00

  • A Cre-dependent, anterograde transsynaptic viral tracer for mapping output pathways of genetically marked neurons.

    abstract::Neurotropic viruses that conditionally infect or replicate in molecularly defined neuronal subpopulations, and then spread transsynaptically, are powerful tools for mapping neural pathways. Genetically targetable retrograde transsynaptic tracer viruses are available to map the inputs to specific neuronal subpopulation...


    pub_type: 杂志文章


    authors: Lo L,Anderson DJ

    更新日期:2011-12-22 00:00:00

  • Task-guided selection of the dual neural pathways for reading.

    abstract::The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...


    pub_type: 杂志文章


    authors: Nakamura K,Hara N,Kouider S,Takayama Y,Hanajima R,Sakai K,Ugawa Y

    更新日期:2006-11-09 00:00:00

  • A monoclonal antibody that defines rostrocaudal gradients in the mammalian nervous system.

    abstract::Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...


    pub_type: 杂志文章


    authors: Suzue T,Kaprielian Z,Patterson PH

    更新日期:1990-10-01 00:00:00

  • Feedback inhibition by calcium limits the release of calcium by inositol trisphosphate in Limulus ventral photoreceptors.

    abstract::Injection of inositol 1,4,5 trisphosphate (InsP3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP3-induced elevation can be inhibited by a prior injection of calcium or InsP3 delivered 1 s earlier. Recovery from ...


    pub_type: 杂志文章


    authors: Payne R,Flores TM,Fein A

    更新日期:1990-04-01 00:00:00

  • Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus.

    abstract::Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...


    pub_type: 杂志文章


    authors: Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WF

    更新日期:2007-12-20 00:00:00

  • Learning How Neurons Fail Inside of Networks: Nonhuman Primates Provide Critical Data for Psychiatry.

    abstract::Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...


    pub_type: 杂志文章,评审


    authors: Heilbronner SR,Chafee MV

    更新日期:2019-04-03 00:00:00

  • A Meta-Analysis Suggests Different Neural Correlates for Implicit and Explicit Learning.

    abstract::A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...


    pub_type: 杂志文章,meta分析


    authors: Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

    更新日期:2017-10-11 00:00:00

  • The Mechanisms and Functions of Synaptic Facilitation.

    abstract::The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...


    pub_type: 杂志文章,评审


    authors: Jackman SL,Regehr WG

    更新日期:2017-05-03 00:00:00

  • Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons.

    abstract::The identification of surface proteins restricted to subsets of embryonic axons and growth cones may provide information on the mechanisms underlying axon fasciculation and pathway selection in the vertebrate nervous system. We describe here the characterization of a 135 kd cell surface glycoprotein, TAG-1, that is ex...


    pub_type: 杂志文章


    authors: Dodd J,Morton SB,Karagogeos D,Yamamoto M,Jessell TM

    更新日期:1988-04-01 00:00:00