Abstract:
:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation of presynaptic specializations, but not preganglionic axonal ingrowth from the spinal cord into sympathetic ganglia. We also find that NGF-TrkA signaling endosomes travel from distal axons to cell bodies and dendrites where they promote PSD clustering. Furthermore, the p75 neurotrophin receptor restricts PSD formation, suggesting an important role for antagonistic NGF-TrkA and p75 signaling pathways during retrograde control of synapse establishment. Thus, in addition to defining the appropriate number of sympathetic neurons that survive the period of developmental cell death, target-derived NGF also exerts control over the degree of connectivity between the spinal cord and sympathetic ganglia through retrograde control of synapse assembly.
journal_name
Neuronjournal_title
Neuronauthors
Sharma N,Deppmann CD,Harrington AW,St Hillaire C,Chen ZY,Lee FS,Ginty DDdoi
10.1016/j.neuron.2010.07.018subject
Has Abstractpub_date
2010-08-12 00:00:00pages
422-34issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(10)00556-8journal_volume
67pub_type
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