Abstract：
:After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in synaptic transmission only during tetanic stimulation). Labeling endocytosed vesicular structures with a fluorescent styryl dye, FM1-43, and measuring intracellular Ca2+ concentrations with a Ca2+ indicator, rhod-2, we show here that the ECP is replenished by SVs endocytosed during stimulation, and this process depends on external Ca2+. In contrast, the RP is refilled after cessation of tetanus by a process mediated by Ca2+ released from internal stores.
journal_name
Neuronjournal_title
Neuronauthors
Kuromi H,Kidokoro Ydoi
10.1016/s0896-6273(02)00777-8subject
Has Abstractpub_date
2002-07-18 00:00:00pages
333-43issue
2eissn
0896-6273issn
1097-4199pii
S0896627302007778journal_volume
35pub_type
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