Abstract:
:Recent reports have overturned a series of dogmas that have been well entrenched in the neuroscience literature concerning NMDA-type glutamate receptors (NMDARs). The new data show that NMDARs exist on the myelin sheath formed by oligodendrocytes, that an uncompetitive NMDAR antagonist has successfully passed human clinical trials, and that NMDARs trigger multiple deleterious cascades to inflict cellular damage on both neurons and glia during cerebral ischemia (stroke). These recent findings bode well for clinical intervention with NMDAR antagonists in more neurological disorders than previously thought, including multiple sclerosis, cerebral palsy (periventricular leukomalacia), and spinal cord injury.
journal_name
Neuronjournal_title
Neuronauthors
Lipton SAdoi
10.1016/j.neuron.2006.03.026subject
Has Abstractpub_date
2006-04-06 00:00:00pages
9-11issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00223-6journal_volume
50pub_type
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