Abstract：
:Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper of goal-directed behavior. Here we report that extracellular DA increases induced by selective optogenetic activation of cholinergic neurons in the nucleus accumbens (NAc) are inhibited by CB1 agonists and eCBs. This modulation requires CB1 receptors on cortical glutamatergic afferents. Dopamine increases driven by optogenetic activation of prefrontal cortex (PFC) terminals in the NAc are similarly modulated by activation of these CB1 receptors. We further demonstrate that this same population of CB1 receptors modulates optical self-stimulation sustained by activation of PFC afferents in the NAc. These results establish local eCB actions on PFC terminals within the NAc that inhibit mesolimbic DA release and constrain reward-driven behavior.
journal_name
Neuronjournal_title
Neuronauthors
Mateo Y,Johnson KA,Covey DP,Atwood BK,Wang HL,Zhang S,Gildish I,Cachope R,Bellocchio L,Guzmán M,Morales M,Cheer JF,Lovinger DMdoi
10.1016/j.neuron.2017.11.012subject
Has Abstractpub_date
2017-12-06 00:00:00pages
1112-1126.e5issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(17)31065-6journal_volume
96pub_type
杂志文章相关文献
NEURON文献大全abstract：:To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminus of A beta 1-40, whil...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(94)90458-8
更新日期：1994-07-01 00:00:00
abstract：:Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.02.018
更新日期：2018-03-07 00:00:00
abstract：:In the mammalian olfactory bulb, signal processing is mediated by synaptic interactions between dendrites. Glutamate released from mitral cell dendrites excites dendritic spines of granule cells, which in turn release GABA back onto the mitral cell dendrites, forming a reciprocal synaptic pair. This feedback synaptic ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)81065-x
更新日期：2000-03-01 00:00:00
abstract：:Calcium/calmodulin kinase II (CaMKII) is required for LTP and experience-dependent potentiation in the barrel cortex. Here, we find that whisker deprivation increases LTP in the layer IV to II/III pathway and that PKA antagonists block the additional LTP. No LTP was seen in undeprived CaMKII-T286A mice, but whisker de...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.10.018
更新日期：2008-12-10 00:00:00
abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2009.06.026
更新日期：2009-08-13 00:00:00
abstract：:The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates many fundamental brain functions. Studies in humans have suggested that strong LC activation might shift network connectivity to favor salience processing. To causally test this hypothesis, we use a mouse model to study the eff...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.05.034
更新日期：2019-08-21 00:00:00
abstract：:Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs) can affect transmission not only by changing neurotransmitter release probability, but also by shaping short-term plasticity (STP). Indeed, changes in STP are ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.07.030
更新日期：2018-09-05 00:00:00
abstract：:The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu's laboratory (Cui et al., 2018; Yang et al., 2018) showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2018.05.032
更新日期：2018-06-06 00:00:00
abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.043
更新日期：2015-12-02 00:00:00
abstract：:Advancing psychiatry requires understanding brain malfunction at a microscopic scale, where neurons and synapses operate under constraints imposed by behavior, cognition, and neural architecture. Nonhuman primates are unmatched in approximating the structural and computational environment of the human brain. ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2019.02.030
更新日期：2019-04-03 00:00:00
abstract：:Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.01.022
更新日期：2006-02-16 00:00:00
abstract：:We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90139-7
更新日期：1990-06-01 00:00:00
abstract：:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00465-3
更新日期：2003-08-28 00:00:00
abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.010
更新日期：2013-06-05 00:00:00
abstract：:The primary motor cortex (MI) is regarded as the site for motor control. Occasional reports that MI neurons react to sensory stimuli have either been ignored or attributed to guidance of voluntary movements. Here, we show that MI activation is necessary for the somatic perception of movement of our limbs. We made use ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00980-7
更新日期：2002-12-05 00:00:00
abstract：:Neural circuits consist of highly precise connections among specific types of neurons that serve a common functional goal. How neurons distinguish among different synaptic targets to form functionally precise circuits remains largely unknown. Here, we show that during development, the adhesion molecule cadherin-6 (Cdh...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.07.006
更新日期：2011-08-25 00:00:00
abstract：:The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated th...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.04.040
更新日期：2017-05-17 00:00:00
abstract：:The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.07.023
更新日期：2006-10-19 00:00:00
abstract：:Building on Canada's strong traditions in neuroscience and ethics, neuroethics provides a backbone for the evolving Canadian Brain Research Strategy (CBRS) that, from the outset, incorporates ethically responsible discoveries in brain science into clinical, societal, educational, and commercial innovation. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.12.021
更新日期：2019-02-06 00:00:00
abstract：:Classical patterning molecules that were previously implicated in controlling cell fate choices in the nervous system have recently been shown to play additional roles in axon guidance and synaptogenesis. Bone morphogenetic proteins (BMPs), Sonic hedgehog (Shh), Wnts, and fibroblast growth factors (FGFs) all participa...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2005.01.002
更新日期：2005-01-20 00:00:00
abstract：:Acquisition of new learning is challenged by the phenomenon of proactive interference (PI), which occurs when previous learning disrupts later learning. Whereas human neuroimaging studies have focused on the cortical contributions to interference resolution, animal studies demonstrate that efficient resolution of PI d...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(04)00080-7
更新日期：2004-03-04 00:00:00
abstract：:Forty years ago, von Békésy demonstrated that the spatial source of an odorant is determined by comparing input across nostrils, but it is unknown how this comparison is effected in the brain. To address this, we delivered odorants to the left or right of the nose, and contrasted olfactory left versus right localizati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.06.028
更新日期：2005-08-18 00:00:00
abstract：:The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP, with intrinsic RNA binding activity. We have developed an approach, antibody-positioned RNA amplification (APRA), to identify the RNA cargoes associated with the in vivo configured FMRP messenger ribonucleoprotein (mRNP) complex. U...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(03)00034-5
更新日期：2003-02-06 00:00:00
abstract：:The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is involved in many cellular processes, including cell growth and differentiation, immune functions and cancer. It is activated by various cytokines, growth factors, and protein tyrosine kinases (PTKs) and regulates the transcriptio...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.11.024
更新日期：2012-01-26 00:00:00
abstract：:Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to neural system failure, however, are unknown. Using transgenic mouse models of AD together with multiphoton imaging, we measured neuronal calcium in individual neu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.06.008
更新日期：2008-07-31 00:00:00
abstract：:A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.02.017
更新日期：2011-02-24 00:00:00
abstract：:The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2005.05.001
更新日期：2005-05-19 00:00:00
abstract：:Successful visual navigation requires a sense of the geometry of the local environment. How do our brains extract this information from retinal images? Here we visually presented scenes with all possible combinations of five scene-bounding elements (left, right, and back walls; ceiling; floor) to human subjects during...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.04.014
更新日期：2019-07-03 00:00:00
abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.08.020
更新日期：2007-11-08 00:00:00
abstract：:Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.09.019
更新日期：2020-12-23 00:00:00
