Abstract：
:Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron subpopulations in slices after injection of "Retrobeads" into single target areas of adult mice and found differences in basal synaptic properties. Administration of cocaine selectively modified excitatory synapses on DA cells projecting to nucleus accumbens (NAc) medial shell while an aversive stimulus selectively modified synapses on DA cells projecting to medial prefrontal cortex. In contrast, synapses on DA neurons projecting to NAc lateral shell were modified by both rewarding and aversive stimuli, which presumably reflects saliency. These results suggest that the mesocorticolimbic DA system may be comprised of three anatomically distinct circuits, each modified by distinct aspects of motivationally relevant stimuli.
journal_name
Neuronjournal_title
Neuronauthors
Lammel S,Ion DI,Roeper J,Malenka RCdoi
10.1016/j.neuron.2011.03.025subject
Has Abstractpub_date
2011-06-09 00:00:00pages
855-62issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(11)00305-9journal_volume
70pub_type
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