Abstract:
:During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembrane protein Linx is robustly expressed in the prethalamus and lateral ganglionic eminence-derived corridor and on corticofugal axons, but not on thalamocortical axons, and that mice with a null mutation of Linx exhibit a complete absence of the IC. Moreover, regional inactivation of Linx either in the prethalamus and LGE or in the neocortex leads to a failure of IC formation. Furthermore, Linx binds to thalamocortical projections, and it promotes outgrowth of thalamic axons. Thus, Linx guides the extension of thalamocortical axons in the ventral forebrain, and subsequently, it mediates reciprocal interactions between thalamocortical and corticofugal axons to form the IC.
journal_name
Neuronjournal_title
Neuronauthors
Mandai K,Reimert DV,Ginty DDdoi
10.1016/j.neuron.2014.05.020subject
Has Abstractpub_date
2014-07-02 00:00:00pages
93-103issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(14)00406-1journal_volume
83pub_type
杂志文章相关文献
NEURON文献大全abstract::Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2010.01.016
更新日期:2010-02-25 00:00:00
abstract::Nervous system injury and disease have broad effects on the functional connectivity of the nervous system, but how injury signals are spread across neural circuits remains unclear. We explored how axotomy changes the physiology of severed axons and adjacent uninjured "bystander" neurons in a simple in vivo nerve prepa...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.11.012
更新日期:2020-12-02 00:00:00
abstract::Fluorescence imaging has enabled us to decipher spatiotemporal information coded in complex tissues. Genetically encoded probes that enable fluorescence imaging of excitable cell activity have been constructed by fusing fluorescent proteins to functional proteins that are involved in physiological signaling. The probe...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.10.003
更新日期:2005-10-20 00:00:00
abstract::Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.003
更新日期:2006-09-21 00:00:00
abstract::The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.03.010
更新日期:2017-04-05 00:00:00
abstract::Nociceptive terminals possess the elements for detecting, transmitting, and modulating noxious signals, thus being pivotal for pain sensation. Despite this, a functional description of the transduction process by the terminals, in physiological conditions, has not been fully achieved. Here, we studied how nociceptive ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.03.005
更新日期:2019-05-22 00:00:00
abstract::Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90111-p
更新日期:1992-01-01 00:00:00
abstract::The bendless (ben) mutation of Drosophila alters synaptic connectivity between a subset of CNS neurons. Here, we show that ben also causes morphological abnormalities within the visual system, suggesting that ben functions in a number of different developmental processes. We show that the ben gene encodes a protein wh...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90182-q
更新日期:1993-08-01 00:00:00
abstract::Excessive grooming behaviors, cleansing rituals, and self-mutilation are important features of a range of neuropsychiatric diseases including obsessive compulsive (OC)-spectrum disorders. In this issue of Neuron, Greer and Capecchi (2002) report that Hoxb8 mutant mice exhibit this behavioral phenotype. These Hoxb8 mut...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00575-x
更新日期:2002-01-03 00:00:00
abstract:VIDEO ABSTRACT:The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.009
更新日期:2012-03-22 00:00:00
abstract::Neurotransmitter receptors are central to communication at synapses. Many components of the machinery for neurotransmission are present prior to synapse formation, suggesting a developmental role. Here, evidence is presented that signaling through glycine receptor alpha2 (GlyRalpha2) and GABA(A) receptors plays a role...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(04)00141-2
更新日期:2004-03-25 00:00:00
abstract::Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.08.014
更新日期:2014-08-20 00:00:00
abstract::Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.030
更新日期:2010-04-29 00:00:00
abstract::The biologically active photoproduct of rhodopsin, metarhodopsin II (M II), exists in a pH-sensitive equilibrium with its precursor, metarhodopsin I (M I). Increasing acidity favors M II, with the midpoint of the pH titration curve at pH 6.4. To test the long-standing proposal that histidine protonation regulates this...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90274-h
更新日期:1992-03-01 00:00:00
abstract::The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.06.017
更新日期:2007-07-05 00:00:00
abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.003
更新日期:2019-10-23 00:00:00
abstract::Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90236-s
更新日期:1991-06-01 00:00:00
abstract::Microglia are the immune cells of the brain. Here we show a massive infiltration of highly ramified and elongated microglia within the core of amyloid plaques in transgenic mouse models of Alzheimer's disease (AD). Many of these cells originate from the bone marrow, and the beta-amyloid-40 and -42 isoforms are able to...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.01.022
更新日期:2006-02-16 00:00:00
abstract::According to economic theories, preference for one item over others reveals its rank value on a common scale. Previous studies identified brain regions encoding such values. Here we verify that these regions can valuate various categories of objects and further test whether they still express preferences when attentio...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.09.040
更新日期:2009-11-12 00:00:00
abstract::Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presyna...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00640-2
更新日期:2002-03-28 00:00:00
abstract::Although prefrontal cortex has been implicated in the cognitive regulation of emotion, the cortical-subcortical interactions that mediate this ability remain poorly understood. To address this issue, we identified a right ventrolateral prefrontal region (vlPFC) whose activity correlated with reduced negative emotional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.09.006
更新日期:2008-09-25 00:00:00
abstract::K+ channels contain two main functional domains, an ion-selective pore and a sensor that determines whether the cytoplasmic pore gate is open or closed. In this issue of Neuron, Niu et al. provide compelling evidence that the link between sensor and gate is a remarkably simple mechanical spring. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2004.05.017
更新日期:2004-06-10 00:00:00
abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.008
更新日期:2005-07-21 00:00:00
abstract::GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81044-2
更新日期:1999-12-01 00:00:00
abstract::Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.029
更新日期:2012-11-08 00:00:00
abstract::Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(92)90169-e
更新日期:1992-08-01 00:00:00
abstract::Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00268-9
更新日期:2001-04-01 00:00:00
abstract::Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2005.04.018
更新日期:2005-05-05 00:00:00
abstract::We constructed a recombinant baculovirus, A. californica nuclear polyhedrosis virus, containing the Drosophila Shaker H4 K+ channel cDNA under control of the polyhedrin promoter. When infected with this recombinant baculovirus, the cell line Sf9, derived from the army-worm caterpillar S. frugiperda, expresses fully fu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90311-3
更新日期:1990-08-01 00:00:00
abstract::Recent evidence has challenged the view that memories are made permanent by a consolidation process that happens just once and instead have suggested that memories are "re-consolidated" after reminders. The current findings of Morris et al. in this issue of Neuron suggest that reconsolidation may involve a complex int...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2006.04.017
更新日期:2006-05-04 00:00:00