Abstract:
:Circadian pacemaker neurons contain a molecular clock that oscillates with a period of approximately 24 hr, controlling circadian rhythms of behavior. Pacemaker neurons respond to visual system inputs for clock resetting, but, unlike other neurons, have not been reported to transmit rapid signals to their targets. Here we show that pacemaker neurons are required to mediate a rapid behavior. The Drosophila larval visual system, Bolwig's organ (BO), projects to larval pacemaker neurons to entrain their clock. BO also mediates larval photophobic behavior. We found that ablation or electrical silencing of larval pacemaker neurons abolished light avoidance. Thus, circadian pacemaker neurons receive input from BO not only to reset the clock but also to transmit rapid photophobic signals. Furthermore, as clock gene mutations also affect photophobicity, the pacemaker neurons modulate the sensitivity of larvae to light, generating a circadian rhythm in visual sensitivity.
journal_name
Neuronjournal_title
Neuronauthors
Mazzoni EO,Desplan C,Blau Jdoi
10.1016/j.neuron.2004.12.038subject
Has Abstractpub_date
2005-01-20 00:00:00pages
293-300issue
2eissn
0896-6273issn
1097-4199pii
S0896627304008438journal_volume
45pub_type
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