Immortalized retinal neurons derived from SV40 T-antigen-induced tumors in transgenic mice.

abstract：:Presynaptic CaV2 channels are essential for Ca2+-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca2+ channels or Ca2+ entry may control synapse assembly. Second, active zone proteins may scaffold CaV2s to presynaptic release sites, and synapse structure i...

journal_title：Neuron

authors： Held RG,Liu C,Ma K,Ramsey AM,Tarr TB,De Nola G,Wang SSH,Wang J,van den Maagdenberg AMJM,Schneider T,Sun J,Blanpied TA,Kaeser PS

更新日期：2020-08-19 00:00:00

abstract：:Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establis...

journal_title：Neuron

authors： Pool AH,Kvello P,Mann K,Cheung SK,Gordon MD,Wang L,Scott K

更新日期：2014-07-02 00:00:00

abstract：:In this issue of Neuron, Kupferschmidt et al. (2017) reveal the shifting dynamics of functionally defined corticostriatal pathways during skill learning in mice using fiber photometry. They show different time courses in plasticity of associative and sensorimotor circuits across learning that involve changes at both t...

journal_title：Neuron

authors： Corbit VL,Ahmari SE,Gittis AH

更新日期：2017-10-11 00:00:00

abstract：:The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studies attempting to elucidate the underlying mechanism for this increased risk, how apoE4 influences AD onset and progression has yet to be proven. However, prevailing evide...

journal_title：Neuron

authors： Kim J,Basak JM,Holtzman DM

更新日期：2009-08-13 00:00:00

abstract：:Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified ...

journal_title：Neuron

authors： Takatoh J,Nelson A,Zhou X,Bolton MM,Ehlers MD,Arenkiel BR,Mooney R,Wang F

更新日期：2013-01-23 00:00:00

abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...

journal_title：Neuron

authors： Sharma N,Deppmann CD,Harrington AW,St Hillaire C,Chen ZY,Lee FS,Ginty DD

更新日期：2010-08-12 00:00:00

abstract：:The Drosophila Dscams are immunoglobulin superfamily members produced from a single gene that is diversified by alternative splicing to produce a family of cell-surface proteins with over 19,000 different ectodomain isoforms. Dscams are critical for neuronal wiring, and mounting evidence suggests that they play a key ...

journal_title：Neuron

authors： Shapiro L

更新日期：2007-10-04 00:00:00

abstract：:The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation a...

journal_title：Neuron

authors： Song J,Zipser B

更新日期：1995-03-01 00:00:00

abstract：:Spontaneous and sensory-evoked cortical activity is highly state-dependent, yet relatively little is known about transitions between distinct waking states. Patterns of activity in mouse V1 differ dramatically between quiescence and locomotion, but this difference could be explained by either motor feedback or a chang...

journal_title：Neuron

authors： Vinck M,Batista-Brito R,Knoblich U,Cardin JA

更新日期：2015-05-06 00:00:00

abstract：:Experience is a powerful sculptor of developing neural connections. In the primary visual cortex (V1), cortical connections are particularly susceptible to the effects of sensory manipulation during a postnatal critical period. At the molecular level, this activity-dependent plasticity requires the transformation of s...

journal_title：Neuron

authors： Taha S,Hanover JL,Silva AJ,Stryker MP

更新日期：2002-10-24 00:00:00

abstract：:Effective mental functioning requires that cognition be protected from emotional conflict due to interference by task-irrelevant emotionally salient stimuli. The neural mechanisms by which the brain detects and resolves emotional conflict are still largely unknown, however. Drawing on the classic Stroop conflict task,...

journal_title：Neuron

authors： Etkin A,Egner T,Peraza DM,Kandel ER,Hirsch J

更新日期：2006-09-21 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Here, we show that reductions in CaMKII activity trigger persistent increases in intrinsic excitability. In spontaneously firing ves...

journal_title：Neuron

authors： Nelson AB,Gittis AH,du Lac S

更新日期：2005-05-19 00:00:00

abstract：:Olfactory receptor neurons (ORNs) are replaced and differentiate in adult animals, but differentiation in dissociated cell culture has not been demonstrated. To test whether contact with the CNS regulates maturation, neonatal rat olfactory cells were grown on a culture substrate or on CNS astrocytes. Mature ORNs, immu...

journal_title：Neuron

authors： Pixley SK

更新日期：1992-06-01 00:00:00

abstract：:Although many studies have identified neural correlates of memory, relatively little is known about the circuit properties connecting single-neuron physiology to behavior. Here we developed a modeling framework to bridge this gap and identify circuit interactions capable of maintaining short-term memory. Unlike typica...

journal_title：Neuron

authors： Fisher D,Olasagasti I,Tank DW,Aksay ER,Goldman MS

更新日期：2013-09-04 00:00:00

abstract：:The level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent timing. Cx36-deficient mice showed impaired timing of both locomotion and eye-...

journal_title：Neuron

authors： Van Der Giessen RS,Koekkoek SK,van Dorp S,De Gruijl JR,Cupido A,Khosrovani S,Dortland B,Wellershaus K,Degen J,Deuchars J,Fuchs EC,Monyer H,Willecke K,De Jeu MT,De Zeeuw CI

更新日期：2008-05-22 00:00:00

abstract：:The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, im...

journal_title：Neuron

authors： Rebola N,Reva M,Kirizs T,Szoboszlay M,Lőrincz A,Moneron G,Nusser Z,DiGregorio DA

更新日期：2019-11-20 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus and indirectly from the auditory cortex. Here we show in the cortico-amygdala pathway that learned fear occludes electricall...

journal_title：Neuron

authors： Tsvetkov E,Carlezon WA,Benes FM,Kandel ER,Bolshakov VY

更新日期：2002-04-11 00:00:00

abstract：:Two rabbit polyclonal antibodies generated against different portions of the amyloid precursor protein were used to localize this protein in normal rat brain. Light and electron microscopic immunohistochemical localizations demonstrate that the protein is widely distributed throughout the neuraxis, with the highest co...

journal_title：Neuron

authors： Card JP,Meade RP,Davis LG

更新日期：1988-11-01 00:00:00

abstract：:The ability of the brain to store and process information relies on changing the strength of connections between neurons. Synaptic facilitation is a form of short-term plasticity that enhances synaptic transmission for less than a second. Facilitation is a ubiquitous phenomenon thought to play critical roles in inform...

journal_title：Neuron

authors： Jackman SL,Regehr WG

更新日期：2017-05-03 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:N-type calcium channels are critical for pain transduction. Inhibitors of these channels are powerful analgesics, but clinical use of current N-type blockers remains limited by undesirable actions in other regions of the nervous system. We now demonstrate that a unique splice isoform of the N-type channel is restricte...

journal_title：Neuron

authors： Bell TJ,Thaler C,Castiglioni AJ,Helton TD,Lipscombe D

更新日期：2004-01-08 00:00:00

abstract：:Excitotoxic cell death stimulated by quinolinic acid injection into the striatum has a long history of "mimicking" many aspects of motor, behavioral, and neurochemical changes observed in Huntington's disease patients. In this issue of Neuron, provide insight into the role of NMDA receptors in the cell-specific excito...

journal_title：Neuron

authors： Ellerby LM

更新日期：2002-03-14 00:00:00

abstract：:In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...

journal_title：Neuron

authors： Pitkow X

更新日期：2016-10-19 00:00:00

abstract：:The decision to engage in one behavior often precludes the selection of others, suggesting cross-inhibition between incompatible behaviors. For example, the likelihood to initiate feeding might be influenced by an animal's commitment to other behaviors. Here, we examine the modulation of feeding behavior in the fruit ...

journal_title：Neuron

authors： Mann K,Gordon MD,Scott K

更新日期：2013-08-21 00:00:00

abstract：:Although pain is defined as a sensory and emotional experience, it is traditionally researched and clinically treated separately from emotion. Conceptual and mechanistic relationships between these constructs highlight the need for better understanding of their bi-directional influences and the value of bridging the p...

journal_title：Neuron

authors： Gilam G,Gross JJ,Wager TD,Keefe FJ,Mackey SC

更新日期：2020-07-08 00:00:00

abstract：:Cued spatial attention differentially modulates alpha power in attended relative to non-attended brain representations, termed the alpha asymmetry. Yet a causal role for alpha in attention is debated. In this issue of Neuron, Bagherzadeh et al., (2019) utilize neurofeedback to train alpha asymmetry and causally impact...

journal_title：Neuron

authors： Jones SR,Sliva DD

更新日期：2020-02-05 00:00:00

abstract：:Elucidating the molecular mechanisms underlying quantitative neurocognitive phenotypes will further our understanding of the brain's structural and functional architecture and advance the diagnosis and treatment of the psychiatric disorders that these traits underlie. Although many neurocognitive traits are highly her...

journal_title：Neuron

authors： Congdon E,Poldrack RA,Freimer NB

更新日期：2010-10-21 00:00:00

abstract：:mRNA coding for brain-derived neurotrophic factor (BDNF) has been detected in cultured L929 fibroblasts, rat dermal fibroblasts, and sciatic nerve Schwann cells, as well as in rat skin. Medium conditioned by cultured fibroblasts and Schwann cells also stimulates neurite growth from retinal explants and promotes the su...

journal_title：Neuron

authors： Acheson A,Barker PA,Alderson RF,Miller FD,Murphy RA

更新日期：1991-08-01 00:00:00

abstract：:We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...

journal_title：Neuron

authors： Maconochie DJ,Zempel JM,Steinbach JH

更新日期：1994-01-01 00:00:00