Cognitive association formation in human memory revealed by spatiotemporal brain imaging.

Abstract:

:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding processes were isolated by subtracting fusion task ERPs corresponding to pairs later retrieved quickly from ERPs corresponding to pairs later retrieved slowly, separately for pairs fused successfully and unsuccessfully (i.e., juxtaposed). Analyses revealed that the encoding of these two types of associations yields different ERP voltage polarities, scalp topographies, and brain sources extending over the entire time course of processing.

journal_name

Neuron

journal_title

Neuron

authors

Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

doi

10.1016/s0896-6273(01)00199-4

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

297-306

issue

1

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(01)00199-4

journal_volume

29

pub_type

临床试验,杂志文章

相关文献

NEURON文献大全
  • RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.

    abstract::Fragile X-associated tremor/ataxia syndrome (FXTAS) is a recently described neurodegenerative disorder of older adult carriers of premutation alleles (60-200 CGG repeats) in the fragile X mental retardation gene (FMR1). It has been proposed that FXTAS is an RNA-mediated neurodegenerative disease caused by the titratio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.07.021

    authors: Sofola OA,Jin P,Qin Y,Duan R,Liu H,de Haro M,Nelson DL,Botas J

    更新日期:2007-08-16 00:00:00

  • Presynaptic regulation of neurotransmission in Drosophila by the g protein-coupled receptor methuselah.

    abstract::Regulation of synaptic strength is essential for neuronal information processing, but the molecular mechanisms that control changes in neuroexocytosis are only partially known. Here we show that the putative G protein-coupled receptor Methuselah (Mth) is required in the presynaptic motor neuron to acutely upregulate n...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(02)00932-7

    authors: Song W,Ranjan R,Dawson-Scully K,Bronk P,Marin L,Seroude L,Lin YJ,Nie Z,Atwood HL,Benzer S,Zinsmaier KE

    更新日期:2002-09-26 00:00:00

  • Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.

    abstract::In neurons, posttranslational modification by palmitate regulates the trafficking and function of signaling molecules, neurotransmitter receptors, and associated synaptic scaffolding proteins. However, the enzymatic machinery involved in protein palmitoylation has remained elusive. Here, using biochemical assays, we s...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.11.027

    authors: Huang K,Yanai A,Kang R,Arstikaitis P,Singaraja RR,Metzler M,Mullard A,Haigh B,Gauthier-Campbell C,Gutekunst CA,Hayden MR,El-Husseini A

    更新日期:2004-12-16 00:00:00

  • The GABAB1b isoform mediates long-lasting inhibition of dendritic Ca2+ spikes in layer 5 somatosensory pyramidal neurons.

    abstract::The apical tuft of layer 5 pyramidal neurons is innervated by a large number of inhibitory inputs with unknown functions. Here, we studied the functional consequences and underlying molecular mechanisms of apical inhibition on dendritic spike activity. Extracellular stimulation of layer 1, during blockade of glutamate...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.04.019

    authors: Pérez-Garci E,Gassmann M,Bettler B,Larkum ME

    更新日期:2006-05-18 00:00:00

  • Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

    abstract::Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter mi...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2009.03.026

    authors: Renthal W,Kumar A,Xiao G,Wilkinson M,Covington HE 3rd,Maze I,Sikder D,Robison AJ,LaPlant Q,Dietz DM,Russo SJ,Vialou V,Chakravarty S,Kodadek TJ,Stack A,Kabbaj M,Nestler EJ

    更新日期:2009-05-14 00:00:00

  • Heterosynaptic Plasticity Underlies Aversive Olfactory Learning in Drosophila.

    abstract::Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activati...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2015.11.003

    authors: Hige T,Aso Y,Modi MN,Rubin GM,Turner GC

    更新日期:2015-12-02 00:00:00

  • Cxcr7 controls neuronal migration by regulating chemokine responsiveness.

    abstract::The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated. Here, we used the migration of...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.12.006

    authors: Sánchez-Alcañiz JA,Haege S,Mueller W,Pla R,Mackay F,Schulz S,López-Bendito G,Stumm R,Marín O

    更新日期:2011-01-13 00:00:00

  • Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

    abstract::Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2012.04.038

    authors: Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

    更新日期:2012-07-12 00:00:00

  • The molecular and cellular identity of peripheral osmoreceptors.

    abstract::In mammals, the osmolality of the extracellular fluid (ECF) is highly stable despite radical changes in salt/water intake and excretion. Afferent systems are required to detect hypo- or hyperosmotic shifts in the ECF to trigger homeostatic control of osmolality. In humans, a pressor reflex is triggered by simply drink...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.12.028

    authors: Lechner SG,Markworth S,Poole K,Smith ES,Lapatsina L,Frahm S,May M,Pischke S,Suzuki M,Ibañez-Tallon I,Luft FC,Jordan J,Lewin GR

    更新日期:2011-01-27 00:00:00

  • Kinesin transports RNA: isolation and characterization of an RNA-transporting granule.

    abstract::RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2004.07.022

    authors: Kanai Y,Dohmae N,Hirokawa N

    更新日期:2004-08-19 00:00:00

  • NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein.

    abstract::Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)00147-1

    authors: Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

    更新日期:2000-12-01 00:00:00

  • Enigmas of the dentate gyrus.

    abstract::We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.07.002

    authors: Leutgeb JK,Moser EI

    更新日期:2007-07-19 00:00:00

  • Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory.

    abstract::Cortical plasticity is thought to be important for the establishment, consolidation, and retrieval of permanent memory. Hippocampal long-term potentiation (LTP), a cellular mechanism of learning and memory, requires the activation of glutamate N-methyl-D-aspartate (NMDA) receptors. In particular, it has been suggested...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.08.014

    authors: Zhao MG,Toyoda H,Lee YS,Wu LJ,Ko SW,Zhang XH,Jia Y,Shum F,Xu H,Li BM,Kaang BK,Zhuo M

    更新日期:2005-09-15 00:00:00

  • CUL3 Deficiency Causes Social Deficits and Anxiety-like Behaviors by Impairing Excitation-Inhibition Balance through the Promotion of Cap-Dependent Translation.

    abstract::Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with symptoms including social deficits, anxiety, and communication difficulties. However, ASD pathogenic mechanisms are poorly understood. Mutations of CUL3, which encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of a...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2019.10.035

    authors: Dong Z,Chen W,Chen C,Wang H,Cui W,Tan Z,Robinson H,Gao N,Luo B,Zhang L,Zhao K,Xiong WC,Mei L

    更新日期:2020-02-05 00:00:00

  • Signatures of a Statistical Computation in the Human Sense of Confidence.

    abstract::Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.03.025

    authors: Sanders JI,Hangya B,Kepecs A

    更新日期:2016-05-04 00:00:00

  • Probability by Time.

    abstract::In this issue of Neuron, Orbán et al. (2016) test whether the brain represents probabilities by sampling: do neurons interpret the world by generating causal explanations of sense data and quickly sample different interpretations over time? Orbán et al. (2016) find agreement between this model's predictions and neural...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2016.10.007

    authors: Pitkow X

    更新日期:2016-10-19 00:00:00

  • Hidden Figures: A Non-translated RNA Regulates Axonal Neurotrophin Signaling.

    abstract::In this issue of Neuron, Crerar et al. (2019) found Tp53inp2 as a highly expressed RNA in sympathetic neuron axons. Strikingly, its long 3' UTR ensures that Tp53inp2 is not translated in axons, and the untranslated RNA affects neuronal growth by interacting with neurotrophin receptors. ...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2019.04.019

    authors: Panayotis N,Fainzilber M

    更新日期:2019-05-08 00:00:00

  • Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif.

    abstract::Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique me...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2006.11.023

    authors: Takahashi H,Shin Y,Cho SJ,Zago WM,Nakamura T,Gu Z,Ma Y,Furukawa H,Liddington R,Zhang D,Tong G,Chen HS,Lipton SA

    更新日期:2007-01-04 00:00:00

  • Anterior regions of monkey parietal cortex process visual 3D shape.

    abstract::The intraparietal cortex is involved in the control of visually guided actions, like reach-to-grasp movements, which require extracting the 3D shape and position of objects from 2D retinal images. Using fMRI in behaving monkeys, we investigated the role of the intraparietal cortex in processing stereoscopic informatio...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2007.06.040

    authors: Durand JB,Nelissen K,Joly O,Wardak C,Todd JT,Norman JF,Janssen P,Vanduffel W,Orban GA

    更新日期:2007-08-02 00:00:00

  • Dynamic Nigrostriatal Dopamine Biases Action Selection.

    abstract::Dopamine is thought to play a critical role in reinforcement learning and goal-directed behavior, but its function in action selection remains largely unknown. Here we demonstrate that nigrostriatal dopamine biases ongoing action selection. When mice were trained to dynamically switch the action selected at different ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2017.02.029

    authors: Howard CD,Li H,Geddes CE,Jin X

    更新日期:2017-03-22 00:00:00

  • Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.

    abstract::The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2010.11.030

    authors: Hoover BR,Reed MN,Su J,Penrod RD,Kotilinek LA,Grant MK,Pitstick R,Carlson GA,Lanier LM,Yuan LL,Ashe KH,Liao D

    更新日期:2010-12-22 00:00:00

  • An inside look at hippocampal silent cells.

    abstract::Hippocampal pyramidal cells can be divided into place cells, which fire action potentials when an animal is in specific locations, and silent cells, which are not spatially selective. In this issue of Neuron, Epsztein et al. find intracellular differences between place and silent cells by using whole-cell recordings i...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2011.03.015

    authors: Ferguson JE,Jackson JC,Redish AD

    更新日期:2011-04-14 00:00:00

  • Facilitation of NMDAR-independent LTP and spatial learning in mutant mice lacking ryanodine receptor type 3.

    abstract::To evaluate the role in synaptic plasticity of ryanodine receptor type 3 (RyR3), which is normally enriched in hippocampal area CA1, we generated RyR3-deficient mice. Mutant mice exhibited facilitated CA1 long-term potentiation (LTP) induced by short tetanus (100 Hz, 100 ms) stimulation. Unlike LTP in wild-type mice, ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)81123-x

    authors: Futatsugi A,Kato K,Ogura H,Li ST,Nagata E,Kuwajima G,Tanaka K,Itohara S,Mikoshiba K

    更新日期:1999-11-01 00:00:00

  • Hooked on the D3 receptor: CaMKII's new addiction.

    abstract::The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavi...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2009.01.025

    authors: Hell JW

    更新日期:2009-02-12 00:00:00

  • A spoonful of bitter helps the sugar response go down.

    abstract::Sweet and bitter taste distinguishes good food sources from potential toxins, but what happens when these tastants are mixed? In this issue of Neuron, Jeong et al. (2013) show that in Drosophila, bitter compounds act through an extracellular odorant-binding protein to inhibit sweet-responsive neurons and block the res...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2013.07.038

    authors: Lvovskaya S,Smith DP

    更新日期:2013-08-21 00:00:00

  • Building neural choice points for love and war.

    abstract::The molecular specification of central circuits that coordinate expression of innate behaviors in response to specific sensory cues from the environment remains a puzzle. In this issue of Neuron, Choi, Dong, and colleagues used expression profiling and genetic axonal tracing to visualize a hypothalamic point of conver...

    journal_title:Neuron

    pub_type: 评论,杂志文章

    doi:10.1016/j.neuron.2005.05.001

    authors: Simerly R

    更新日期:2005-05-19 00:00:00

  • FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor.

    abstract::We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(00)00119-7

    authors: Taupin P,Ray J,Fischer WH,Suhr ST,Hakansson K,Grubb A,Gage FH

    更新日期:2000-11-01 00:00:00

  • How far will you go to sense voltage?

    abstract::Despite tremendous progress in the study of voltage-gated channels, the molecular mechanism underlying voltage sensing has remained a matter of debate. We review five new studies that make major progress in the field. The studies employ a battery of distinct approaches that have the common aim of measuring the motion ...

    journal_title:Neuron

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuron.2005.11.024

    authors: Tombola F,Pathak MM,Isacoff EY

    更新日期:2005-12-08 00:00:00

  • A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement.

    abstract::The directional selectivity of retinal ganglion cell responses represents a primitive pattern recognition that operates within a retinal neural circuit. The cellular origin and mechanism of directional selectivity were investigated by selectively eliminating retinal starburst amacrine cells, using immunotoxin-mediated...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/s0896-6273(01)00316-6

    authors: Yoshida K,Watanabe D,Ishikane H,Tachibana M,Pastan I,Nakanishi S

    更新日期:2001-06-01 00:00:00

  • Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding.

    abstract::Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form t...

    journal_title:Neuron

    pub_type: 杂志文章

    doi:10.1016/j.neuron.2005.12.026

    authors: Franks KM,Isaacson JS

    更新日期:2006-02-02 00:00:00