Abstract：
:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity in dopamine neurons. We paired electrophysiological recordings of striatal channelrhodopsin2-expressing cholinergic interneurons with simultaneous detection of dopamine release at carbon-fiber microelectrodes in striatal slices. We reveal that activation of cholinergic interneurons by light flashes that cause only single action potentials in neurons from a small population triggers dopamine release via activation of nicotinic receptors on dopamine axons. This event overrides ascending activity from dopamine neurons and, furthermore, is reproduced by activating ChR2-expressing thalamostriatal inputs, which synchronize cholinergic interneurons in vivo. These findings indicate that synchronized activity in cholinergic interneurons directly generates striatal dopamine signals whose functions will extend beyond those encoded by dopamine neuron activity.
journal_name
Neuronjournal_title
Neuronauthors
Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJdoi
10.1016/j.neuron.2012.04.038subject
Has Abstractpub_date
2012-07-12 00:00:00pages
58-64issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(12)00443-6journal_volume
75pub_type
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