Abstract:
:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narcolepsy remains unknown. Here we show that human narcoleptics have an 85%-95% reduction in the number of Hcrt neurons. Melanin-concentrating hormone (MCH) neurons, which are intermixed with Hcrt cells in the normal brain, are not reduced in number, indicating that cell loss is relatively specific for Hcrt neurons. The presence of gliosis in the hypocretin cell region is consistent with a degenerative process being the cause of the Hcrt cell loss in narcolepsy.
journal_name
Neuronjournal_title
Neuronauthors
Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JMdoi
10.1016/s0896-6273(00)00058-1subject
Has Abstractpub_date
2000-09-01 00:00:00pages
469-74issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(00)00058-1journal_volume
27pub_type
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