Abstract:
:Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assays, we identify principles of afferent-specific control in the mesolimbic DA system. Neurons in the medial shell subdivision of the nucleus accumbens (NAc) exert direct inhibitory control over two separate populations of mesolimbic DA neurons by activating different GABA receptor subtypes. In contrast, NAc lateral shell neurons mainly synapse onto ventral tegmental area (VTA) GABA neurons, resulting in disinhibition of DA neurons that project back to the NAc lateral shell. Lastly, we establish a critical role for NAc subregion-specific input to the VTA underlying motivated behavior. Collectively, our results suggest a distinction in the incorporation of inhibitory inputs between different subtypes of mesolimbic DA neurons.
journal_name
Neuronjournal_title
Neuronauthors
Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel Sdoi
10.1016/j.neuron.2017.12.022subject
Has Abstractpub_date
2018-01-17 00:00:00pages
434-449.e4issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(17)31169-8journal_volume
97pub_type
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