Abstract：
:During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neural circuitry, and subsequent matching of glial numbers and position to that circuitry. Here, we have reviewed work addressing the mechanisms underlying this timed cell genesis, with a particular focus on the developing cortex. These studies have defined an intriguing interplay between intrinsic epigenetic status, transcription factors, and environmental cues, all of which work together to establish this fascinating and complex biological timing mechanism.
journal_name
Neuronjournal_title
Neuronauthors
Miller FD,Gauthier ASdoi
10.1016/j.neuron.2007.04.019subject
Has Abstractpub_date
2007-05-03 00:00:00pages
357-69issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(07)00298-Xjournal_volume
54pub_type
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