Abstract：
:Hundreds of G protein-coupled receptors (GPCRs) and at least six GPCR kinases have been identified, but the only GPCR phosphatase that has been definitively demonstrated is the rhodopsin phosphatase encoded by the rdgC locus of Drosophila. Mutations in rdgC result in defects in termination of the light response and cause severe retinal degeneration. In the current work, we demonstrate that RDGC binds to calmodulin, and a mutation in an IQ motif that eliminates the calmodulin/RDGC interaction prevents dephosphorylation of rhodopsin in vivo and disrupts termination of the photoresponse. Our data indicate that RDGC is a novel calmodulin-dependent protein phosphatase and raise the possibility that regulation of other GPCRs through dephosphorylation may be controlled by calmodulin-dependent protein phosphatases related to RDGC.
journal_name
Neuronjournal_title
Neuronauthors
Lee SJ,Montell Cdoi
10.1016/s0896-6273(01)00538-4subject
Has Abstractpub_date
2001-12-20 00:00:00pages
1097-106issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(01)00538-4journal_volume
32pub_type
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