Synchronization of olfactory bulb mitral cells by precisely timed inhibitory inputs.

abstract：:Although associative learning has been localized to specific brain areas in many animals, identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the first demonstration of long-term synaptic plasticity at the output site of the Drosophila mushroom body. Pairing an odor with activati...

journal_title：Neuron

authors： Hige T,Aso Y,Modi MN,Rubin GM,Turner GC

更新日期：2015-12-02 00:00:00

abstract：:The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...

journal_title：Neuron

authors： Gonzalez-Castillo J,Bandettini PA

更新日期：2015-06-17 00:00:00

abstract：:We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. ...

journal_title：Neuron

authors： Crone SA,Negro A,Trumpp A,Giovannini M,Lee KF

更新日期：2003-01-09 00:00:00

abstract：:Neuroscience relies on techniques for imaging the structure and dynamics of neural circuits, but the cell bodies of individual neurons are often obscured by overlapping fluorescence from axons and dendrites in surrounding neuropil. Here, we describe two strategies for using the ribosome to restrict the expression of f...

journal_title：Neuron

authors： Chen Y,Jang H,Spratt PWE,Kosar S,Taylor DE,Essner RA,Bai L,Leib DE,Kuo TW,Lin YC,Patel M,Subkhangulova A,Kato S,Feinberg EH,Bender KJ,Knight ZA,Garrison JL

更新日期：2020-08-05 00:00:00

abstract：:Neuronal gain control is important for processing information in the brain. Shunting inhibition is not thought to control gain since it shifts input-output relationships during tonic excitation rather than changing their slope. Here we show that tonic inhibition reduces the gain and shifts the offset of cerebellar gra...

journal_title：Neuron

authors： Mitchell SJ,Silver RA

更新日期：2003-05-08 00:00:00

abstract：:Axon bifurcation results in the formation of sister branches, and divergent segregation of the sister branches is essential for efficient innervation of multiple targets. From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs se...

journal_title：Neuron

authors： Wang J,Zugates CT,Liang IH,Lee CH,Lee T

更新日期：2002-02-14 00:00:00

abstract：:The earliest stages of Alzheimer's disease (AD) are characterized by the formation of mature tangles in the entorhinal cortex and disorientation and confusion when navigating familiar places. The medial entorhinal cortex (MEC) contains specialized neurons called grid cells that form part of the spatial navigation syst...

journal_title：Neuron

authors： Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE

更新日期：2017-02-08 00:00:00

abstract：:Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater...

journal_title：Neuron

authors： Vernino S,Amador M,Luetje CW,Patrick J,Dani JA

更新日期：1992-01-01 00:00:00

abstract：:In this issue of Neuron, Costa et al. (2017) introduce a theoretical framework that predicts the ratio of presynaptic and postsynaptic changes taking place during LTP and LTD and show that these processes co-operate so as to optimize the postsynaptic response statistics. ...

journal_title：Neuron

authors： Poirazi P,Kastellakis G

更新日期：2017-09-27 00:00:00

abstract：:Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...

journal_title：Neuron

authors： Dyhrfjeld-Johnsen J,Soltesz I

更新日期：2004-10-28 00:00:00

abstract：:Trk tyrosine kinases are receptors for members of the neurotrophin family and are crucial for growth and survival of specific populations of neurons. Yet, the functions of neurotrophin-Trk signaling in postnatal development as well as maintenance and plasticity of the adult nervous system are less clear. We report her...

journal_title：Neuron

authors： Chen X,Ye H,Kuruvilla R,Ramanan N,Scangos KW,Zhang C,Johnson NM,England PM,Shokat KM,Ginty DD

更新日期：2005-04-07 00:00:00

abstract：:Local axon degeneration is a common pathological feature of many neurodegenerative diseases and peripheral neuropathies. While it is believed to operate with an apoptosis-independent molecular program, the underlying molecular mechanisms are largely unknown. In this study, we used the degeneration of transected axons,...

journal_title：Neuron

authors： Zhai Q,Wang J,Kim A,Liu Q,Watts R,Hoopfer E,Mitchison T,Luo L,He Z

更新日期：2003-07-17 00:00:00

abstract：:We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of the superior colliculus (SC). EphBs are expressed in a D-V gradient, ephrin-B1 in a L-M gradient in SC, and ephrin-B3 at its midline. EphBs and ephrin-Bs are ex...

journal_title：Neuron

authors： Hindges R,McLaughlin T,Genoud N,Henkemeyer M,O'Leary D

更新日期：2002-08-01 00:00:00

abstract：:Humans can easily focus on one speaker in a multi-talker acoustic environment, but how different areas of the human auditory cortex (AC) represent the acoustic components of mixed speech is unknown. We obtained invasive recordings from the primary and nonprimary AC in neurosurgical patients as they listened to multi-t...

journal_title：Neuron

authors： O'Sullivan J,Herrero J,Smith E,Schevon C,McKhann GM,Sheth SA,Mehta AD,Mesgarani N

更新日期：2019-12-18 00:00:00

abstract：:In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an ...

journal_title：Neuron

authors： Michaud JP,Rivest S

更新日期：2015-02-04 00:00:00

abstract：:Today we are witnessing a new science of placebo, a complex discipline that encompasses several experimental approaches and translational implications. Modern neurobiological tools have been used to answer important questions in placebo research, such as the top-down modulation of sensory and motor systems as well as ...

journal_title：Neuron

authors： Benedetti F

更新日期：2014-11-05 00:00:00

abstract：:Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a n...

journal_title：Neuron

authors： Luo HR,Saiardi A,Nagata E,Ye K,Yu H,Jung TS,Luo X,Jain S,Sawa A,Snyder SH

更新日期：2001-08-16 00:00:00

abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...

journal_title：Neuron

authors： Rasband K,Hardy M,Chien CB

更新日期：2003-09-11 00:00:00

abstract：:AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and...

journal_title：Neuron

authors： Mansour M,Nagarajan N,Nehring RB,Clements JD,Rosenmund C

更新日期：2001-12-06 00:00:00

abstract：:Mammalian olfactory sensory neurons that express a particular odorant receptor (OR) project axons to the same few glomeruli in the olfactory bulb. In this issue of Neuron, Vassalli et al. use OR minigenes that coexpress histochemical markers and show that the determinants in the sensory neurons required to generate th...

journal_title：Neuron

authors： Ranganathan R,Buck LB

更新日期：2002-08-15 00:00:00

abstract：:Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Here, we have developed a class of tau ligands, phenyl/pyridinyl-butadienyl-benzothiazoles/benzothiazoliums (PBBs), for visualizing diverse tau inclusions...

journal_title：Neuron

authors： Maruyama M,Shimada H,Suhara T,Shinotoh H,Ji B,Maeda J,Zhang MR,Trojanowski JQ,Lee VM,Ono M,Masamoto K,Takano H,Sahara N,Iwata N,Okamura N,Furumoto S,Kudo Y,Chang Q,Saido TC,Takashima A,Lewis J,Jang MK,Aoki I,

更新日期：2013-09-18 00:00:00

abstract：:Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...

journal_title：Neuron

authors： Tse FW,Tse A,Hille B,Horstmann H,Almers W

更新日期：1997-01-01 00:00:00

abstract：:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...

journal_title：Neuron

authors： Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

更新日期：1992-12-01 00:00:00

abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...

journal_title：Neuron

authors： Deouell LY,Heller AS,Malach R,D'Esposito M,Knight RT

更新日期：2007-09-20 00:00:00

abstract：:Incoming stimuli are encoded collectively by populations of cortical neurons, which transmit information by using a neural code thought to be predominantly redundant. Redundant coding is widely believed to reflect a design choice whereby neurons with overlapping receptive fields sample environmental stimuli to convey ...

journal_title：Neuron

authors： Nigam S,Pojoga S,Dragoi V

更新日期：2019-10-23 00:00:00

abstract：:Recent studies have shown that hippocampal "time cells" code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inacti...

journal_title：Neuron

authors： Robinson NTM,Priestley JB,Rueckemann JW,Garcia AD,Smeglin VA,Marino FA,Eichenbaum H

更新日期：2017-05-03 00:00:00

abstract：:The distribution of the synaptic vesicle-associated phosphoprotein synapsin I after electrical stimulation of the frog neuromuscular junction was investigated by immunogold labeling and compared with the distribution of the integral synaptic vesicle protein synaptophysin. In resting terminals both proteins were locali...

journal_title：Neuron

authors： Torri Tarelli F,Bossi M,Fesce R,Greengard P,Valtorta F

更新日期：1992-12-01 00:00:00

abstract：:In this issue of Neuron, Kraus et al. (2013) show that a population of "time cells" in the hippocampus responds to the passage of time rather than simply reflecting path integration. This study advances our understanding of how time is represented in the hippocampus. ...

journal_title：Neuron

authors： Rowland DC,Moser MB

更新日期：2013-06-19 00:00:00

abstract：:Proteolipid protein (PLP) is an integral membrane protein of CNS myelin. Mutations of the X chromosome-linked PLP gene cause glial cell death and myelin deficiency in jimpy mice and other neurological mutants. As part of an attempt to rescue these mutants by transgenic complementation, we generated normal mouse lines ...

journal_title：Neuron

authors： Readhead C,Schneider A,Griffiths I,Nave KA

更新日期：1994-03-01 00:00:00

abstract：:Disruption of one allele of the LIS1 gene causes a severe developmental brain abnormality, type I lissencephaly. In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth. Recently, we demonstrated that mammalian LIS1 regulates dy...

journal_title：Neuron

authors： Niethammer M,Smith DS,Ayala R,Peng J,Ko J,Lee MS,Morabito M,Tsai LH

更新日期：2000-12-01 00:00:00