Abstract:
:Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr time period, they are triggered by 15 min of seizure. Alterations in the levels and composition of transcription factors may represent one of the molecular mechanisms underlying neuronal adaptation.
journal_name
Neuronjournal_title
Neuronauthors
Sonnenberg JL,Macgregor-Leon PF,Curran T,Morgan JIdoi
10.1016/0896-6273(89)90260-2subject
Has Abstractpub_date
1989-09-01 00:00:00pages
359-65issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(89)90260-2journal_volume
3pub_type
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