Abstract:
:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courting target. By reducing the number of neurons expressing dTrpA1 by MARCM, we demonstrated that the initiation of courtship behavior is significantly correlated with the activation of the transmidline P1 interneurons, the descending P2b interneurons, or both, indicating that these interneurons trigger courtship. Using an experimental paradigm in which a tethered male can be stimulated to initiate courtship by touching his foreleg tarsus to a female's abdomen, we found that P1 neurites of tethered males showed a transient Ca(2+) rise after tarsal stimulation with the female-associated sensory cues. These observations strongly suggest that P1 neurons are the prime components of the neural circuitry that initiates male courtship.
journal_name
Neuronjournal_title
Neuronauthors
Kohatsu S,Koganezawa M,Yamamoto Ddoi
10.1016/j.neuron.2010.12.017subject
Has Abstractpub_date
2011-02-10 00:00:00pages
498-508issue
3eissn
0896-6273issn
1097-4199pii
S0896-6273(10)01040-8journal_volume
69pub_type
杂志文章相关文献
NEURON文献大全abstract::In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(01)00370-1
更新日期:2001-08-02 00:00:00
abstract::Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2014.08.014
更新日期:2014-08-20 00:00:00
abstract::To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of hori...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.02.023
更新日期:2018-04-04 00:00:00
abstract::There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.06.041
更新日期:2015-07-15 00:00:00
abstract::Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.09.050
更新日期:2015-11-18 00:00:00
abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2016.07.031
更新日期:2016-08-03 00:00:00
abstract::In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for comple...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.08.004
更新日期:2012-08-23 00:00:00
abstract::Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.12.006
更新日期:2010-01-14 00:00:00
abstract::Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.06.013
更新日期:2011-08-11 00:00:00
abstract::Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding ta...
journal_title:Neuron
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuron.2014.08.047
更新日期:2014-10-01 00:00:00
abstract::Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.09.001
更新日期:2007-09-20 00:00:00
abstract::Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.10.001
更新日期:2011-10-20 00:00:00
abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.029
更新日期:2006-11-22 00:00:00
abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90272-s
更新日期:1993-07-01 00:00:00
abstract::Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propag...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.08.039
更新日期:2012-11-21 00:00:00
abstract::We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00144-2
更新日期:2003-03-27 00:00:00
abstract::I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00570-1
更新日期:2003-09-25 00:00:00
abstract::Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2008.08.001
更新日期:2008-08-14 00:00:00
abstract::Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80344-x
更新日期:1997-07-01 00:00:00
abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00466-4
更新日期:2001-10-25 00:00:00
abstract::Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.07.004
更新日期:2008-08-28 00:00:00
abstract::We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.10.006
更新日期:2009-11-12 00:00:00
abstract::During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80705-9
更新日期:1999-03-01 00:00:00
abstract::We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90297-d
更新日期:1991-09-01 00:00:00
abstract::Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.042
更新日期:2019-11-20 00:00:00
abstract::Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.11.038
更新日期:2006-01-19 00:00:00
abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00682-2
更新日期:2003-10-30 00:00:00
abstract::The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2012.06.002
更新日期:2012-06-21 00:00:00
abstract::Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.04.007
更新日期:2010-05-13 00:00:00
abstract::Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2018.02.018
更新日期:2018-03-07 00:00:00