Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.

abstract：:Since the early days of research into language and the brain, word meaning was assumed to be processed in specific brain regions, which most modern neuroscientists localize to the left temporal lobe. Here we use event-related fMRI to show that action words referring to face, arm, or leg actions (e.g., to lick, pick, o...

journal_title：Neuron

authors： Hauk O,Johnsrude I,Pulvermüller F

更新日期：2004-01-22 00:00:00

abstract：:During development of the peripheral nervous system (PNS), Schwann-cell-secreted gliomedin induces the clustering of Na+ channels at the edges of each myelin segment to form nodes of Ranvier. Here we show that bone morphogenetic protein-1 (BMP1)/Tolloid (TLD)-like proteinases confine Na+ channel clustering to these si...

journal_title：Neuron

authors： Eshed-Eisenbach Y,Devaux J,Vainshtein A,Golani O,Lee SJ,Feinberg K,Sukhanov N,Greenspan DS,Susuki K,Rasband MN,Peles E

更新日期：2020-06-03 00:00:00

abstract：:Motor behaviors recruit task-specific neuronal ensembles in motor cortices, which are consolidated over subsequent learning. However, little is known about the molecules that can identify the participating neurons and predict the outcomes of the consolidation process. Using a mouse rotarod-learning task, we showed tha...

journal_title：Neuron

authors： Cao VY,Ye Y,Mastwal S,Ren M,Coon M,Liu Q,Costa RM,Wang KH

更新日期：2015-06-17 00:00:00

abstract：:Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying...

journal_title：Neuron

authors： Hallermann S,Fejtova A,Schmidt H,Weyhersmüller A,Silver RA,Gundelfinger ED,Eilers J

更新日期：2010-11-18 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:Hippocampal replays have been demonstrated to play a crucial role in memory. Chains of ripples (ripple bursts) in CA1 have been reported to co-occur with long-range place cell sequence replays during the quiet awake state, but roles of neural inputs to CA1 in ripple bursts and replays are unknown. Here we show that ri...

journal_title：Neuron

authors： Yamamoto J,Tonegawa S

更新日期：2017-09-27 00:00:00

abstract：:LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...

journal_title：Neuron

authors： Sarmiere PD,Bamburg JR

更新日期：2002-07-03 00:00:00

abstract：:Cortical motor areas are thought to contribute "higher-order processing," but what that processing might include is unknown. Previous studies of the smooth pursuit-related discharge of supplementary eye field (SEF) neurons have not distinguished activity associated with the preparation for pursuit from discharge relat...

journal_title：Neuron

authors： Shichinohe N,Akao T,Kurkin S,Fukushima J,Kaneko CR,Fukushima K

更新日期：2009-06-11 00:00:00

abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...

journal_title：Neuron

authors： Petersen RS,Panzeri S,Diamond ME

更新日期：2001-11-08 00:00:00

abstract：:The performance of a task is often assumed to be a prerequisite for the learning of many tasks, including the associative conditioning of courtship in the fruit fly, Drosophila melanogaster. Transgenic flies specifically inhibited for the enzyme protein kinase C dissociate the acquisition of learning and memory from p...

journal_title：Neuron

authors： Kane NS,Robichon A,Dickinson JA,Greenspan RJ

更新日期：1997-02-01 00:00:00

abstract：:Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...

journal_title：Neuron

authors： Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

更新日期：2010-01-14 00:00:00

abstract：:AMPA-type glutamate receptors (AMPARs) play a major role in excitatory synaptic transmission and plasticity. Channel properties are largely dictated by their composition of the four subunits, GluR1-4 (or A-D). Here we show that AMPAR assembly and subunit stoichiometry are determined by RNA editing in the pore loop. We...

journal_title：Neuron

authors： Greger IH,Khatri L,Kong X,Ziff EB

更新日期：2003-11-13 00:00:00

abstract：:In the precedence effect, sounds emanating directly from the source are localized preferentially over their reflections. Although most studies have focused on the delay between the onset of a sound and its echo, humans still experience the precedence effect when this onset delay is removed. We tested in barn owls the ...

journal_title：Neuron

authors： Nelson BS,Takahashi TT

更新日期：2010-08-26 00:00:00

abstract：:The capsaicin receptor, TRPV1, is regulated by phosphatidylinositol-4,5-bisphosphate (PIP(2)), although the precise nature of this effect (i.e., positive or negative) remains controversial. Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, ...

journal_title：Neuron

authors： Cao E,Cordero-Morales JF,Liu B,Qin F,Julius D

更新日期：2013-02-20 00:00:00

abstract：:Particle-mediated gene transfer and two-photon microscopy were used to monitor the behavior of dendrites of individual cortical pyramidal neurons coexpressing green fluorescent protein (GFP) and brain-derived neurotrophic factor (BDNF). While the dendrites and spines of neurons expressing GFP alone grew modestly over ...

journal_title：Neuron

authors： Horch HW,Krüttgen A,Portbury SD,Katz LC

更新日期：1999-06-01 00:00:00

abstract：:A circadian clock governs most aspects of mammalian behavior. Although its properties are in part genetically determined, altered light-dark environment can change circadian period length through a mechanism requiring de novo DNA methylation. We show here that this mechanism is mediated not via cell-autonomous clock p...

journal_title：Neuron

authors： Azzi A,Evans JA,Leise T,Myung J,Takumi T,Davidson AJ,Brown SA

更新日期：2017-01-18 00:00:00

abstract：:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...

journal_title：Neuron

authors： Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

更新日期：2000-05-01 00:00:00

abstract：:Many activity-dependent changes in synaptic efficacy occur through elevations in postsynaptic calcium triggered by glutamate receptor activation. Here, the postsynaptic, neuron-specific microtubule-associated protein MAP2 is identified as a target of bidirectional calcium-dependent signaling pathways activated by glut...

journal_title：Neuron

authors： Quinlan EM,Halpain S

更新日期：1996-02-01 00:00:00

abstract：:We perceive motion when presented with spatiotemporal changes in contrast (second-order cue). This requires linear signals to be rectified and then summed in temporal order to compute direction. Although both operations have been attributed to cortex, rectification might occur in retina, prior to the ganglion cell. He...

journal_title：Neuron

authors： Demb JB,Zaghloul K,Sterling P

更新日期：2001-11-20 00:00:00

abstract：:The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons; however, the specific PVT efferents regulating reward seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity ...

journal_title：Neuron

authors： Do-Monte FH,Minier-Toribio A,Quiñones-Laracuente K,Medina-Colón EM,Quirk GJ

更新日期：2017-04-19 00:00:00

abstract：:Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...

journal_title：Neuron

authors： Wiegert JS,Mahn M,Prigge M,Printz Y,Yizhar O

更新日期：2017-08-02 00:00:00

abstract：:The idea that memory is stored in the brain as physical alterations goes back at least as far as Plato, but further conceptualization of this idea had to wait until the 20(th) century when two guiding theories were presented: the "engram theory" of Richard Semon and Donald Hebb's "synaptic plasticity theory." While a ...

journal_title：Neuron

authors： Tonegawa S,Liu X,Ramirez S,Redondo R

更新日期：2015-09-02 00:00:00

abstract：:The immediate early gene Arc (also Arg3.1) produces rapid changes in synaptic properties that are linked to de novo translation. Here we develop a novel translation reporter that exploits the rapid maturation and "flash" kinetics of Gaussia luciferase (Gluc) to visualize Arc translation. Following glutamate stimulatio...

journal_title：Neuron

authors： Na Y,Park S,Lee C,Kim DK,Park JM,Sockanathan S,Huganir RL,Worley PF

更新日期：2016-08-03 00:00:00

abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...

journal_title：Neuron

authors： Nicholson-Fish JC,Kokotos AC,Gillingwater TH,Smillie KJ,Cousin MA

更新日期：2015-12-02 00:00:00

abstract：:Abnormally phosphorylated tau proteins (A68) are the building blocks of Alzheimer's disease (AD) paired helical filaments. The biological consequences of the conversion of normal adult tau to A68 remain unknown. Here we demonstrate that native A68 does not bind to microtubules (MTs), yet dephosphorylated A68 regains t...

journal_title：Neuron

authors： Bramblett GT,Goedert M,Jakes R,Merrick SE,Trojanowski JQ,Lee VM

更新日期：1993-06-01 00:00:00

abstract：:Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...

journal_title：Neuron

authors： Ballivet M,Nef P,Couturier S,Rungger D,Bader CR,Bertrand D,Cooper E

更新日期：1988-11-01 00:00:00

abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...

journal_title：Neuron

authors： de Luca E,Ravasenga T,Petrini EM,Polenghi A,Nieus T,Guazzi S,Barberis A

更新日期：2017-07-05 00:00:00

abstract：:A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development. Here, we demonstrate that Reelin binds directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and...

journal_title：Neuron

authors： D'Arcangelo G,Homayouni R,Keshvara L,Rice DS,Sheldon M,Curran T

更新日期：1999-10-01 00:00:00

abstract：:Cholinergic interneurons (CHIs) play a major role in motor and learning functions of the striatum. As acetylcholine does not directly evoke postsynaptic events at most striatal synapses, it remains unclear how postsynaptic cholinergic receptors encode the firing patterns of CHIs in the striatum. To examine the dynamic...

journal_title：Neuron

authors： Mamaligas AA,Ford CP

更新日期：2016-08-03 00:00:00

abstract：:In response to changes in membrane potential, voltage-dependent ion channel proteins undergo conformational rearrangements that lead to channel opening. These rearrangements move a net charge, measured as "gating current", across the membrane. Here we characterize the effects of the pharmacological blocker 4-aminopyri...

journal_title：Neuron

authors： McCormack K,Joiner WJ,Heinemann SH

更新日期：1994-02-01 00:00:00