Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.


:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courting target. By reducing the number of neurons expressing dTrpA1 by MARCM, we demonstrated that the initiation of courtship behavior is significantly correlated with the activation of the transmidline P1 interneurons, the descending P2b interneurons, or both, indicating that these interneurons trigger courtship. Using an experimental paradigm in which a tethered male can be stimulated to initiate courtship by touching his foreleg tarsus to a female's abdomen, we found that P1 neurites of tethered males showed a transient Ca(2+) rise after tarsal stimulation with the female-associated sensory cues. These observations strongly suggest that P1 neurons are the prime components of the neural circuitry that initiates male courtship.






Kohatsu S,Koganezawa M,Yamamoto D




Has Abstract


2011-02-10 00:00:00
















  • A Neuroethics Backbone for the Evolving Canadian Brain Research Strategy.

    abstract::Building on Canada's strong traditions in neuroscience and ethics, neuroethics provides a backbone for the evolving Canadian Brain Research Strategy (CBRS) that, from the outset, incorporates ethically responsible discoveries in brain science into clinical, societal, educational, and commercial innovation. ...


    pub_type: 杂志文章


    authors: Illes J,Weiss S,Bains J,Chandler JA,Conrod P,De Koninck Y,Fellows LK,Groetzinger D,Racine E,Robillard JM,Sokolowski MB

    更新日期:2019-02-06 00:00:00

  • Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development.

    abstract::Bcl-2 is a major regulator of programmed cell death, a critical process in shaping the developing nervous system. To assess whether Bcl-2 is involved in regulating neuronal survival and in mediating the neuroprotective action of neurotrophic factors, we generated Bcl-2-deficient mice. At birth, the number of facial mo...


    pub_type: 杂志文章


    authors: Michaelidis TM,Sendtner M,Cooper JD,Airaksinen MS,Holtmann B,Meyer M,Thoenen H

    更新日期:1996-07-01 00:00:00

  • Enigmas of the dentate gyrus.

    abstract::We are rapidly approaching a better understanding of the mechanisms that allow our brains to form distinct representations for similar events or episodes. McHugh et al. have brought that goal one step closer by showing that NMDA receptor-dependent synaptic plasticity in the dentate gyrus is necessary for immediate dif...


    pub_type: 杂志文章


    authors: Leutgeb JK,Moser EI

    更新日期:2007-07-19 00:00:00

  • Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions.

    abstract::Recent studies suggest that increased activity of cyclin-dependent kinase 5 (Cdk5) may contribute to neuronal death and cytoskeletal abnormalities in Alzheimer's disease. We report here such deregulation of Cdk5 activity associated with the hyperphosphorylation of tau and neurofilament (NF) proteins in mice expressing...


    pub_type: 杂志文章


    authors: Nguyen MD,Larivière RC,Julien JP

    更新日期:2001-04-01 00:00:00

  • Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

    abstract::Each residue in and flanking the M2 membrane-spanning segment of the alpha subunit, from Glu-241 to Glu-262, was mutated to cysteine, and the mutant subunits were expressed together with wild-type beta, gamma, and delta subunits in Xenopus oocytes. Cysteines substituted for Glu-262, Leu-258, Val-255, Ser-252, Leu-251,...


    pub_type: 杂志文章


    authors: Akabas MH,Kaufmann C,Archdeacon P,Karlin A

    更新日期:1994-10-01 00:00:00

  • Excitement about inhibitory presynaptic terminals.

    abstract::Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (...


    pub_type: 评论,杂志文章


    authors: Vandael DH,Espinoza C,Jonas P

    更新日期:2015-03-18 00:00:00

  • Decision making: singin' in the brain.

    abstract::Which neurons in the brain "decide" to initiate particular behaviors in response to sensory information? In this issue of Neuron, two papers (Kohatsu et al. and von Philipsborn et al.) identify candidates in the courtship circuitry of Drosophila. The activity of these neurons is both regulated by sex pheromones and ne...


    pub_type: 评论,杂志文章


    authors: Benton R

    更新日期:2011-02-10 00:00:00

  • Head, neck, and spines: a role for LIMK-1 in the hippocampus.

    abstract::LIM kinase 1 regulates actin filament dynamics through inhibition of ADF/cofilins. Surprisingly, nervous system development in LIM kinase 1 knockout mice is grossly normal, but the animals have deficits in spatial learning, alterations in LTP, and abnormalities in hippocampal dendritic spine structure. The findings ar...


    pub_type: 评论,杂志文章,评审


    authors: Sarmiere PD,Bamburg JR

    更新日期:2002-07-03 00:00:00

  • Selective replenishment of two vesicle pools depends on the source of Ca2+ at the Drosophila synapse.

    abstract::After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in...


    pub_type: 杂志文章


    authors: Kuromi H,Kidokoro Y

    更新日期:2002-07-18 00:00:00

  • A central source of movement variability.

    abstract::Movements are universally, sometimes frustratingly, variable. When such variability causes error, we typically assume that something went wrong during the movement. The same assumption is made by recent and influential models of motor control. These posit that the principal limit on repeatable performance is neuromusc...


    pub_type: 杂志文章


    authors: Churchland MM,Afshar A,Shenoy KV

    更新日期:2006-12-21 00:00:00

  • p190RhoGAP Filters Competing Signals to Resolve Axon Guidance Conflicts.

    abstract::The rich functional diversity of the nervous system is founded in the specific connectivity of the underlying neural circuitry. Neurons are often preprogrammed to respond to multiple axon guidance signals because they use sequential guideposts along their pathways, but this necessitates a strict spatiotemporal regulat...


    pub_type: 杂志文章


    authors: Bonanomi D,Valenza F,Chivatakarn O,Sternfeld MJ,Driscoll SP,Aslanian A,Lettieri K,Gullo M,Badaloni A,Lewcock JW,Hunter T,Pfaff SL

    更新日期:2019-05-08 00:00:00

  • Distinct Nanoscale Calcium Channel and Synaptic Vesicle Topographies Contribute to the Diversity of Synaptic Function.

    abstract::The nanoscale topographical arrangement of voltage-gated calcium channels (VGCC) and synaptic vesicles (SVs) determines synaptic strength and plasticity, but whether distinct spatial distributions underpin diversity of synaptic function is unknown. We performed single bouton Ca2+ imaging, Ca2+ chelator competition, im...


    pub_type: 杂志文章


    authors: Rebola N,Reva M,Kirizs T,Szoboszlay M,Lőrincz A,Moneron G,Nusser Z,DiGregorio DA

    更新日期:2019-11-20 00:00:00

  • Human medial frontal cortex mediates unconscious inhibition of voluntary action.

    abstract::Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain...


    pub_type: 杂志文章


    authors: Sumner P,Nachev P,Morris P,Peters AM,Jackson SR,Kennard C,Husain M

    更新日期:2007-06-07 00:00:00

  • Currently Unstable: Daily Ups and Downs in E-I Balance.

    abstract::Balance between excitation and inhibition (E-I balance) in neural circuits is believed to be tightly regulated. To the contrary, in this issue of Neuron, Bridi et al. (2020) reveal that inverse oscillations of synaptic inhibition and excitation lead to peaks and valleys in E-I balance across the 24 h day. ...


    pub_type: 评论,杂志文章


    authors: Brunwasser SJ,Hengen KB

    更新日期:2020-02-19 00:00:00

  • Getting RIP'd Stunts Your Growth.

    abstract::The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RI...


    pub_type: 评论,杂志文章


    authors: Ceni C,Barker PA

    更新日期:2005-06-16 00:00:00

  • Skilled Movements Require Non-apoptotic Bax/Bak Pathway-Mediated Corticospinal Circuit Reorganization.

    abstract::Early postnatal mammals, including human babies, can perform only basic motor tasks. The acquisition of skilled behaviors occurs later, requiring anatomical changes in neural circuitry to support the development of coordinated activation or suppression of functionally related muscle groups. How this circuit reorganiza...


    pub_type: 杂志文章


    authors: Gu Z,Serradj N,Ueno M,Liang M,Li J,Baccei ML,Martin JH,Yoshida Y

    更新日期:2017-05-03 00:00:00

  • An arousing discovery on catalepsy: orexin regulates vestibular motor functions.

    abstract::A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...


    pub_type: 评论,杂志文章


    authors: Gao XB,Horvath TL

    更新日期:2011-02-24 00:00:00

  • G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.

    abstract::G protein-coupled receptors (GPCRs) mediate diverse signaling processes, including olfaction. G protein-coupled receptor kinases (GRKs) are important regulators of G protein signal transduction that specifically phosphorylate activated GPCRs to terminate signaling. Despite previously described roles for GRKs in GPCR s...


    pub_type: 杂志文章


    authors: Fukuto HS,Ferkey DM,Apicella AJ,Lans H,Sharmeen T,Chen W,Lefkowitz RJ,Jansen G,Schafer WR,Hart AC

    更新日期:2004-05-27 00:00:00

  • NPAS1 represses the generation of specific subtypes of cortical interneurons.

    abstract::Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signali...


    pub_type: 杂志文章


    authors: Stanco A,Pla R,Vogt D,Chen Y,Mandal S,Walker J,Hunt RF,Lindtner S,Erdman CA,Pieper AA,Hamilton SP,Xu D,Baraban SC,Rubenstein JL

    更新日期:2014-12-03 00:00:00

  • Hippocampal SWR activity predicts correct decisions during the initial learning of an alternation task.

    abstract::The hippocampus frequently replays memories of past experiences during sharp-wave ripple (SWR) events. These events can represent spatial trajectories extending from the animal's current location to distant locations, suggesting a role in the evaluation of upcoming choices. While SWRs have been linked to learning and ...


    pub_type: 杂志文章


    authors: Singer AC,Carr MF,Karlsson MP,Frank LM

    更新日期:2013-03-20 00:00:00

  • Semantic memory and the human hippocampus.

    abstract::It has been unclear whether the hippocampus is uniquely important for episodic memory (memory for events that are specific to time and place) or whether the hippocampus is also important for learning and remembering facts (semantic memory). In two studies, we assessed the capacity for semantic memory in patients with ...


    pub_type: 杂志文章


    authors: Manns JR,Hopkins RO,Squire LR

    更新日期:2003-04-10 00:00:00

  • Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.

    abstract::A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...


    pub_type: 杂志文章


    authors: Pierce ME,Sheshberadaran H,Zhang Z,Fox LE,Applebury ML,Takahashi JS

    更新日期:1993-04-01 00:00:00

  • Crossmodal associative memory representations in rodent orbitofrontal cortex.

    abstract::Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...


    pub_type: 杂志文章


    authors: Lipton PA,Alvarez P,Eichenbaum H

    更新日期:1999-02-01 00:00:00

  • MAP'ing CNS development and cognition: an ERKsome process.

    abstract::The ERK MAP kinase signaling cascade plays critical roles in brain development, learning, memory, and cognition. It has recently been appreciated that mutation or deletion of elements within this signaling pathway leads to developmental syndromes in humans that are associated with impaired cognitive function and autis...


    pub_type: 杂志文章,评审


    authors: Samuels IS,Saitta SC,Landreth GE

    更新日期:2009-01-29 00:00:00

  • Signatures of a Statistical Computation in the Human Sense of Confidence.

    abstract::Human confidence judgments are thought to originate from metacognitive processes that provide a subjective assessment about one's beliefs. Alternatively, confidence is framed in mathematics as an objective statistical quantity: the probability that a chosen hypothesis is correct. Despite similar terminology, it remain...


    pub_type: 杂志文章


    authors: Sanders JI,Hangya B,Kepecs A

    更新日期:2016-05-04 00:00:00

  • Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli.

    abstract::Midbrain dopamine (DA) neurons are not homogeneous but differ in their molecular properties and responses to external stimuli. We examined whether the modulation of excitatory synapses on DA neurons by rewarding or aversive stimuli depends on the brain area to which these DA neurons project. We identified DA neuron su...


    pub_type: 杂志文章


    authors: Lammel S,Ion DI,Roeper J,Malenka RC

    更新日期:2011-06-09 00:00:00

  • Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex.

    abstract::We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...


    pub_type: 杂志文章


    authors: Lamprecht R,Farb CR,LeDoux JE

    更新日期:2002-11-14 00:00:00

  • A membrane glycoprotein associated with the limbic system mediates the formation of the septo-hippocampal pathway in vitro.

    abstract::The ability of a neuronal surface glycoprotein to mediate the formation of neuronal connections was tested in an explant culture system. A monoclonal antibody against the limbic system-associated membrane protein (LAMP) was used in co-cultures containing cholinergic neurons of the septum and their hippocampal target n...


    pub_type: 杂志文章


    authors: Keller F,Rimvall K,Barbe MF,Levitt P

    更新日期:1989-11-01 00:00:00

  • Hippocampal and ventral medial prefrontal activation during retrieval-mediated learning supports novel inference.

    abstract::Memory enables flexible use of past experience to inform new behaviors. Although leading theories hypothesize that this fundamental flexibility results from the formation of integrated memory networks relating multiple experiences, the neural mechanisms that support memory integration are not well understood. Here, we...


    pub_type: 杂志文章,随机对照试验


    authors: Zeithamova D,Dominick AL,Preston AR

    更新日期:2012-07-12 00:00:00

  • How quickly can GABAA receptors open?

    abstract::We have examined GABAA receptor activation by making rapid applications of GABA to outside-out patches excised from cultured postnatal rat cerebellar neurons. The rate of development of current increases with increasing GABA concentration from a low to a high concentration asymptote. The low concentration asymptote is...


    pub_type: 杂志文章


    authors: Maconochie DJ,Zempel JM,Steinbach JH

    更新日期:1994-01-01 00:00:00