Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila.


:We determined the cellular substrate for male courtship behavior by quasinatural and artificial stimulation of brain neurons. Activation of fruitless (fru)-expressing neurons via stimulation of thermosensitive dTrpA1 channels induced an entire series of courtship acts in male Drosophila placed alone without any courting target. By reducing the number of neurons expressing dTrpA1 by MARCM, we demonstrated that the initiation of courtship behavior is significantly correlated with the activation of the transmidline P1 interneurons, the descending P2b interneurons, or both, indicating that these interneurons trigger courtship. Using an experimental paradigm in which a tethered male can be stimulated to initiate courtship by touching his foreleg tarsus to a female's abdomen, we found that P1 neurites of tethered males showed a transient Ca(2+) rise after tarsal stimulation with the female-associated sensory cues. These observations strongly suggest that P1 neurons are the prime components of the neural circuitry that initiates male courtship.






Kohatsu S,Koganezawa M,Yamamoto D




Has Abstract


2011-02-10 00:00:00
















  • The role of tangential migration in the establishment of mammalian cortex.

    abstract::In the developing nervous system, neurons are generated at sites distant from their ultimate location. In the vertebrate CNS, neurons utilize distinct migration strategies to reach their ultimate residence. This review discusses the contribution of tangential migration to the architectural development of the cerebral ...


    pub_type: 评论,杂志文章,评审


    authors: Maricich SM,Gilmore EC,Herrup K

    更新日期:2001-08-02 00:00:00

  • Oscillatory substrates of fear and safety.

    abstract::Oscillatory activity in the basolateral amygdala (BLA) is critical for emotional behavior. In this issue of Neuron, Stujenske et al. (2014) describe novel dynamics of BLA theta-gamma-coupled neuronal oscillations associated with conditioned and innate fear. ...


    pub_type: 评论,杂志文章


    authors: Bocchio M,Capogna M

    更新日期:2014-08-20 00:00:00

  • A Circuit for Integration of Head- and Visual-Motion Signals in Layer 6 of Mouse Primary Visual Cortex.

    abstract::To interpret visual-motion events, the underlying computation must involve internal reference to the motion status of the observer's head. We show here that layer 6 (L6) principal neurons in mouse primary visual cortex (V1) receive a diffuse, vestibular-mediated synaptic input that signals the angular velocity of hori...


    pub_type: 杂志文章


    authors: Vélez-Fort M,Bracey EF,Keshavarzi S,Rousseau CV,Cossell L,Lenzi SC,Strom M,Margrie TW

    更新日期:2018-04-04 00:00:00

  • Parvalbumin Interneurons: All Forest, No Trees.

    abstract::There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...


    pub_type: 评论,杂志文章


    authors: Trachtenberg JT

    更新日期:2015-07-15 00:00:00

  • Activating Injury-Responsive Genes with Hypoxia Enhances Axon Regeneration through Neuronal HIF-1α.

    abstract::Injured peripheral neurons successfully activate a proregenerative transcriptional program to enable axon regeneration and functional recovery. How transcriptional regulators coordinate the expression of such program remains unclear. Here we show that hypoxia-inducible factor 1α (HIF-1α) controls multiple injury-induc...


    pub_type: 杂志文章


    authors: Cho Y,Shin JE,Ewan EE,Oh YM,Pita-Thomas W,Cavalli V

    更新日期:2015-11-18 00:00:00

  • Clinical Concepts Emerging from fMRI Functional Connectomics.

    abstract::Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...


    pub_type: 杂志文章,评审


    authors: Matthews PM,Hampshire A

    更新日期:2016-08-03 00:00:00

  • Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks.

    abstract::In the CNS, activity of individual neurons has a small but quantifiable relationship to sensory representations and motor outputs. Coactivation of a few 10s to 100s of neurons can code sensory inputs and behavioral task performance within psychophysical limits. However, in a sea of sensory inputs and demand for comple...


    pub_type: 杂志文章,评审


    authors: Ainsworth M,Lee S,Cunningham MO,Traub RD,Kopell NJ,Whittington MA

    更新日期:2012-08-23 00:00:00

  • Cortical maps and white matter tracts following long period of visual deprivation and retinal image restoration.

    abstract::Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...


    pub_type: 杂志文章


    authors: Levin N,Dumoulin SO,Winawer J,Dougherty RF,Wandell BA

    更新日期:2010-01-14 00:00:00

  • Development of direction selectivity in mouse cortical neurons.

    abstract::Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience. Here, we used two-photon calcium imaging to study the development of direction selectivity in layer 2/3 neurons of the mouse visual cortex in vivo. Surprisingly, just after eye opening nearly...


    pub_type: 杂志文章


    authors: Rochefort NL,Narushima M,Grienberger C,Marandi N,Hill DN,Konnerth A

    更新日期:2011-08-11 00:00:00

  • Attraction of position preference by spatial attention throughout human visual cortex.

    abstract::Voluntary spatial attention concentrates neural resources at the attended location. Here, we examined the effects of spatial attention on spatial position selectivity in humans. We measured population receptive fields (pRFs) using high-field functional MRI (fMRI) (7T) while subjects performed an attention-demanding ta...


    pub_type: 杂志文章,随机对照试验


    authors: Klein BP,Harvey BM,Dumoulin SO

    更新日期:2014-10-01 00:00:00

  • The neurotransmitter cycle and quantal size.

    abstract::Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...


    pub_type: 杂志文章,评审


    authors: Edwards RH

    更新日期:2007-09-20 00:00:00

  • FTD and ALS: genetic ties that bind.

    abstract::Curiously, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), seemingly disparate neurodegenerative disorders, can be inherited together. Two groups (DeJesus-Hernandez et al. and Renton et al.) show that the long sought after ALS/FTD mutation on chromosomal region 9p is a hexanucleotide expansion i...


    pub_type: 评论,杂志文章


    authors: Orr HT

    更新日期:2011-10-20 00:00:00

  • Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.

    abstract::Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic ...


    pub_type: 杂志文章


    authors: Frank CA,Kennedy MJ,Goold CP,Marek KW,Davis GW

    更新日期:2006-11-22 00:00:00

  • Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons.

    abstract::M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not u...


    pub_type: 杂志文章


    authors: Marrion NV

    更新日期:1993-07-01 00:00:00

  • Proprioceptive coupling within motor neurons drives C. elegans forward locomotion.

    abstract::Locomotion requires coordinated motor activity throughout an animal's body. In both vertebrates and invertebrates, chains of coupled central pattern generators (CPGs) are commonly evoked to explain local rhythmic behaviors. In C. elegans, we report that proprioception within the motor circuit is responsible for propag...


    pub_type: 杂志文章


    authors: Wen Q,Po MD,Hulme E,Chen S,Liu X,Kwok SW,Gershow M,Leifer AM,Butler V,Fang-Yen C,Kawano T,Schafer WR,Whitesides G,Wyart M,Chklovskii DB,Zhen M,Samuel AD

    更新日期:2012-11-21 00:00:00

  • Large-scale mirror-symmetry organization of human occipito-temporal object areas.

    abstract::We have combined functional maps of retinotopy (eccentricity and meridian mapping), object category, and motion in a group of subjects to explore the large-scale topography of higher-order object areas. Our results reveal seven consistent category-related entities situated in the occipito-temporal cortex adjoining ear...


    pub_type: 杂志文章


    authors: Hasson U,Harel M,Levy I,Malach R

    更新日期:2003-03-27 00:00:00

  • Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex.

    abstract::I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybd...


    pub_type: 杂志文章


    authors: Chen H,Kim LA,Rajan S,Xu S,Goldstein SA

    更新日期:2003-09-25 00:00:00

  • Alpha cells take off first.

    abstract::Using a transgenic mouse line in which GFP is expressed in a single population of retinal ganglion cells (RGCs), Huberman and colleagues report in this issue of Neuron that the axon terminals of RGCs exhibit an orderly pattern of distribution in the higher visual centers. This pattern undergoes a developmental refinem...


    pub_type: 评论,杂志文章


    authors: He S

    更新日期:2008-08-14 00:00:00

  • Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1.

    abstract::Sonic hedgehog (Shh) is a putative morphogen secreted by the floor plate and notochord, which specifies the fate of multiple cell types in the ventral aspect of the vertebrate nervous system. Since in Drosophila the actions of Hh have been shown to be transduced by Cubitus interruptus (Ci), a zinc finger transcription...


    pub_type: 杂志文章


    authors: Hynes M,Stone DM,Dowd M,Pitts-Meek S,Goddard A,Gurney A,Rosenthal A

    更新日期:1997-07-01 00:00:00

  • Figuring space by time.

    abstract::Sensory information is encoded both in space and in time. Spatial encoding is based on the identity of activated receptors, while temporal encoding is based on the timing of activation. In order to generate accurate internal representations of the external world, the brain must decode both types of encoded information...


    pub_type: 杂志文章,评审


    authors: Ahissar E,Arieli A

    更新日期:2001-10-25 00:00:00

  • Basolateral amygdala neurons facilitate reward-seeking behavior by exciting nucleus accumbens neurons.

    abstract::Both the nucleus accumbens (NAc) and basolateral amygdala (BLA) contribute to learned behavioral choice. Neurons in both structures that encode reward-predictive cues may underlie the decision to respond to such cues, but the neural circuits by which the BLA influences reward-seeking behavior have not been established...


    pub_type: 杂志文章


    authors: Ambroggi F,Ishikawa A,Fields HL,Nicola SM

    更新日期:2008-08-28 00:00:00

  • Context-dependent encoding in the human auditory brainstem relates to hearing speech in noise: implications for developmental dyslexia.

    abstract::We examined context-dependent encoding of speech in children with and without developmental dyslexia by measuring auditory brainstem responses to a speech syllable presented in a repetitive or variable context. Typically developing children showed enhanced brainstem representation of features related to voice pitch in...


    pub_type: 杂志文章


    authors: Chandrasekaran B,Hornickel J,Skoe E,Nicol T,Kraus N

    更新日期:2009-11-12 00:00:00

  • Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs.

    abstract::During synaptic development, proteins aggregate at specialized pre- and postsynaptic structures. Mechanisms that mediate protein clustering at these sites remain unknown. To investigate this process, we analyzed synaptic targeting of a postsynaptic density protein, PSD-95, by expressing green fluorescent protein- (GFP...


    pub_type: 杂志文章


    authors: Craven SE,El-Husseini AE,Bredt DS

    更新日期:1999-03-01 00:00:00

  • The maintenance of LTP at hippocampal mossy fiber synapses is independent of sustained presynaptic calcium.

    abstract::We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...


    pub_type: 杂志文章


    authors: Regehr WG,Tank DW

    更新日期:1991-09-01 00:00:00

  • NMD Takes the Immune Road to NDD.

    abstract::Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by t...


    pub_type: 评论,杂志文章


    authors: Kim E,Huh JR

    更新日期:2019-11-20 00:00:00

  • Synchronization of olfactory bulb mitral cells by precisely timed inhibitory inputs.

    abstract::Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...


    pub_type: 杂志文章


    authors: Schoppa NE

    更新日期:2006-01-19 00:00:00

  • Glial cells maintain synaptic structure and function and promote development of the neuromuscular junction in vivo.

    abstract::To investigate the in vivo role of glial cells in synaptic function, maintenance, and development, we have developed an approach to selectively ablate perisynaptic Schwann cells (PSCs), the glial cells at the neuromuscular junction (NMJ), en masse from live frog muscles. In adults, following acute PSC ablation, synapt...


    pub_type: 杂志文章


    authors: Reddy LV,Koirala S,Sugiura Y,Herrera AA,Ko CP

    更新日期:2003-10-30 00:00:00

  • Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness.

    abstract::The panoply of cognitive, affective, motivational, and social functions that underpin everyday human experience requires precisely choreographed patterns of interaction between networked brain regions. Perhaps not surprisingly, diverse forms of psychopathology are characterized by breakdowns in these interregional rel...


    pub_type: 杂志文章,评审


    authors: Buckholtz JW,Meyer-Lindenberg A

    更新日期:2012-06-21 00:00:00

  • Asymmetric clathrin-mediated endocytosis drives repulsive growth cone guidance.

    abstract::Asymmetric Ca(2+) elevations across the axonal growth cone mediate its turning responses to attractive and repulsive guidance cues. Here we show that clathrin-mediated endocytosis acts downstream of Ca(2+) signals as driving machinery for growth cone turning. In dorsal root ganglion neurons, the formation of clathrin-...


    pub_type: 杂志文章


    authors: Tojima T,Itofusa R,Kamiguchi H

    更新日期:2010-05-13 00:00:00

  • TREM2 and Amyloid Beta: A Love-Hate Relationship.

    abstract::Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits. ...


    pub_type: 评论,杂志文章


    authors: Udeochu J,Sayed FA,Gan L

    更新日期:2018-03-07 00:00:00