Abstract:
:We have examined the influence of retinal innervation on the development of target neurons in the first optic ganglion, the lamina, of D. melanogaster. Mitotically active lamina precursor cells (LPCs), which normally produce lamina neurons, are absent in mutants that lack retinal innervation, while other proliferative centers appear unaffected. Reducing the number of innervating photoreceptor axons results in fewer mitotic LPCs. In glass mutants photoreceptors project to abnormal locations and LPCs are found adjacent to these aberrant projections. We conclude that the arrival of photoreceptor axons in the larval brain initiates, directly or indirectly, cell division to produce lamina neurons. Our results provide an explanation for how the synchronous development of these two interacting systems is coordinated.
journal_name
Neuronjournal_title
Neuronauthors
Selleck SB,Steller Hdoi
10.1016/0896-6273(91)90124-isubject
Has Abstractpub_date
1991-01-01 00:00:00pages
83-99issue
1eissn
0896-6273issn
1097-4199pii
0896-6273(91)90124-Ijournal_volume
6pub_type
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