Melatonin is required for the circadian regulation of sleep.

Abstract:

:Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.

journal_name

Neuron

journal_title

Neuron

authors

Gandhi AV,Mosser EA,Oikonomou G,Prober DA

doi

10.1016/j.neuron.2015.02.016

subject

Has Abstract

pub_date

2015-03-18 00:00:00

pages

1193-9

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896-6273(15)00131-2

journal_volume

85

pub_type

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