Abstract:
:Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.
journal_name
Neuronjournal_title
Neuronauthors
Gandhi AV,Mosser EA,Oikonomou G,Prober DAdoi
10.1016/j.neuron.2015.02.016subject
Has Abstractpub_date
2015-03-18 00:00:00pages
1193-9issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00131-2journal_volume
85pub_type
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