Abstract：
:Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.
journal_name
Neuronjournal_title
Neuronauthors
Gandhi AV,Mosser EA,Oikonomou G,Prober DAdoi
10.1016/j.neuron.2015.02.016subject
Has Abstractpub_date
2015-03-18 00:00:00pages
1193-9issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00131-2journal_volume
85pub_type
杂志文章相关文献
NEURON文献大全abstract：:A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.04.010
更新日期：2013-06-05 00:00:00
abstract：:The study of interneuron diversity in the spinal cord is complex and needs new models that can accelerate discovery. In this issue, Hoang et al. (2018) use ESC-derived neurons to create simplified microcircuits to study spinal interneuron diversification, connectivity, and function. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.09.034
更新日期：2018-10-10 00:00:00
abstract：:The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(02)00672-4
更新日期：2002-05-16 00:00:00
abstract：:Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2004.08.018
更新日期：2004-09-02 00:00:00
abstract：:Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.03.019
更新日期：2005-04-21 00:00:00
abstract：:The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.09.012
更新日期：2015-09-23 00:00:00
abstract：:In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2018.03.012
更新日期：2018-03-21 00:00:00
abstract：:Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.02.040
更新日期：2016-04-06 00:00:00
abstract：:The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2018.12.004
更新日期：2019-02-06 00:00:00
abstract：:We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2005.09.028
更新日期：2005-12-08 00:00:00
abstract：:EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2012.02.003
更新日期：2012-02-23 00:00:00
abstract：:About two-thirds of the antibodies to the nicotinic acetylcholine (ACh) receptor in patients with the autoimmune disease myasthenia gravis bind to the main immunogenic region (MIR). This is small, well-defined region on each of the two alpha subunits, containing residues 67-76 (alpha 67-76). By determining the structu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90037-3
更新日期：1995-08-01 00:00:00
abstract：:Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.12.029
更新日期：2016-02-17 00:00:00
abstract：:New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2015.03.029
更新日期：2015-04-08 00:00:00
abstract：:AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90175-y
更新日期：1991-05-01 00:00:00
abstract：:Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.03.021
更新日期：2020-06-17 00:00:00
abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2013.05.024
更新日期：2013-07-10 00:00:00
abstract：:Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...
journal_title：Neuron
pub_type： 历史文章,杂志文章
doi：10.1016/j.neuron.2010.08.028
更新日期：2010-09-09 00:00:00
abstract：:Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90081-p
更新日期：1990-10-01 00:00:00
abstract：:Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80503-6
更新日期：1998-06-01 00:00:00
abstract：:This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(01)00481-0
更新日期：2001-11-08 00:00:00
abstract：:We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90058-n
更新日期：1990-03-01 00:00:00
abstract：:We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90100-t
更新日期：1990-02-01 00:00:00
abstract：:Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90312-f
更新日期：1993-02-01 00:00:00
abstract：:Delineating the molecular basis of synapse development is crucial for understanding brain function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the coculture ass...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2009.01.017
更新日期：2009-03-12 00:00:00
abstract：:A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...
journal_title：Neuron
pub_type： 杂志文章,meta分析
doi：10.1016/j.neuron.2017.09.032
更新日期：2017-10-11 00:00:00
abstract：:Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80548-6
更新日期：1998-08-01 00:00:00
abstract：:The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.06.022
更新日期：2017-07-05 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.02.008
更新日期：2008-04-24 00:00:00
abstract：:The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...
journal_title：Neuron
pub_type： 评论,杂志文章,评审
doi：10.1016/s0896-6273(03)00364-7
更新日期：2003-06-19 00:00:00
