Melatonin is required for the circadian regulation of sleep.


:Sleep is an evolutionarily conserved behavioral state whose regulation is poorly understood. A classical model posits that sleep is regulated by homeostatic and circadian mechanisms. Several factors have been implicated in mediating the homeostatic regulation of sleep, but molecules underlying the circadian mechanism are unknown. Here we use animals lacking melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is required for circadian regulation of sleep in zebrafish. Sleep is dramatically reduced at night in aanat2 mutants maintained in light/dark conditions, and the circadian regulation of sleep is abolished in free-running conditions. We find that melatonin promotes sleep downstream of the circadian clock as it is not required to initiate or maintain circadian rhythms. Additionally, we provide evidence that melatonin may induce sleep in part by promoting adenosine signaling, thus potentially linking circadian and homeostatic control of sleep.






Gandhi AV,Mosser EA,Oikonomou G,Prober DA




Has Abstract


2015-03-18 00:00:00
















  • Invigoration of reward seeking by cue and proximity encoding in the nucleus accumbens.

    abstract::A key function of the nucleus accumbens is to promote vigorous reward seeking, but the corresponding neural mechanism has not been identified despite many years of research. Here, we study cued flexible approach behavior, a form of reward seeking that strongly depends on the accumbens, and we describe a robust, single...


    pub_type: 杂志文章


    authors: McGinty VB,Lardeux S,Taha SA,Kim JJ,Nicola SM

    更新日期:2013-06-05 00:00:00

  • Spinal Interneurons "à La Carte".

    abstract::The study of interneuron diversity in the spinal cord is complex and needs new models that can accelerate discovery. In this issue, Hoang et al. (2018) use ESC-derived neurons to create simplified microcircuits to study spinal interneuron diversification, connectivity, and function. ...


    pub_type: 评论,杂志文章


    authors: Alvarez FJ

    更新日期:2018-10-10 00:00:00

  • MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion.

    abstract::The netrin UNC-6 repels motor axons by activating the UNC-5 receptor alone or in combination with the UNC-40/DCC receptor. In a genetic screen for C. elegans mutants exhibiting partial defects in motor axon projections, we isolated the max-1 gene (required for motor neuron axon guidance). max-1 loss-of-function mutati...


    pub_type: 杂志文章


    authors: Huang X,Cheng HJ,Tessier-Lavigne M,Jin Y

    更新日期:2002-05-16 00:00:00

  • Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules.

    abstract::Rhythmic spontaneous electrical activity occurs in many parts of the developing nervous system, where it plays essential roles in the refinement of neural connections. By blocking or slowing this bursting activity, via in ovo drug applications at precise developmental periods, we show that such activity is also requir...


    pub_type: 杂志文章


    authors: Hanson MG,Landmesser LT

    更新日期:2004-09-02 00:00:00

  • Vav family GEFs link activated Ephs to endocytosis and axon guidance.

    abstract::Ephrin signaling through Eph receptor tyrosine kinases can promote attraction or repulsion of axonal growth cones during development. However, the mechanisms that determine whether Eph signaling promotes attraction or repulsion are not known. We show here that the Rho family GEF Vav2 plays a key role in this process. ...


    pub_type: 杂志文章


    authors: Cowan CW,Shao YR,Sahin M,Shamah SM,Lin MZ,Greer PL,Gao S,Griffith EC,Brugge JS,Greenberg ME

    更新日期:2005-04-21 00:00:00

  • Waking State: Rapid Variations Modulate Neural and Behavioral Responses.

    abstract::The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by wh...


    pub_type: 杂志文章,评审


    authors: McGinley MJ,Vinck M,Reimer J,Batista-Brito R,Zagha E,Cadwell CR,Tolias AS,Cardin JA,McCormick DA

    更新日期:2015-09-23 00:00:00

  • Dissecting Modulatory Effects of Visual Attention in Primate Lateral Prefrontal Cortex Using Signal Detection Theory.

    abstract::In this issue of Neuron, Luo and Maunsell (2018) use signal detection theory to demonstrate that the modulatory effects of attention on neuronal responses in the lateral prefrontal cortex during change detection can be due to changes in an observer's sensitivity or shifts in their response criterion. ...


    pub_type: 评论,杂志文章


    authors: Martinez-Trujillo J,Gulli RA

    更新日期:2018-03-21 00:00:00

  • GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

    abstract::Loss of maternal UBE3A causes Angelman syndrome (AS), a neurodevelopmental disorder associated with severe epilepsy. We previously implicated GABAergic deficits onto layer (L) 2/3 pyramidal neurons in the pathogenesis of neocortical hyperexcitability, and perhaps epilepsy, in AS model mice. Here we investigate consequ...


    pub_type: 杂志文章


    authors: Judson MC,Wallace ML,Sidorov MS,Burette AC,Gu B,van Woerden GM,King IF,Han JE,Zylka MJ,Elgersma Y,Weinberg RJ,Philpot BD

    更新日期:2016-04-06 00:00:00

  • Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal Indirect Pathway Neurons in Parkinson's Disease Models.

    abstract::The motor symptoms of Parkinson's disease (PD) are thought to stem from an imbalance in the activity of striatal direct- and indirect-pathway spiny projection neurons (SPNs). Disease-induced alterations in the activity of networks controlling SPNs could contribute to this imbalance. One of these networks is anchored b...


    pub_type: 杂志文章


    authors: Tanimura A,Du Y,Kondapalli J,Wokosin DL,Surmeier DJ

    更新日期:2019-02-06 00:00:00

  • Active maintenance of associative mnemonic signal in monkey inferior temporal cortex.

    abstract::We investigated the contribution of the inferior temporal (IT) cortical neurons to the active maintenance of internal representations. The activity of single neurons in the IT cortex was recorded while the monkeys performed a sequential-type associative memory task in which distractor stimuli interrupted the delay epo...


    pub_type: 杂志文章


    authors: Takeda M,Naya Y,Fujimichi R,Takeuchi D,Miyashita Y

    更新日期:2005-12-08 00:00:00

  • EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

    abstract::EPAC proteins are the guanine nucleotide exchange factors that act as the intracellular receptors for cyclic AMP. Two variants of EPAC genes including EPAC1 and EPAC2 are cloned and are widely expressed throughout the brain. But, their functions in the brain remain unknown. Here, we genetically delete EPAC1 (EPAC1(-/-...


    pub_type: 杂志文章


    authors: Yang Y,Shu X,Liu D,Shang Y,Wu Y,Pei L,Xu X,Tian Q,Zhang J,Qian K,Wang YX,Petralia RS,Tu W,Zhu LQ,Wang JZ,Lu Y

    更新日期:2012-02-23 00:00:00

  • Three-dimensional location of the main immunogenic region of the acetylcholine receptor.

    abstract::About two-thirds of the antibodies to the nicotinic acetylcholine (ACh) receptor in patients with the autoimmune disease myasthenia gravis bind to the main immunogenic region (MIR). This is small, well-defined region on each of the two alpha subunits, containing residues 67-76 (alpha 67-76). By determining the structu...


    pub_type: 杂志文章


    authors: Beroukhim R,Unwin N

    更新日期:1995-08-01 00:00:00

  • Dopamine Does Double Duty in Motivating Cognitive Effort.

    abstract::Cognitive control is subjectively costly, suggesting that engagement is modulated in relationship to incentive state. Dopamine appears to play key roles. In particular, dopamine may mediate cognitive effort by two broad classes of functions: (1) modulating the functional parameters of working memory circuits subservin...


    pub_type: 杂志文章,评审


    authors: Westbrook A,Braver TS

    更新日期:2016-02-17 00:00:00

  • Engineering the next generation of brain scientists.

    abstract::New technologies to probe the nervous system are propelling innovation and discovery at blinding speed, but are our trainees prepared to maximize this power? The growing role of engineering in research, such as materials, computing, electronics, and devices, compels us to rethink neuroscience education. Core technolog...


    pub_type: 杂志文章,评审


    authors: Litt B

    更新日期:2015-04-08 00:00:00

  • Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons.

    abstract::AMPA but not kainate produces a rapidly desensitizing response in mouse hippocampal neurons. The characteristic action of these agonists appears to arise from activation of a single receptor with active and desensitized states, for which AMPA and kainate have different relative affinity. The equilibrium potency of a s...


    pub_type: 杂志文章


    authors: Patneau DK,Mayer ML

    更新日期:1991-05-01 00:00:00

  • Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons.

    abstract::Itch and pain are distinct unpleasant sensations that can be triggered from the same receptive fields in the skin, raising the question of how pruriception and nociception are coded and discriminated. Here, we tested the multimodal capacity of peripheral first-order neurons, focusing on the genetically defined subpopu...


    pub_type: 杂志文章


    authors: Sharif B,Ase AR,Ribeiro-da-Silva A,Séguéla P

    更新日期:2020-06-17 00:00:00

  • Contributions of the 12 neuron classes in the fly lamina to motion vision.

    abstract::Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...


    pub_type: 杂志文章


    authors: Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

    更新日期:2013-07-10 00:00:00

  • Neuroscience and education: an ideal partnership for producing evidence-based solutions to Guide 21(st) Century Learning.

    abstract::Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...


    pub_type: 历史文章,杂志文章


    authors: Carew TJ,Magsamen SH

    更新日期:2010-09-09 00:00:00

  • A monoclonal antibody that defines rostrocaudal gradients in the mammalian nervous system.

    abstract::Spinal cord axons display a rostrocaudal, positional bias in their innervation of sympathetic ganglia and intercostal skeletal muscles. In an effort to examine the molecular basis of this positional specificity, we used the cyclophosphamide immunosuppression method to produce monoclonal antibodies that bind preferenti...


    pub_type: 杂志文章


    authors: Suzue T,Kaprielian Z,Patterson PH

    更新日期:1990-10-01 00:00:00

  • The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.

    abstract::Nematode degenerins have been implicated in touch sensitivity and other forms of mechanosensation. Certain mutations in several degenerin genes cause the swelling, vacuolation, and death of neurons, and other mutations in the muscle degenerin gene unc-105 cause hypercontraction. Here, we confirm that unc-105 encodes a...


    pub_type: 杂志文章


    authors: García-Añoveros J,García JA,Liu JD,Corey DP

    更新日期:1998-06-01 00:00:00

  • Population coding of stimulus location in rat somatosensory cortex.

    abstract::This study explores the nature of population coding in sensory cortex by applying information theoretic analyses to neuron pairs recorded simultaneously from rat barrel cortex. We quantified the roles of individual spikes and spike patterns in encoding whisker stimulus location. 82%-85% of the total information was co...


    pub_type: 杂志文章


    authors: Petersen RS,Panzeri S,Diamond ME

    更新日期:2001-11-08 00:00:00

  • Rod photoreceptor development in vitro: intrinsic properties of proliferating neuroepithelial cells change as development proceeds in the rat retina.

    abstract::We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...


    pub_type: 杂志文章


    authors: Watanabe T,Raff MC

    更新日期:1990-03-01 00:00:00

  • Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR.

    abstract::We have analyzed alternatively spliced beta amyloid protein precursor (beta APP) mRNAs by using the polymerase chain reaction to amplify beta APP cDNAs produced by reverse transcription. With this approach the three previously characterized beta APP mRNAs (beta APP695, beta APP751, and beta APP770) are readily detecte...


    pub_type: 杂志文章


    authors: Golde TE,Estus S,Usiak M,Younkin LH,Younkin SG

    更新日期:1990-02-01 00:00:00

  • Localization of TNF alpha and IL-1 alpha immunoreactivities in striatal neurons after surgical injury to the hippocampus.

    abstract::Since the inflammatory process develops after transplantation to the brain, we sought to determine the presence of cytokines following a surgical trauma to the brain of an adult mouse. We report the early and marked presence of tumor necrosis factor-alpha and interleukin-1 alpha in neuronal somata of the striatum foll...


    pub_type: 杂志文章


    authors: Tchelingerian JL,Quinonero J,Booss J,Jacque C

    更新日期:1993-02-01 00:00:00

  • An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers.

    abstract::Delineating the molecular basis of synapse development is crucial for understanding brain function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the coculture ass...


    pub_type: 杂志文章


    authors: Linhoff MW,Laurén J,Cassidy RM,Dobie FA,Takahashi H,Nygaard HB,Airaksinen MS,Strittmatter SM,Craig AM

    更新日期:2009-03-12 00:00:00

  • A Meta-Analysis Suggests Different Neural Correlates for Implicit and Explicit Learning.

    abstract::A meta-analysis of non-human primates performing three different tasks (Object-Match, Category-Match, and Category-Saccade associations) revealed signatures of explicit and implicit learning. Performance improved equally following correct and error trials in the Match (explicit) tasks, but it improved more after corre...


    pub_type: 杂志文章,meta分析


    authors: Loonis RF,Brincat SL,Antzoulatos EG,Miller EK

    更新日期:2017-10-11 00:00:00

  • Interaction of the N-ethylmaleimide-sensitive factor with AMPA receptors.

    abstract::Glutamate receptors mediate the majority of rapid excitatory synaptic transmission in the central nervous system (CNS) and play important roles in synaptic plasticity and neuronal development. Recently, protein-protein interactions with the C-terminal domain of glutamate receptor subunits have been shown to be involve...


    pub_type: 杂志文章


    authors: Song I,Kamboj S,Xia J,Dong H,Liao D,Huganir RL

    更新日期:1998-08-01 00:00:00

  • Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents.

    abstract::The lateral mobility of neurotransmitter receptors has been shown to tune synaptic signals. Here we report that GABAA receptors (GABAARs) can diffuse between adjacent dendritic GABAergic synapses in long-living desensitized states, thus laterally spreading "activation memories" between inhibitory synapses. Glutamaterg...


    pub_type: 杂志文章


    authors: de Luca E,Ravasenga T,Petrini EM,Polenghi A,Nieus T,Guazzi S,Barberis A

    更新日期:2017-07-05 00:00:00

  • Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

    abstract::Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...


    pub_type: 杂志文章


    authors: Albouy G,Sterpenich V,Balteau E,Vandewalle G,Desseilles M,Dang-Vu T,Darsaud A,Ruby P,Luppi PH,Degueldre C,Peigneux P,Luxen A,Maquet P

    更新日期:2008-04-24 00:00:00

  • Curbing the excesses of youth: molecular insights into axonal pruning.

    abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...


    pub_type: 评论,杂志文章,评审


    authors: Kantor DB,Kolodkin AL

    更新日期:2003-06-19 00:00:00