Abstract:
:Based on extrapolation from excitatory synapses, it is often assumed that depletion of the releasable pool of synaptic vesicles is the main factor underlying depression at inhibitory synapses. In this issue of Neuron, using subcellular patch-clamp recording from inhibitory presynaptic terminals, Kawaguchi and Sakaba (2015) show that at Purkinje cell-deep cerebellar nuclei neuron synapses, changes in presynaptic action potential waveform substantially contribute to synaptic depression.
journal_name
Neuronjournal_title
Neuronauthors
Vandael DH,Espinoza C,Jonas Pdoi
10.1016/j.neuron.2015.03.006subject
Has Abstractpub_date
2015-03-18 00:00:00pages
1149-51issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00202-0journal_volume
85pub_type
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