Inactivation of presynaptic calcium current contributes to synaptic depression at a fast central synapse.

abstract：:Postlingually deaf subjects learn the meaning of sounds after cochlear implantation by forming new associations between sounds and their sources. Implants generate coarse frequency responses, preventing place-coding fine enough to discriminate sounds with similar temporal characteristics, e.g., buck/duck. This limitat...

journal_title：Neuron

authors： Giraud AL,Price CJ,Graham JM,Truy E,Frackowiak RS

更新日期：2001-06-01 00:00:00

abstract：:The psychiatric illness risk gene Disrupted in Schizophrenia-1 (DISC1) plays an important role in brain development; however, it is unclear how DISC1 is regulated during cortical development. Here, we report that DISC1 is regulated during embryonic neural progenitor proliferation and neuronal migration through an inte...

journal_title：Neuron

authors： Singh KK,Ge X,Mao Y,Drane L,Meletis K,Samuels BA,Tsai LH

更新日期：2010-07-15 00:00:00

abstract：:A longstanding debate in binocular rivalry literature is whether the perceptual competition in rivalry occurs at an early or late stage of visual processing. Central to this debate is the determination of the source of the competition. Overwhelming evidence exists that local interocular differences can lead to binocul...

journal_title：Neuron

authors： Carlson TA,He S

更新日期：2004-09-16 00:00:00

abstract：:Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...

journal_title：Neuron

authors： Schoppa NE

更新日期：2006-01-19 00:00:00

abstract：:The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generati...

journal_title：Neuron

authors： Lindén H,Tetzlaff T,Potjans TC,Pettersen KH,Grün S,Diesmann M,Einevoll GT

更新日期：2011-12-08 00:00:00

abstract：:The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent to which these receptors can discriminate between BDNF and NGF. We found that a 1000-fold excess of the heterologous ligan...

journal_title：Neuron

authors： Rodriguez-Tébar A,Dechant G,Barde YA

更新日期：1990-04-01 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho,...

journal_title：Neuron

authors： Udo H,Jin I,Kim JH,Li HL,Youn T,Hawkins RD,Kandel ER,Bailey CH

更新日期：2005-03-24 00:00:00

abstract：:Membrane excitability is a fundamentally important feature for all excitable cells including both neurons and muscle cells. However, the background depolarizing conductances in excitable cells, especially in muscle cells, are not well characterized. Although mutations in transmembrane channel-like (TMC) proteins TMC1 ...

journal_title：Neuron

authors： Yue X,Zhao J,Li X,Fan Y,Duan D,Zhang X,Zou W,Sheng Y,Zhang T,Yang Q,Luo J,Duan S,Xiao R,Kang L

更新日期：2018-02-07 00:00:00

abstract：:Changes in the response to release of a single synaptic vesicle have generally been attributed to postsynaptic modification of receptor sensitivity, but considerable evidence now demonstrates that alterations in vesicle filling also contribute to changes in quantal size. Receptors are not saturated at many synapses, a...

journal_title：Neuron

authors： Edwards RH

更新日期：2007-09-20 00:00:00

abstract：:What underlies the large variation in mEPSC amplitude in the auditory system? And is this variability important? In this issue of Neuron, Li et al. (2014) address the significance of large mEPSCs to auditory processing and Chapochnikov et al. (2014) describe a novel mechanism underlying them. ...

journal_title：Neuron

authors： Lv C,Zenisek D

更新日期：2014-09-17 00:00:00

abstract：:Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...

journal_title：Neuron

authors： Ueda HR,Dodt HU,Osten P,Economo MN,Chandrashekar J,Keller PJ

更新日期：2020-05-06 00:00:00

abstract：:The intracellular C-terminal domain structure of a six-transmembrane K+ channel from Escherichia coli has been solved by X-ray crystallography at 2.4 A resolution. The structure is representative of a broad class of domains/proteins that regulate the conductance of K+ (here referred to as RCK domains) in prokaryotic K...

journal_title：Neuron

authors： Jiang Y,Pico A,Cadene M,Chait BT,MacKinnon R

更新日期：2001-03-01 00:00:00

abstract：:Examining the behavioral consequences of selective CNS neuronal activation is a powerful tool for elucidating mammalian brain function in health and disease. Newly developed genetic, pharmacological, and optical tools allow activation of neurons with exquisite spatiotemporal resolution; however, the inaccessibility to...

journal_title：Neuron

authors： Alexander GM,Rogan SC,Abbas AI,Armbruster BN,Pei Y,Allen JA,Nonneman RJ,Hartmann J,Moy SS,Nicolelis MA,McNamara JO,Roth BL

更新日期：2009-07-16 00:00:00

abstract：:Homomeric assembly of Kir5.1, an inward-rectifying K+ channel subunit, is believed to be nonfunctional, although the subunit exists abundantly in the brain. We show that HEK293T cells cotransfected with Kir5.1 and PSD-95 exhibit a Ba(2+)-sensitive inward-rectifying K+ current. Kir5.1 coexpressed with PSD-95 located on...

journal_title：Neuron

authors： Tanemoto M,Fujita A,Higashi K,Kurachi Y

更新日期：2002-04-25 00:00:00

abstract：:Uptake and transneuronal passage of wild-type and attenuated strains of a swine alpha-herpesvirus (pseudorabies [PRV]) were examined in rat visual projections. Both strains of virus infected subpopulations of retinal ganglion cells and passed transneuronally to infect retino-recipient neurons in the forebrain. However...

journal_title：Neuron

authors： Card JP,Whealy ME,Robbins AK,Moore RY,Enquist LW

更新日期：1991-06-01 00:00:00

abstract：:Agonist-induced suppression of current in voltage-gated Ca2+ channels was studied in rat sympathetic neurons. We have previously distinguished two intracellular signaling pathways used by muscarinic agonists to suppress neuronal Ca2+ current-one fast and membrane delimited, the other slow and acting via a diffusible s...

journal_title：Neuron

authors： Beech DJ,Bernheim L,Hille B

更新日期：1992-01-01 00:00:00

abstract：:Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans ...

journal_title：Neuron

authors： Ghosh DD,Sanders T,Hong S,McCurdy LY,Chase DL,Cohen N,Koelle MR,Nitabach MN

更新日期：2016-12-07 00:00:00

abstract：:Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new ho...

journal_title：Neuron

authors： Parker KE,Bruchas MR

更新日期：2018-12-19 00:00:00

abstract：:At the optic chiasm, axons from either eye meet and decide whether to cross contralaterally or turn back ipsilaterally. Here, the guidance ligand Slit and its receptor Robo control not whether axons cross (as in other midline decisions), but where the chiasm forms. Whether axons cross is instead controlled by the tran...

journal_title：Neuron

authors： Rasband K,Hardy M,Chien CB

更新日期：2003-09-11 00:00:00

abstract：:In this issue of Neuron, Ajemian et al. present a computational model of the activity of neurons in primary motor cortex (M1) during isometric movements in different postures. By modeling the output of M1 neurons in terms of their influence on muscles, they find each M1 neuron maps its output into a particular pattern...

journal_title：Neuron

authors： Pesaran B,Movshon JA

更新日期：2008-05-08 00:00:00

abstract：:Glucose-inhibited neurons orchestrate behavior and metabolism according to body energy levels, but how glucose inhibits these cells is unknown. We studied glucose inhibition of orexin/hypocretin neurons, which promote wakefulness (their loss causes narcolepsy) and also regulate metabolism and reward. Here we demonstra...

journal_title：Neuron

authors： Burdakov D,Jensen LT,Alexopoulos H,Williams RH,Fearon IM,O'Kelly I,Gerasimenko O,Fugger L,Verkhratsky A

更新日期：2006-06-01 00:00:00

abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...

journal_title：Neuron

authors： Prsa M,Galiñanes GL,Huber D

更新日期：2017-02-22 00:00:00

abstract：:Motor units comprise a pre-synaptic motor neuron and multiple post-synaptic muscle fibers. Many movement disorders disrupt motor unit contractile dynamics and the structure of sarcomeres, skeletal muscle's contractile units. Despite the motor unit's centrality to neuromuscular physiology, no extant technology can imag...

journal_title：Neuron

authors： Sanchez GN,Sinha S,Liske H,Chen X,Nguyen V,Delp SL,Schnitzer MJ

更新日期：2015-12-16 00:00:00

abstract：:Motion detection is a fundamental neural computation performed by many sensory systems. In the fly, local motion computation is thought to occur within the first two layers of the visual system, the lamina and medulla. We constructed specific genetic driver lines for each of the 12 neuron classes in the lamina. We the...

journal_title：Neuron

authors： Tuthill JC,Nern A,Holtz SL,Rubin GM,Reiser MB

更新日期：2013-07-10 00:00:00

abstract：:We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rat...

journal_title：Neuron

authors： Lamprecht R,Farb CR,LeDoux JE

更新日期：2002-11-14 00:00:00

abstract：:A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...

journal_title：Neuron

authors： Murphey RK,Godenschwege TA

更新日期：2002-09-26 00:00:00

abstract：:Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2beta, a...

journal_title：Neuron

authors： Yasuda S,Tanaka H,Sugiura H,Okamura K,Sakaguchi T,Tran U,Takemiya T,Mizoguchi A,Yagita Y,Sakurai T,De Robertis EM,Yamagata K

更新日期：2007-11-08 00:00:00

abstract：:Olfaction is a principal sensory modality in rodents, and rats quickly learn to discriminate between odors and to associate odor with reward. Here we show that such olfactory discrimination (OD) learning consists of two phases with distinct cellular mechanisms: an initial NMDAR-sensitive phase in which the animals acq...

journal_title：Neuron

authors： Quinlan EM,Lebel D,Brosh I,Barkai E

更新日期：2004-01-22 00:00:00

abstract：:Despite the fact that strong trial-to-trial correlated variability in responses has been reported in many cortical areas, recent evidence suggests that neuronal correlations are much lower than previously thought. Here, we used multicontact laminar probes to revisit the issue of correlated variability in primary visua...

journal_title：Neuron

authors： Hansen BJ,Chelaru MI,Dragoi V

更新日期：2012-11-08 00:00:00