Abstract：
:Little is known about how animals integrate multiple sensory inputs in natural environments to balance avoidance of danger with approach to things of value. Furthermore, the mechanistic link between internal physiological state and threat-reward decision making remains poorly understood. Here we confronted C. elegans worms with the decision whether to cross a hyperosmotic barrier presenting the threat of desiccation to reach a source of food odor. We identified a specific interneuron that controls this decision via top-down extrasynaptic aminergic potentiation of the primary osmosensory neurons to increase their sensitivity to the barrier. We also establish that food deprivation increases the worm's willingness to cross the dangerous barrier by suppressing this pathway. These studies reveal a potentially general neural circuit architecture for internal state control of threat-reward decision making.
journal_name
Neuronjournal_title
Neuronauthors
Ghosh DD,Sanders T,Hong S,McCurdy LY,Chase DL,Cohen N,Koelle MR,Nitabach MNdoi
10.1016/j.neuron.2016.10.030subject
Has Abstractpub_date
2016-12-07 00:00:00pages
1049-1062issue
5eissn
0896-6273issn
1097-4199pii
S0896-6273(16)30780-2journal_volume
92pub_type
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