Abstract：
:Shaker potassium channels inactivate and recover from inactivation with multiple exponential components, suggesting the presence of multiple inactivation processes. We describe two different types of inactivation in Shaker potassium channels. N-type inactivation can occur as rapidly as a few milliseconds and has been shown to involve an intracellular region at the amino-terminal acting as a blocker of the pore. C-type inactivation is independent of voltage over a range of -25 to +50 mV. It does not require intact N-type inactivation, but is partially coupled to it. The kinetics of C-type inactivation are quite different for channels with different alternatively spliced carboxy-terminal regions. We have localized the differences in C-type inactivation between the ShB and ShA variants to a single amino acid in the sixth membrane-spanning region. N- and C-type inactivation occur by distinct molecular mechanisms.
journal_name
Neuronjournal_title
Neuronauthors
Hoshi T,Zagotta WN,Aldrich RWdoi
10.1016/0896-6273(91)90367-9subject
Has Abstractpub_date
1991-10-01 00:00:00pages
547-56issue
4eissn
0896-6273issn
1097-4199pii
0896-6273(91)90367-9journal_volume
7pub_type
杂志文章相关文献
NEURON文献大全abstract：:Recent advances in connectomics have led to a synthesis of perspectives regarding the brain's functional organization that reconciles classical concepts of localized specialization with an appreciation for properties that emerge from interactions across distributed functional networks. This provides a more comprehensi...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2016.07.031
更新日期：2016-08-03 00:00:00
abstract：:The role of cellular interactions in determining the fates of two identified motoneurons in the embryonic zebrafish was investigated by transplanting individual motoneurons from labeled donor embryos to unlabeled hosts. The results suggest that although these cells normally adopt different fates, they form an equivale...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(92)90290-t
更新日期：1992-02-01 00:00:00
abstract：:The physiological role of BDNF and NT-3 in the development of the vestibular and auditory systems was investigated in mice that carry a deleted BDNF and/or NT-3 gene. BDNF was the major survival factor for vestibular ganglion neurons, and NT-3, for spiral ganglion neurons. Lack of BDNF and NT-3 did not affect ingrowth...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(95)90263-5
更新日期：1995-06-01 00:00:00
abstract：:The brain must make sense of external stimuli to generate relevant behavior. We used a combination of in vivo approaches to investigate how the cerebellum processes sensory-related information. We found that the inferior olive encodes contexts of sensory-associated external cues in a graded manner, apparent in the pre...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.03.010
更新日期：2019-05-22 00:00:00
abstract：:A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these p...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.04.003
更新日期：2007-04-19 00:00:00
abstract：:The accurate formation of synaptic vesicles (SVs) and incorporation of their protein cargo during endocytosis is critical for the maintenance of neurotransmission. During intense neuronal activity, a transient and acute accumulation of SV cargo occurs at the plasma membrane. Activity-dependent bulk endocytosis (ADBE) ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.043
更新日期：2015-12-02 00:00:00
abstract：:Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective demise of specific neuronal populations leading to impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are implicated in the biochemical ...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(01)00439-1
更新日期：2001-09-27 00:00:00
abstract：:In this issue of Neuron, Oh and Gu (2013) present a model in which intimately related embryonic nerves and blood vessels are patterned independently in response to different guidance cues from a central organizer: the whisker. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2013.09.040
更新日期：2013-10-16 00:00:00
abstract：:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2013.12.003
更新日期：2013-12-18 00:00:00
abstract：:We report a role for long-distance retrograde neurotrophin signaling in the establishment of synapses in the sympathetic nervous system. Target-derived NGF is both necessary and sufficient for formation of postsynaptic specializations on dendrites of sympathetic neurons. This, in turn, is a prerequisite for formation ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.07.018
更新日期：2010-08-12 00:00:00
abstract：:A fundamental property of neuronal circuits is the ability to adapt to altered sensory inputs. It is well established that the functional synaptic changes underlying this adaptation are reflected by structural modifications in excitatory neurons. In contrast, the degree to which structural plasticity in inhibitory neu...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2011.06.034
更新日期：2011-09-08 00:00:00
abstract：:During binocular rivalry, conflicting monocular images undergo alternating suppression. This study explores rivalry suppression by probing visual sensitivity during rivalry with various probe stimuli. When two faces engage in rivalry, sensitivity to face probes is reduced 4-fold during suppression. Rivaling global mot...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2006.10.027
更新日期：2006-12-07 00:00:00
abstract：:Neuronal activity-dependent processes are believed to mediate the formation of synaptic connections during neocortical development, but the underlying intracellular mechanisms are not known. In the visual system, altering the pattern of visually driven neuronal activity by monocular deprivation induces cortical synapt...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/s0896-6273(00)80679-0
更新日期：1999-01-01 00:00:00
abstract：:In this issue of Neuron, Tufail et al. present an underlying mechanism for microglia-mediated elimination of virally transduced cells in the central nervous system. These findings could contribute to the development of improved gene therapies for various neurological disorders by exploring why microglia destroy viable...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2017.01.025
更新日期：2017-02-08 00:00:00
abstract：:T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2014.07.036
更新日期：2014-09-03 00:00:00
abstract：:Two articles in this issue of Neuron (Eichner et al. and Clark et al.) attack the problem of explaining how neuronal hardware in Drosophila implements the Reichardt motion detector, one of the most famous computational models in neuroscience, which has proven intractable up to now. ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/j.neuron.2011.06.005
更新日期：2011-06-23 00:00:00
abstract：:We have examined the role of presynaptic residual calcium in maintaining long-term changes in synaptic efficacy observed at mossy fiber synapses between hippocampal dentate granule cells and CA3 pyramidal cells. Calcium concentrations in individual mossy fiber terminals in hippocampal slice were optically measured wit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(91)90297-d
更新日期：1991-09-01 00:00:00
abstract：:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(93)90072-y
更新日期：1993-10-01 00:00:00
abstract：:Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2019.09.045
更新日期：2020-01-08 00:00:00
abstract：:The neural basis of spatial processing in the auditory cortex has been controversial. Human fMRI studies suggest that a part of the planum temporale (PT) is involved in auditory spatial processing, but it was recently argued that this region is active only when the task requires voluntary spatial localization. If this...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2007.08.019
更新日期：2007-09-20 00:00:00
abstract：:Functional PNS regeneration requires injured axons to return to their original synaptic targets, yet the mechanisms underlying target-selective regeneration have remained elusive. Using live-cell imaging in zebrafish we find that regenerating motor axons exhibit a strong preference for their original muscle territory ...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2015.10.004
更新日期：2015-11-18 00:00:00
abstract：:The parietal lobes of nonhuman primates have been well characterized by single neuron recordings, yet clear partitioning of the human parietal lobes has not been clearly demonstrated. An elegant new fMRI study by Simon and colleagues (this issue of Neuron) suggests that parietal cortex does indeed contain dissociable ...
journal_title：Neuron
pub_type： 评论,杂志文章
doi：10.1016/s0896-6273(02)00584-6
更新日期：2002-01-31 00:00:00
abstract：:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(90)90059-o
更新日期：1990-03-01 00:00:00
abstract：:The brain has often been described, quite accurately, as one of the most complex objects in the natural world. Understanding its workings, to say nothing about intervening in them, is among the hardest problems in science. While this makes the challenge all the more enticing, in the short term, it acts to limit the im...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2016.10.044
更新日期：2016-11-02 00:00:00
abstract：:Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/s0896-6273(03)00840-7
更新日期：2004-01-08 00:00:00
abstract：:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related defic...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2010.11.030
更新日期：2010-12-22 00:00:00
abstract：:The balance between excitatory and inhibitory (E and I) synapses is thought to be critical for information processing in neural circuits. However, little is known about the spatial principles of E and I synaptic organization across the entire dendritic tree of mammalian neurons. We developed a new open-source reconstr...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2020.02.015
更新日期：2020-05-20 00:00:00
abstract：:Long-term, but not short-term, facilitation induced by 5-HT in Aplysia sensory neurons is blocked by application of inhibitors of protein synthesis or RNA synthesis during the 1.5 hr training period. These findings suggest that genes and proteins not needed for the short-term process are required for long-term facilit...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/0896-6273(89)90046-9
更新日期：1989-06-01 00:00:00
abstract：:Functional neuroimaging uses activity-dependent changes in cerebral blood flow to map brain activity, but the contributions of presynaptic and postsynaptic activity are incompletely understood, as are the underlying cellular pathways. Using intravital multiphoton microscopy, we measured presynaptic activity, postsynap...
journal_title：Neuron
pub_type： 杂志文章
doi：10.1016/j.neuron.2008.04.029
更新日期：2008-06-26 00:00:00
abstract：:Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density. Activation of Gp1 mGluRs typically occurs in response to strong activity and triggers long-term plasticity of synaptic transmission in many brain regions, including the...
journal_title：Neuron
pub_type： 杂志文章,评审
doi：10.1016/j.neuron.2010.01.016
更新日期：2010-02-25 00:00:00
