A genetic push to understand motion detection.

abstract：:Cognitive maps are encoded in the hippocampal formation and related regions and range from the spatial to the purely conceptual. Neural mechanisms that encode information into relational structures, up to an arbitrary level of abstraction, may explain such a broad range of representation. Research now indicates that s...

journal_title：Neuron

authors： Schafer M,Schiller D

更新日期：2018-10-24 00:00:00

abstract：:Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...

journal_title：Neuron

authors： Wang BS,Sarnaik R,Cang J

更新日期：2010-01-28 00:00:00

abstract：:In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like thos...

journal_title：Neuron

authors： Wright AP,Zinn K

更新日期：2009-10-29 00:00:00

abstract：:Mutations in the retinal degeneration, retinal degeneration slow(/peripherin) and rhodopsin genes cause photoreceptor degeneration in humans and mice. Although the phenotypes arising from these mutations are different, suggesting different mechanisms of pathogenesis, we present evidence that apoptosis may be the final...

journal_title：Neuron

authors： Chang GQ,Hao Y,Wong F

更新日期：1993-10-01 00:00:00

abstract：:Both acute and chronic changes in AMPA receptor (AMPAR) localization are critical for synaptic formation, maturation, and plasticity. Here I report that AMPARs are differentially sorted between recycling and degradative pathways following endocytosis. AMPAR sorting occurs in early endosomes and is regulated by synapti...

journal_title：Neuron

authors： Ehlers MD

更新日期：2000-11-01 00:00:00

abstract：:Synchronized oscillatory activity at the gamma frequency (30-70 Hz) is thought to be important for information processing in many sensory systems. Here, I used patch-clamp recordings in neuron pairs in rat olfactory bulb slices to assess the mechanisms underlying such "gamma" activity in the olfactory system. Patterne...

journal_title：Neuron

authors： Schoppa NE

更新日期：2006-01-19 00:00:00

abstract：:Backpropagating action potentials (bAPs) are an important signal for associative synaptic plasticity in many neurons, but they often fail to fully invade distal dendrites. In this issue of Neuron, Sjöström and Häusser show that distal propagation failure leads to a spatial gradient of Hebbian plasticity in neocortical...

journal_title：Neuron

authors： Bender VA,Feldman DE

更新日期：2006-07-20 00:00:00

abstract：:The differentiation of neuronal cell progenitors depends on complex interactions between intrinsic cellular programs and environmental cues. Such interactions have recently been explored using an immortalized sympathoadrenal progenitor cell line, MAH. These studies have revealed that depolarizing conditions, in combin...

journal_title：Neuron

authors： Ip NY,Boulton TG,Li Y,Verdi JM,Birren SJ,Anderson DJ,Yancopoulos GD

更新日期：1994-08-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in the low-complexity domain (LCD) of T cell-rest...

journal_title：Neuron

authors： Mackenzie IR,Nicholson AM,Sarkar M,Messing J,Purice MD,Pottier C,Annu K,Baker M,Perkerson RB,Kurti A,Matchett BJ,Mittag T,Temirov J,Hsiung GR,Krieger C,Murray ME,Kato M,Fryer JD,Petrucelli L,Zinman L,Weintraub S,

更新日期：2017-08-16 00:00:00

abstract：:Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-t...

journal_title：Neuron

authors： Prsa M,Galiñanes GL,Huber D

更新日期：2017-02-22 00:00:00

abstract：:There has been a surge of interest in how inhibitory neurons influence the output of local circuits in the brain. In this issue of Neuron, Scholl et al. (2015) provide a compelling argument for what one class of inhibitory neurons actually does. ...

journal_title：Neuron

authors： Trachtenberg JT

更新日期：2015-07-15 00:00:00

abstract：:Innate defense behaviors (IDBs) evoked by threatening sensory stimuli are essential for animal survival. Although subcortical circuits are implicated in IDBs, it remains largely unclear whether sensory cortex modulates IDBs and what the underlying neural pathways are. Here, we show that optogenetic silencing of cortic...

journal_title：Neuron

authors： Liang F,Xiong XR,Zingg B,Ji XY,Zhang LI,Tao HW

更新日期：2015-05-06 00:00:00

abstract：:Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including lear...

journal_title：Neuron

authors： Brooks ES,Greer CL,Romero-Calderón R,Serway CN,Grygoruk A,Haimovitz JM,Nguyen BT,Najibi R,Tabone CJ,de Belle JS,Krantz DE

更新日期：2011-10-20 00:00:00

abstract：:To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the brain reward system, we undertook a phenotype-driven approach using genome-wide microarray profiling of striatal transcripts from three genetic and one pharmacological mouse models of psychostimulant or dopamine supersensitivity...

journal_title：Neuron

authors： Yao WD,Gainetdinov RR,Arbuckle MI,Sotnikova TD,Cyr M,Beaulieu JM,Torres GE,Grant SG,Caron MG

更新日期：2004-02-19 00:00:00

abstract：:We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...

journal_title：Neuron

authors： Milone M,Wang HL,Ohno K,Prince R,Fukudome T,Shen XM,Brengman JM,Griggs RC,Sine SM,Engel AG

更新日期：1998-03-01 00:00:00

abstract：:Recent evidence has challenged the view that memories are made permanent by a consolidation process that happens just once and instead have suggested that memories are "re-consolidated" after reminders. The current findings of Morris et al. in this issue of Neuron suggest that reconsolidation may involve a complex int...

journal_title：Neuron

authors： Eichenbaum H

更新日期：2006-05-04 00:00:00

abstract：:A recent paper in Nature (Lim et al., 2012) describes the effects of melanocortin receptors in the nucleus accumbens. The studies connect a hypothalamic peptide system with brain reward centers and show effects on specific neuronal populations and behavioral components of mood. ...

journal_title：Neuron

authors： Land BB,DiLeone RJ

更新日期：2012-08-09 00:00:00

abstract：:In daylight, the input to the retinal circuit is provided primarily by cone photoreceptors acting as band-pass filters, but the retinal output also contains neuronal populations transmitting sustained signals. Using in vivo imaging of genetically encoded calcium reporters, we investigated the circuits that generate th...

journal_title：Neuron

authors： Rosa JM,Ruehle S,Ding H,Lagnado L

更新日期：2016-04-20 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+ transients, induced by the neurotransmitter ATP acting on purinergic receptors, both increase proliferation and stimulate ...

journal_title：Neuron

authors： Pearson RA,Dale N,Llaudet E,Mobbs P

更新日期：2005-06-02 00:00:00

abstract：:Synaptic clustering of neurotransmitter receptors is crucial for efficient signal transduction and integration in neurons. PDZ domain-containing proteins such as PSD-95/SAP90 interact with the intracellular C termini of a variety of receptors and are thought to be important in the targeting and anchoring of receptors ...

journal_title：Neuron

authors： Xia J,Zhang X,Staudinger J,Huganir RL

更新日期：1999-01-01 00:00:00

abstract：:Direct brain stimulation has diverse effects on network activity. In this issue of Neuron, Qiao et al. (2020) demonstrate a novel approach for using stimulation to characterize and modulate interactions between areas of the mood processing network. ...

journal_title：Neuron

authors： Ezzyat Y

更新日期：2020-09-09 00:00:00

abstract：:To investigate the role of the pathogenic prion protein (PrP(Sc)) in controlling susceptibility to foreign prions, two Syrian hamster (SHa) prion strains, Sc237 and DY, were transmitted to transgenic mice expressing chimeric SHa/mouse PrP genes, Tg(MH2M). First passage of SHa(Sc237) prions exhibited prolonged incubati...

journal_title：Neuron

authors： Peretz D,Williamson RA,Legname G,Matsunaga Y,Vergara J,Burton DR,DeArmond SJ,Prusiner SB,Scott MR

更新日期：2002-06-13 00:00:00

abstract：:Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampl...

journal_title：Neuron

authors： Lipton PA,Alvarez P,Eichenbaum H

更新日期：1999-02-01 00:00:00

abstract：:We show here that antisense MAP2 oligonucleotides inhibit neurite outgrowth in cultured cerebellar macroneurons. Unlike control neurons, which first extend a lamellipodial veil followed by a consolidation phase during which the cells extend minor neurites, MAP2-suppressed cells persist with lamellipodia and later beco...

journal_title：Neuron

authors： Caceres A,Mautino J,Kosik KS

更新日期：1992-10-01 00:00:00

abstract：:At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could repr...

journal_title：Neuron

authors： Norsworthy MW,Bei F,Kawaguchi R,Wang Q,Tran NM,Li Y,Brommer B,Zhang Y,Wang C,Sanes JR,Coppola G,He Z

更新日期：2017-06-21 00:00:00

abstract：:Cortical development depends upon tightly controlled cell fate and cell survival decisions that generate a functional neuronal population, but the coordination of these two processes is poorly understood. Here we show that conditional removal of a key apical complex protein, Pals1, causes premature withdrawal from the...

journal_title：Neuron

authors： Kim S,Lehtinen MK,Sessa A,Zappaterra MW,Cho SH,Gonzalez D,Boggan B,Austin CA,Wijnholds J,Gambello MJ,Malicki J,LaMantia AS,Broccoli V,Walsh CA

更新日期：2010-04-15 00:00:00

abstract：:The visual cortex represents stimuli through the activity of neuronal populations. We measured the evolution of this activity in space and time by imaging voltage-sensitive dyes in cat area V1. Contrast-reversing stimuli elicit responses that oscillate at twice the stimulus frequency, indicating that signals originate...

journal_title：Neuron

authors： Benucci A,Frazor RA,Carandini M

更新日期：2007-07-05 00:00:00

abstract：:Formation of the normal mammalian cerebral cortex requires the migration of GABAergic inhibitory interneurons from an extracortical origin, the lateral ganglionic eminence (LGE). Mechanisms guiding the migratory direction of these neurons, or other neurons in the neocortex, are not well understood. We have used an exp...

journal_title：Neuron

authors： Zhu Y,Li H,Zhou L,Wu JY,Rao Y

更新日期：1999-07-01 00:00:00

abstract：:Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same ...

journal_title：Neuron

authors： Jacob PF,Waddell S

更新日期：2020-06-17 00:00:00