Abstract:
:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified visinin antibody reacted only with a 24 kd protein in retinal cone cells. Visinin mRNA was expressed only in the retinal photoreceptor layer. The nucleotide sequence of the cDNA revealed that visinin has three E-F hand structures and is a Ca2+ binding protein. Visinin protein expressed in E. coli exhibited Ca2+ binding activity. These results suggest that visinin is a photoreceptor-specific Ca2+ binding protein and may be involved in phototransduction in the cone cells.
journal_name
Neuronjournal_title
Neuronauthors
Yamagata K,Goto K,Kuo CH,Kondo H,Miki Ndoi
10.1016/0896-6273(90)90059-osubject
Has Abstractpub_date
1990-03-01 00:00:00pages
469-76issue
3eissn
0896-6273issn
1097-4199pii
0896-6273(90)90059-Ojournal_volume
4pub_type
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