Visinin: a novel calcium binding protein expressed in retinal cone cells.

Abstract:

:Visinin is a retinal cone cell-specific protein (molecular weight 24,000, pI 5.1). To investigate its function, visinin cDNA was isolated from a chick retinal lambda gt11 cDNA library, using anti-visinin serum. The beta-galactosidase-visinin fusion protein was used for purifying epitope-selected antibody. The purified visinin antibody reacted only with a 24 kd protein in retinal cone cells. Visinin mRNA was expressed only in the retinal photoreceptor layer. The nucleotide sequence of the cDNA revealed that visinin has three E-F hand structures and is a Ca2+ binding protein. Visinin protein expressed in E. coli exhibited Ca2+ binding activity. These results suggest that visinin is a photoreceptor-specific Ca2+ binding protein and may be involved in phototransduction in the cone cells.

journal_name

Neuron

journal_title

Neuron

authors

Yamagata K,Goto K,Kuo CH,Kondo H,Miki N

doi

10.1016/0896-6273(90)90059-o

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

469-76

issue

3

eissn

0896-6273

issn

1097-4199

pii

0896-6273(90)90059-O

journal_volume

4

pub_type

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