Abstract:
:Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many years to decades. Five AD biomarkers are sufficiently validated to have been incorporated into clinical diagnostic criteria and commonly used in therapeutic trials. Current AD biomarkers fall into two categories: biomarkers of amyloid-β plaques and of tau-related neurodegeneration. Three of the five are imaging measures and two are cerebrospinal fluid analytes. AD biomarkers do not evolve in an identical manner but rather in a sequential but temporally overlapping manner. Models of the temporal evolution of AD biomarkers can take the form of plots of biomarker severity (degree of abnormality) versus time. In this Review, we discuss several time-dependent models of AD that take into consideration varying age of onset (early versus late) and the influence of aging and co-occurring brain pathologies that commonly arise in the elderly.
journal_name
Neuronjournal_title
Neuronauthors
Jack CR Jr,Holtzman DMdoi
10.1016/j.neuron.2013.12.003subject
Has Abstractpub_date
2013-12-18 00:00:00pages
1347-58issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(13)01133-1journal_volume
80pub_type
杂志文章,评审相关文献
NEURON文献大全abstract::To discover new genes involved in axon navigation, we conducted a forward genetic screen for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU. In Magellan mutant embryos, motor axons were error prone and wandered inefficiently at choice points within embryos, but paradoxic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.09.009
更新日期:2007-11-21 00:00:00
abstract::Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.009
更新日期:2014-05-07 00:00:00
abstract::Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.009
更新日期:2019-03-20 00:00:00
abstract::Fibroblastic 3T3 and endocrine RIN cells were genetically modified by infection with a recombinant retrovirus encoding the form I of human tyrosine hydroxylase (TH) and selection in tyrosine-free medium. These cells were grafted to rats unilaterally lesioned with 6-hydroxy-dopamine. Both cell types survived implantati...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90078-t
更新日期:1990-10-01 00:00:00
abstract::Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing. Each ectodomain, comprising a unique combination of three variable (Ig) domains, exhibits isoform-specific homophilic binding in vitro. Although we have proposed that the ab...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.02.029
更新日期:2012-04-26 00:00:00
abstract::Certain neurons in the mammalian brain have long been known to be joined by gap junctions, which are the most common type of electrical synapse. More recently, cloning of neuron-specific connexins, increased capability of visualizing cells within brain tissue, labeling of cell types by transgenic methods, and generati...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(04)00043-1
更新日期:2004-02-19 00:00:00
abstract::Innate defensive responses are essential for animal survival and are conserved across species. The ventral tegmental area (VTA) plays important roles in learned appetitive and aversive behaviors, but whether it plays a role in mediating or modulating innate defensive responses is currently unknown. We report that VTAG...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.05.027
更新日期:2019-08-07 00:00:00
abstract::The enteric nervous system (ENS) in vertebrates is derived mainly from vagal neural crest cells that enter the foregut and colonize the entire wall of the gastrointestinal tract. Failure to completely colonize the gut results in the absence of enteric ganglia (Hirschsprung's disease). Two signaling systems mediated by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00730-x
更新日期:2003-12-04 00:00:00
abstract::The processing of sensory information varies widely across behavioral states. However, little is known about how behavioral states modulate the intracellular activity of cortical neurons to effect changes in sensory responses. Here, we performed whole-cell recordings from neurons in upper-layer primary visual cortex o...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.08.007
更新日期:2013-10-16 00:00:00
abstract::To investigate the structural determinants underlying transport by the glutamate transporter EAAT1, we mutated each of 24 highly conserved residues (P392 to Q415) to cysteine. A majority of these substituted cysteines react with the sulfhydryl-modifying reagent MTSEA, suggesting that they reside in an aqueous environm...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80666-2
更新日期:1998-12-01 00:00:00
abstract::Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate that mGluR-LTD induces a transient, translation-dependent increase in FMRP that is rapidly degraded by the ubiquitin-proteasome pathway. Moreover, proteasome inhi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.07.005
更新日期:2006-08-17 00:00:00
abstract::Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions bet...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2008.08.020
更新日期:2008-09-25 00:00:00
abstract::Fragile X syndrome is a leading heritable cause of mental retardation that results from the loss of FMR1 gene function. A Drosophila model for Fragile X syndrome, based on the loss of dfmr1 activity, exhibits phenotypes that bear similarity to Fragile X-related symptoms. Herein, we demonstrate that treatment with meta...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.01.038
更新日期:2005-03-03 00:00:00
abstract::A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90161-j
更新日期:1993-04-01 00:00:00
abstract::The trigeminal loop in the brainstem comprises the innermost level of sensorimotor feedback in the rat vibrissa system. Anatomy suggests that this loop relays tactile information from the vibrissae to the motoneurons that control vibrissa movement. We demonstrate, using in vitro and in vivo recordings, that the trigem...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.12.042
更新日期:2005-02-03 00:00:00
abstract::The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90350-o
更新日期:1990-12-01 00:00:00
abstract::We recently applied multiplexed seqFISH to profile expressions of hundreds of genes at the single-cell level in situ (Shah et al., 2016) and provided a map of spatial heterogeneity within each subregion, reconciling previously contradictory descriptions of CA1 at lower spatial resolutions. The accompanying Matters Ari...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.05.008
更新日期:2017-05-17 00:00:00
abstract::Mouse vision is based on the parallel output of more than 30 functional types of retinal ganglion cells (RGCs). Little is known about how representations of visual information change between retina and dorsolateral geniculate nucleus (dLGN) of the thalamus, the main relay between retina and cortex. Here, we functional...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.040
更新日期:2019-04-17 00:00:00
abstract::Changes in social preference of amphibian larvae result from sustained exposure to kinship odorants. To understand the molecular and cellular mechanisms of this neuroplasticity, we investigated the effects of olfactory system activation on neurotransmitter (NT) expression in accessory olfactory bulb (AOB) interneurons...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.08.023
更新日期:2017-09-13 00:00:00
abstract::We have cloned the rat gene encoding peripherin, a neuronal-specific intermediate filament protein that is NGF-regulated. Determination of the complete sequence, including 821 nucleotides of the 5'-flanking region, allows us to make conclusions about the evolutionary origin of the peripherin gene, its homology with ot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90228-6
更新日期:1989-01-01 00:00:00
abstract::By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2016.04.008
更新日期:2016-04-20 00:00:00
abstract::During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we show that the transmembr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.05.020
更新日期:2014-07-02 00:00:00
abstract::Exocytosis and the cell-averaged cytosolic [Ca2+], [Ca2+]i, were tracked in single gonadotrophs. Cells released 100 granules/s at 1 microM = [Ca2+]i when gonadotropin-releasing hormone (GnRH) activated IP3-mediated Ca2+ release from internal stores, but only 1 granule/s when [Ca2+]i was raised uniformly to 1 microM by...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80051-9
更新日期:1997-01-01 00:00:00
abstract::Neuro-Education is a nascent discipline that seeks to blend the collective fields of neuroscience, psychology, cognitive science, and education to create a better understanding of how we learn and how this information can be used to create more effective teaching methods, curricula, and educational policy. Though stil...
journal_title:Neuron
pub_type: 历史文章,杂志文章
doi:10.1016/j.neuron.2010.08.028
更新日期:2010-09-09 00:00:00
abstract::Unequivocal proof that the activity of a localized cortical neuronal population provides sufficient basis for a specific cognitive function has rarely been obtained. We looked for such proof in monkeys trained to discriminate between two mechanical flutter stimuli applied sequentially to the fingertips. Microelectrode...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81156-3
更新日期:2000-04-01 00:00:00
abstract::The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.025
更新日期:2006-02-16 00:00:00
abstract::The tactile somatosensory pathway from whisker to cortex in rodents provides a well-defined system for exploring the link between molecular mechanisms, synaptic circuits, and behavior. The primary somatosensory cortex has an exquisite somatotopic map where each individual whisker is represented in a discrete anatomica...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2007.09.017
更新日期:2007-10-25 00:00:00
abstract::Nogo-A, a reticulon protein expressed by oligodendrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone collapse and neurite outgrowth in vitro assays, and antibody and inhibitor studies have implicated a role for Nogo in regeneration in the adult CNS in vivo. Three independent l...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00233-2
更新日期:2003-04-24 00:00:00
abstract::Learning can be characterized as the extraction of reliable predictions about stimulus occurrences from past experience. In two experiments, we investigated the interval of temporal integration of previous learning trials in different brain regions using implicit and explicit Pavlovian fear conditioning with a dynamic...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.008
更新日期:2005-07-21 00:00:00
abstract::Visual information reaches the brain by way of a fine cable, the optic nerve. The million or so axons in the optic nerve represent an information bottleneck in the visual pathway-where the fewest number of neurons convey the visual scene. It has long been thought that to make the most of the optic nerve's limited capa...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/j.neuron.2005.04.018
更新日期:2005-05-05 00:00:00