Local Ca2+ release from internal stores controls exocytosis in pituitary gonadotrophs.

abstract：:RNA transport is an important and fundamental event for local protein synthesis, especially in neurons. RNA is transported as large granules, but little is known about them. Here, we isolated a large RNase-sensitive granule (size: 1000S approximately) as a binding partner of conventional kinesin (KIF5). We identified ...

journal_title：Neuron

authors： Kanai Y,Dohmae N,Hirokawa N

更新日期：2004-08-19 00:00:00

abstract：:Mesolimbic dopamine (DA) neurons play a central role in motivation and reward processing. Although the activity of these mesolimbic DA neurons is controlled by afferent inputs, little is known about the circuits in which they are embedded. Using retrograde tracing, electrophysiology, optogenetics, and behavioral assay...

journal_title：Neuron

authors： Yang H,de Jong JW,Tak Y,Peck J,Bateup HS,Lammel S

更新日期：2018-01-17 00:00:00

abstract：:People are embedded in social interaction that shapes their brains throughout lifetime. Instead of emerging from lower-level cognitive functions, social interaction could be the default mode via which humans communicate with their environment. Should this hypothesis be true, it would have profound implications on how ...

journal_title：Neuron

authors： Hari R,Henriksson L,Malinen S,Parkkonen L

更新日期：2015-10-07 00:00:00

abstract：:Currently, there are no medications that effectively treat the core symptoms of Autism Spectrum Disorder (ASD). We recently found that the bacterial species Lactobacillus (L.) reuteri reverses social deficits in maternal high-fat-diet offspring. However, whether the effect of L. reuteri on social behavior is generaliz...

journal_title：Neuron

authors： Sgritta M,Dooling SW,Buffington SA,Momin EN,Francis MB,Britton RA,Costa-Mattioli M

更新日期：2019-01-16 00:00:00

abstract：:Pheromonal activation of the vomeronasal organ (VNO) elicits genetically preprogrammed behaviors and physiological changes in mammals. We have identified a novel gene family encoding over one hundred VNO specific receptors, the V3Rs. V3R sequences are highly similar to each other and appear distantly related to the pu...

journal_title：Neuron

authors： Pantages E,Dulac C

更新日期：2000-12-01 00:00:00

abstract：:Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity i...

journal_title：Neuron

authors： Threlfell S,Lalic T,Platt NJ,Jennings KA,Deisseroth K,Cragg SJ

更新日期：2012-07-12 00:00:00

abstract：:Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of ...

journal_title：Neuron

authors： Ménard C,Hein P,Paquin A,Savelson A,Yang XM,Lederfein D,Barnabé-Heider F,Mir AA,Sterneck E,Peterson AC,Johnson PF,Vinson C,Miller FD

更新日期：2002-11-14 00:00:00

abstract：:Cognitive theory posits association by juxtaposition or by fusion. We employed the measurement of event-related brain potentials (ERPs) to a concept fusion task in order to explore memory encoding of these two types of associations between word pairs, followed by a memory test for original pair order. Encoding process...

journal_title：Neuron

authors： Kounios J,Smith RW,Yang W,Bachman P,D'Esposito M

更新日期：2001-01-01 00:00:00

abstract：:Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mec...

journal_title：Neuron

authors： Deisseroth K,Tsien RW

更新日期：2002-04-11 00:00:00

abstract：:Although Caenorhabditis elegans has been utilized extensively to study synapse formation and function, relatively little is known about synaptic plasticity in C. elegans. We show that a brief treatment with the cholinesterase inhibitor aldicarb induces a form of presynaptic potentiation whereby ACh release at neuromus...

journal_title：Neuron

authors： Hu Z,Pym EC,Babu K,Vashlishan Murray AB,Kaplan JM

更新日期：2011-07-14 00:00:00

abstract：:We describe a reaggregated cell culture system in which retinal neuroepithelial cells from embryonic rats proliferate extensively and give rise to rod photoreceptors on the same schedule in vitro as they do in vivo. Both the proliferative potential of the embryonic neuroepithelial cells and the timing of their differe...

journal_title：Neuron

authors： Watanabe T,Raff MC

更新日期：1990-03-01 00:00:00

abstract：:L-Glutamate is regarded as the major excitatory neurotransmitter in the mammalian CNS. However, whether the released transmitter originates from a cytosolic pool or is discharged from synaptic vesicles by exocytosis (vesicle hypothesis) remains controversial. A problem with the general acceptance of the vesicle hypoth...

journal_title：Neuron

authors： Burger PM,Mehl E,Cameron PL,Maycox PR,Baumert M,Lottspeich F,De Camilli P,Jahn R

更新日期：1989-12-01 00:00:00

abstract：:Two types of ryanodine receptors, channels for Ca2+ release from intracellular stores, are known. We detected the skeletal muscle type only in cerebellum by immunoblot analysis of microsomes and partially purified proteins. The cardiac muscle type was found in all parts of the mouse brain. Immunohistochemical study sh...

journal_title：Neuron

authors： Kuwajima G,Futatsugi A,Niinobe M,Nakanishi S,Mikoshiba K

更新日期：1992-12-01 00:00:00

abstract：:Homeostatic regulation of energy balance in rodents changes dramatically during the first 3 postnatal weeks. Neuropeptide Y (NPY) and melanocortin neurons in the arcuate nucleus, a primary energy homeostatic center in adults, do not fully innervate the paraventricular nucleus (PVN) until the third postnatal week. We h...

journal_title：Neuron

authors： Melnick I,Pronchuk N,Cowley MA,Grove KL,Colmers WF

更新日期：2007-12-20 00:00:00

abstract：:beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memor...

journal_title：Neuron

authors： Thomas MJ,Moody TD,Makhinson M,O'Dell TJ

更新日期：1996-09-01 00:00:00

abstract：:Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been linked to mutations of the Hcrt system. Thus, the cause of human narc...

journal_title：Neuron

authors： Thannickal TC,Moore RY,Nienhuis R,Ramanathan L,Gulyani S,Aldrich M,Cornford M,Siegel JM

更新日期：2000-09-01 00:00:00

abstract：:The spatial distribution of large-scale functional networks on the cerebral cortex differs between individuals and is particularly variable in association networks that are responsible for higher-order cognition. However, it remains unknown how this functional topography evolves in development and supports cognition. ...

journal_title：Neuron

authors： Cui Z,Li H,Xia CH,Larsen B,Adebimpe A,Baum GL,Cieslak M,Gur RE,Gur RC,Moore TM,Oathes DJ,Alexander-Bloch AF,Raznahan A,Roalf DR,Shinohara RT,Wolf DH,Davatzikos C,Bassett DS,Fair DA,Fan Y,Satterthwaite TD

更新日期：2020-04-22 00:00:00

abstract：:The Prx gene in Schwann cells encodes L- and S-periaxin, two abundant PDZ domain proteins thought to have a role in the stabilization of myelin in the peripheral nervous system (PNS). Mice lacking a functional Prx gene assemble compact PNS myelin. However, the sheath is unstable, leading to demyelination and reflex be...

journal_title：Neuron

authors： Gillespie CS,Sherman DL,Fleetwood-Walker SM,Cottrell DF,Tait S,Garry EM,Wallace VC,Ure J,Griffiths IR,Smith A,Brophy PJ

更新日期：2000-05-01 00:00:00

abstract：:The stabilization of learned information into long-term memories requires new gene expression. CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a...

journal_title：Neuron

authors： Korzus E,Rosenfeld MG,Mayford M

更新日期：2004-06-24 00:00:00

abstract：:The release of neurotransmitter-filled vesicles after action potentials occurs with discrete time courses: submillisecond phasic release that can be desynchronized by activity followed by "delayed release" that persists for tens of milliseconds. Delayed release has a well-established role in synaptic integration, but ...

journal_title：Neuron

authors： Rudolph S,Overstreet-Wadiche L,Wadiche JI

更新日期：2011-06-09 00:00:00

abstract：:Neural ensembles oscillate across a broad range of frequencies and are transiently coupled or "bound" together when people attend to a stimulus, perceive, think, and act. This is a dynamic, self-assembling process, with parts of the brain engaging and disengaging in time. But how is it done? The theory of Coordination...

journal_title：Neuron

authors： Tognoli E,Kelso JA

更新日期：2014-01-08 00:00:00

abstract：:Live imaging studies in mice show that adult-born oligodendrocytes and myelin are remarkably stable. Neural activity enhances oligodendrocyte integration, arguing that internode addition rather than alteration represents the mechanism for any experience-dependent cortical myelination changes that might underpin learni...

journal_title：Neuron

authors： Swire M,Ffrench-Constant C

更新日期：2018-05-16 00:00:00

abstract：:Although motion-sensitive neurons in macaque middle temporal (MT) area are conventionally characterized using stimuli whose velocity remains constant for 1-3 s, many ecologically relevant stimuli change on a shorter time scale (30-300 ms). We compared neuronal responses to conventional (constant-velocity) and time-var...

journal_title：Neuron

authors： Buracas GT,Zador AM,DeWeese MR,Albright TD

更新日期：1998-05-01 00:00:00

abstract：:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...

journal_title：Neuron

authors： Soria-Gómez E,Busquets-Garcia A,Hu F,Mehidi A,Cannich A,Roux L,Louit I,Alonso L,Wiesner T,Georges F,Verrier D,Vincent P,Ferreira G,Luo M,Marsicano G

更新日期：2015-10-21 00:00:00

abstract：:After synaptic vesicles (SVs) undergo exocytosis, SV pools are replenished by recycling SVs at nerve terminals. At Drosophila neuromuscular synapses, there are two distinct SV pools (i.e., the exo/endo cycling pool (ECP), which primarily maintains synaptic transmission, and the reserve pool (RP), which participates in...

journal_title：Neuron

authors： Kuromi H,Kidokoro Y

更新日期：2002-07-18 00:00:00

abstract：:Astrocytes are complex bushy cells that serve important functions through close contacts between their processes and synapses. However, the spatial interactions and dynamics of astrocyte processes relative to synapses have proven problematic to study in adult living brain tissue. Here, we report a genetically targeted...

journal_title：Neuron

authors： Octeau JC,Chai H,Jiang R,Bonanno SL,Martin KC,Khakh BS

更新日期：2018-04-04 00:00:00

abstract：:Although numerous theoretical models implicate the prefrontal cortex (PFC) as a source of top-down control signals, empirical support is limited. In this review, we highlight direct evidence for this view of PFC function and discuss several lines of other supportive findings. Most evidence to-date is only suggestive d...

journal_title：Neuron

authors： Miller BT,D'Esposito M

更新日期：2005-11-23 00:00:00

abstract：:The field of motor pattern generation and motor control has progressed markedly in the last decade. There has been a revolutionary shift in thinking from hard-wired circuits to multifunctional networks. Yet, it is clear that we still have a long way to go before we understand how very large ensembles of neurons produc...

journal_title：Neuron

authors： Katz PS

更新日期：1996-02-01 00:00:00

abstract：:People often perceive configurations rather than the elements they comprise, a bias that may emerge because configurations often predict outcomes. But how does the brain learn to associate configurations with outcomes and how does this learning differ from learning about individual elements? We combined behavior, rein...

journal_title：Neuron

authors： Duncan K,Doll BB,Daw ND,Shohamy D

更新日期：2018-05-02 00:00:00

abstract：:Charybdotoxin (CTX) blocks high conductance Ca(2+)-activated K+ channels by binding to a receptor site in the externally facing "mouth." Toxin bound to the channel can be destabilized from its site by K+ entering the channel from the opposite, internal, solution. By analyzing point mutants of CTX expressed in E. coli,...

journal_title：Neuron

authors： Park CS,Miller C

更新日期：1992-08-01 00:00:00