Abstract:
:Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that cannabinoid type 1 receptors (CB1R), key regulators of aversive responses, are present at presynaptic terminals of MHb neurons in the IPN. Conditional deletion of CB1R from MHb neurons reduces fear-conditioned freezing and abolishes conditioned odor aversion in mice, without affecting neutral or appetitively motivated memories. Interestingly, local inhibition of nicotinic, but not glutamatergic receptors in the target region IPN before retrieval, rescues these phenotypes. Finally, optogenetic electrophysiological recordings of MHb-to-IPN circuitry revealed that blockade of CB1R specifically enhances cholinergic, but not glutamatergic, neurotransmission. Thus, presynaptic CB1R control expression of aversive memories by selectively modulating cholinergic transmission at MHb synapses in the IPN.
journal_name
Neuronjournal_title
Neuronauthors
Soria-Gómez E,Busquets-Garcia A,Hu F,Mehidi A,Cannich A,Roux L,Louit I,Alonso L,Wiesner T,Georges F,Verrier D,Vincent P,Ferreira G,Luo M,Marsicano Gdoi
10.1016/j.neuron.2015.08.035subject
Has Abstractpub_date
2015-10-21 00:00:00pages
306-13issue
2eissn
0896-6273issn
1097-4199pii
S0896-6273(15)00729-1journal_volume
88pub_type
杂志文章相关文献
NEURON文献大全abstract::Olfaction is a vitally important sense for all animals. There are striking similarities between species in the organization of the olfactory pathway, from the nature of the odorant receptor proteins, to perireceptor processes, to the organization of the olfactory CNS, through odor-guided behavior and memory. These com...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2005.10.022
更新日期:2005-11-03 00:00:00
abstract::In this issue of Neuron, Katsuki and colleagues show that cell-autonomous mechanisms divide Drosophila axons into proximal and distal compartments. Axon guidance receptors selectively localize to one compartment. A diffusion barrier exists near the compartment boundary, suggesting that it may have properties like thos...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2009.10.011
更新日期:2009-10-29 00:00:00
abstract::Vaccinia virus can be used to infect cells in the CNS of frogs, Xenopus laevis, and Rana pipiens, both in vivo and in vitro. In vivo infections were accomplished by injection of viral solution into the tectal ventricle of stage 40-48 tadpoles or by local injections into distinct neural regions. Infections with high ti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(95)90211-2
更新日期:1995-04-01 00:00:00
abstract::To assess the necessary parameters for the growth of axons within the adult rat CNS, we have used intracerebral grafts of primary fibroblasts genetically engineered to express nerve growth factor (NGF). Following the implantation of NGF-producing primary fibroblasts within the striatum, cholinergic axons arising from ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(91)90346-2
更新日期:1991-12-01 00:00:00
abstract::We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a redu...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.06.032
更新日期:2005-08-04 00:00:00
abstract::Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.06.013
更新日期:2004-07-22 00:00:00
abstract::Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connecti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.09.045
更新日期:2020-01-08 00:00:00
abstract::Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new ho...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2018.11.045
更新日期:2018-12-19 00:00:00
abstract::The visual perception of words is known to activate the auditory representation of their spoken forms automatically. We examined the neural mechanism for this phonological activation using transcranial magnetic stimulation (TMS) with a masked priming paradigm. The stimulation sites (left superior temporal gyrus [L-STG...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.030
更新日期:2006-11-09 00:00:00
abstract::GABAergic, somatostatin-containing bitufted interneurons in layer 2/3 of rat neocortex are excited via glutamatergic excitatory postsynaptic potentials (EPSPs) by pyramidal neurons located in the same cortical layer. Pair recordings showed that short bursts of backpropagating dendritic action potentials (APs) reduced ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)81044-2
更新日期:1999-12-01 00:00:00
abstract::We describe the isolation and characterization of a cDNA encoding the alpha subunit of a new voltage-sensitive sodium channel, microI, from rat skeletal muscle. The 1840 amino acid microI peptide is homologous to alpha subunits from rat brain, but, like the protein from eel electroplax, lacks an extended (approximatel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(89)90113-x
更新日期:1989-07-01 00:00:00
abstract::The blood-brain barrier (BBB) poses a major challenge for developing effective antibody therapies for neurological diseases. Using transcriptomic and proteomic profiling, we searched for proteins in mouse brain endothelial cells (BECs) that could potentially be exploited to transport antibodies across the BBB. Due to ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.11.024
更新日期:2016-01-06 00:00:00
abstract::Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.06.050
更新日期:2017-08-02 00:00:00
abstract::We recently proposed that ciliary neurotrophic factor (CNTF) shares two receptor components with a generally acting cytokine, leukemia inhibitory factor (LIF), but that CNTF also requires a third receptor component (CNTFR alpha) that is mostly restricted to the nervous system in its expression. Here we demonstrate tha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90245-m
更新日期:1993-01-01 00:00:00
abstract::The visual cortex has the capacity for experience-dependent change, or cortical plasticity, that is retained throughout life. Plasticity is invoked for encoding information during perceptual learning, by internally representing the regularities of the visual environment, which is useful for facilitating intermediate-l...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2012.06.030
更新日期:2012-07-26 00:00:00
abstract::In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singula...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)00223-9
更新日期:2001-02-01 00:00:00
abstract::Lipids are prominent components of the nervous system. Here we performed a large-scale mass spectrometry-based analysis of the lipid composition of three brain regions as well as kidney and skeletal muscle of humans, chimpanzees, rhesus macaques, and mice. The human brain shows the most distinct lipid composition: 76%...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.01.003
更新日期:2015-02-18 00:00:00
abstract::Induced CREB activity is a hallmark of long-term memory, but the full repertoire of CREB transcriptional targets required specifically for memory is not known in any system. To obtain a more complete picture of the mechanisms involved in memory, we combined memory training with genome-wide transcriptional analysis of ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.12.029
更新日期:2015-01-21 00:00:00
abstract::T-type calcium channels are essential contributors to the transmission of nociceptive signals in the primary afferent pain pathway. Here, we show that T-type calcium channels are ubiquitinated by WWP1, a plasma-membrane-associated ubiquitin ligase that binds to the intracellular domain III-IV linker region of the Cav3...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.07.036
更新日期:2014-09-03 00:00:00
abstract::A series of recent papers highlight a prominent role for ubiquitin in the formation and function of neural circuits. These new results focus attention on the molecular remodeling that occurs at various decision points in the life of growth cones and synapses. ...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(02)00943-1
更新日期:2002-09-26 00:00:00
abstract::Astrocytes invade the developing retina from the optic nerve head, over the axons of retinal ganglion cells (RGCs). RGCs express the platelet-derived growth factor A-chain (PDGF-A) and retinal astrocytes the PDGF alpha-receptor (PDGFR alpha), suggesting that PDGF mediates a paracrine interaction between these cells. T...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80244-5
更新日期:1996-12-01 00:00:00
abstract::Cytokines are pleotrophic proteins that coordinate the host response to infection as well as mediate normal, ongoing signaling between cells of nonimmune tissues, including the nervous system. As a consequence of this dual role, cytokines induced in response to maternal infection or prenatal hypoxia can profoundly imp...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2009.09.002
更新日期:2009-10-15 00:00:00
abstract::The selection and timing of actions are subject to determinate influences such as sensory cues and internal state as well as to effectively stochastic variability. Although stochastic choice mechanisms are assumed by many theoretical models, their origin and mechanisms remain poorly understood. Here we investigated th...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.04.040
更新日期:2017-05-17 00:00:00
abstract::Neurons adapt their synaptic responses to the activity of the underlying network. In this issue of Neuron, Thiagarajan and colleagues report on specific subcellular mechanisms of homeostasis after prolonged neuronal inactivity. The results have important implications not only for neuronal homeostasis but also for furt...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2005.08.018
更新日期:2005-09-01 00:00:00
abstract::The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for proper polarization of developing neurons. We show that knockout of Wwp1 and...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2018.10.008
更新日期:2018-12-05 00:00:00
abstract::We have purified and characterized a factor, from the conditioned medium of neural stem cell cultures, which is required for fibroblast growth factor 2's (FGF-2) mitogenic activity on neural stem cells. This autocrine/paracrine cofactor is a glycosylated form of cystatin C (CCg), whose N-glycosylation is required for ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)00119-7
更新日期:2000-11-01 00:00:00
abstract::Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial....
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00126-0
更新日期:2003-03-27 00:00:00
abstract::Opiate analgesia, tolerance, and addiction are mediated by drug-induced activation of the mu opioid receptor. A fundamental question in addiction biology is why exogenous opiate drugs have a high liability for inducing tolerance and addiction while native ligands do not. Studies indicate that highly addictive opiate d...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(01)80032-5
更新日期:1999-08-01 00:00:00
abstract::Retrograde signals from postsynaptic targets are critical during development and plasticity of synaptic connections. These signals serve to adjust the activity of presynaptic cells according to postsynaptic cell outputs and to maintain synaptic function within a dynamic range. Despite their importance, the mechanisms ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2013.01.013
更新日期:2013-03-20 00:00:00
abstract::The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.07.008
更新日期:2008-09-11 00:00:00