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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease.

Abstract：

:Studies on postmortem brains from Parkinson's patients reveal elevated iron in the substantia nigra (SN). Selective cell death in this brain region is associated with oxidative stress, which may be exacerbated by the presence of excess iron. Whether iron plays a causative role in cell death, however, is controversial. Here, we explore the effects of iron chelation via either transgenic expression of the iron binding protein ferritin or oral administration of the bioavailable metal chelator clioquinol (CQ) on susceptibility to the Parkinson's-inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrapyridine (MPTP). Reduction in reactive iron by either genetic or pharmacological means was found to be well tolerated in animals in our studies and to result in protection against the toxin, suggesting that iron chelation may be an effective therapy for prevention and treatment of the disease.

journal_name

Neuron

journal_title

Neuron

authors

Kaur D,Yantiri F,Rajagopalan S,Kumar J,Mo JQ,Boonplueang R,Viswanath V,Jacobs R,Yang L,Beal MF,DiMonte D,Volitaskis I,Ellerby L,Cherny RA,Bush AI,Andersen JK

doi

10.1016/s0896-6273(03)00126-0

subject

Has Abstract

pub_date

2003-03-27 00:00:00

pages

899-909

issue

6

eissn

0896-6273

issn

1097-4199

pii

S0896627303001260

journal_volume

37

pub_type

杂志文章

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