Abstract:
:N-type calcium channels play a dominant role in controlling synaptic transmission in many peripheral neurons. Transmitter release from mammalian central nerve terminals, however, is relatively resistant to the N channel antagonist omega-conotoxin GVIA. We studied the sensitivity of glutamatergic synaptic transmission in rat hippocampal slices to omega-conotoxin and to omega-Aga-IVA, a P channel antagonist. Both toxins reduced the amplitude of excitatory postsynaptic potentials in CA1 pyramidal neurons, but omega-Aga-IVA was the more rapid and efficacious. These results were corroborated by biochemical studies measuring subsecond, calcium-dependent [3H]glutamate release from hippocampal synaptosomes. Thus, at least two calcium channel types trigger glutamate release from hippocampal neurons, but P-type plays a more prominent role. Eliminating synaptic transmission in the CNS, therefore, may require inhibiting more than a single calcium channel type.
journal_name
Neuronjournal_title
Neuronauthors
Luebke JI,Dunlap K,Turner TJdoi
10.1016/0896-6273(93)90119-csubject
Has Abstractpub_date
1993-11-01 00:00:00pages
895-902issue
5eissn
0896-6273issn
1097-4199pii
0896-6273(93)90119-Cjournal_volume
11pub_type
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