Abstract:
:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predicted amphipathic alpha helix typical of the lipid-binding domain in apolipoproteins. We show this protein, which we call synelfin, to be the homolog of the human non-A beta component (and its precursor) recently purified from Alzheimer's disease amyloid. We suggest this highly conserved protein may serve a novel function critical to the regulation of vertebrate neural plasticity.
journal_name
Neuronjournal_title
Neuronauthors
George JM,Jin H,Woods WS,Clayton DFdoi
10.1016/0896-6273(95)90040-3subject
Has Abstractpub_date
1995-08-01 00:00:00pages
361-72issue
2eissn
0896-6273issn
1097-4199pii
0896-6273(95)90040-3journal_volume
15pub_type
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