Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

Abstract:

:A male zebra finch learns a song by listening to a tutor, but song learning is normally restricted to a critical period in juvenile development. Here we identify an RNA whose expression in the song control circuit is altered during this critical period. The RNA encodes a soluble presynaptic protein that forms a predicted amphipathic alpha helix typical of the lipid-binding domain in apolipoproteins. We show this protein, which we call synelfin, to be the homolog of the human non-A beta component (and its precursor) recently purified from Alzheimer's disease amyloid. We suggest this highly conserved protein may serve a novel function critical to the regulation of vertebrate neural plasticity.

journal_name

Neuron

journal_title

Neuron

authors

George JM,Jin H,Woods WS,Clayton DF

doi

10.1016/0896-6273(95)90040-3

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

361-72

issue

2

eissn

0896-6273

issn

1097-4199

pii

0896-6273(95)90040-3

journal_volume

15

pub_type

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