Abstract：
:Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function. A yeast two-hybrid analysis using the coiled-coil domain of neurabin revealed an interaction with Lfc, a Rho GEF. Lfc was highly expressed in brain, where it interacted with either neurabin or spinophilin. In neurons, Lfc was largely found in the shaft of dendrites in association with microtubules but translocated to spines upon neuronal stimulation. Moreover, expression of Lfc resulted in reduction in spine length and size. Both the translocation and the effect on spine morphology depended on the coiled-coil domain of Lfc. Coexpression of neurabin or spinophilin with Lfc resulted in their clustering together with F-actin, a process that depended on Rho activity. Thus, interaction between Lfc and neurabin/spinophilin selectively regulates Rho-dependent organization of F-actin in spines and is a link between the microtubule and F-actin cytoskeletons in dendrites.
journal_name
Neuronjournal_title
Neuronauthors
Ryan XP,Alldritt J,Svenningsson P,Allen PB,Wu GY,Nairn AC,Greengard Pdoi
10.1016/j.neuron.2005.05.013subject
Has Abstractpub_date
2005-07-07 00:00:00pages
85-100issue
1eissn
0896-6273issn
1097-4199pii
S0896-6273(05)00409-5journal_volume
47pub_type
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