Abstract:
:Retinal bipolar cells are essential to the transmission of light information. Although bipolar cell dysfunction can result in blindness, little is known about the factors required for bipolar cell development and functional maturation. The basic helix-loop-helix (bHLH) transcription factor Bhlhb4 was found to be expressed in rod bipolar cells (RB). Electroretinograms (ERGs) in the adult Bhlhb4 knockout (Bhlhb4(-/-)) showed that the loss of Bhlhb4 resulted in disrupted rod signaling and profound retinal dysfunction resembling human congenital stationary night blindness (CSNB), characterized by the loss of the scotopic ERG b-wave. A depletion of inner nuclear layer (INL) cells in the adult Bhlhb4 knockout has been ascribed to the abolishment of the RB cell population during postnatal development. Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation.
journal_name
Neuronjournal_title
Neuronauthors
Bramblett DE,Pennesi ME,Wu SM,Tsai MJdoi
10.1016/j.neuron.2004.08.032subject
Has Abstractpub_date
2004-09-16 00:00:00pages
779-93issue
6eissn
0896-6273issn
1097-4199pii
S0896627304005410journal_volume
43pub_type
杂志文章相关文献
NEURON文献大全abstract::In this issue of Neuron, Moehle et al. (2017) demonstrate that presynaptic muscarinic receptors counteract the effects of dopamine in an output nucleus of the basal ganglia. They provide intracellular, anatomical, and network-level mechanisms for this cholinergic-dopaminergic interplay. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2017.12.014
更新日期:2017-12-20 00:00:00
abstract::The serotonin system powerfully modulates physiology and behavior in health and disease, yet the circuit mechanisms underlying serotonin neuron activity are poorly understood. The major source of forebrain serotonergic innervation is from the dorsal raphe nucleus (DR), which contains both serotonin and GABA neurons. U...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.06.024
更新日期:2014-08-06 00:00:00
abstract::Recent results implicating cholesterol metabolism in the pathophysiology of Alzheimer's disease (AD) bring cholesterol to the forefront of AD research. Research from genetics, epidemiology, and cell biology all converge, suggesting that cholesterol plays a central role in the biology of amyloid precursor protein and t...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(03)00840-7
更新日期:2004-01-08 00:00:00
abstract::Perceptual learning is a lifelong process. We begin by encoding information about the basic structure of the natural world and continue to assimilate information about specific patterns with which we become familiar. The specificity of the learning suggests that all areas of the cerebral cortex are plastic and can rep...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/s0896-6273(01)00424-x
更新日期:2001-09-13 00:00:00
abstract::During binocular rivalry, conflicting monocular images undergo alternating suppression. This study explores rivalry suppression by probing visual sensitivity during rivalry with various probe stimuli. When two faces engage in rivalry, sensitivity to face probes is reduced 4-fold during suppression. Rivaling global mot...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.10.027
更新日期:2006-12-07 00:00:00
abstract::Delineating the molecular basis of synapse development is crucial for understanding brain function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse-promoting activity of candidate molecules. Here, we performed an unbiased expression screen for synaptogenic proteins in the coculture ass...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.01.017
更新日期:2009-03-12 00:00:00
abstract::Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2008.02.008
更新日期:2008-04-24 00:00:00
abstract::It is a commonly held view that numbers are represented in an abstract way in both parietal lobes. This view is based on failures to find differences between various notational representations. Here we show that by using relatively smaller voxels together with an adaptation paradigm and analyzing subjects on an indivi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.12.025
更新日期:2007-01-18 00:00:00
abstract::A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that c...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2011.02.017
更新日期:2011-02-24 00:00:00
abstract::In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP)...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(03)00465-3
更新日期:2003-08-28 00:00:00
abstract::Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.01.002
更新日期:2010-01-28 00:00:00
abstract::Embryonic retinal ganglion cell (RGC) axons must extend toward and grow through the optic disc to exit the eye into the optic nerve. In the embryonic mouse eye, we found that immunoreactivity for the axon guidance molecule netrin-1 was specifically on neuroepithelial cells at the disk surrounding exiting RGC axons, an...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80373-6
更新日期:1997-09-01 00:00:00
abstract::The ability to remember emotional events is crucial for adapting to biologically and socially significant situations. Little is known, however, about the nature of the neural interactions supporting the integration of mnemonic and emotional information. Using fMRI and dynamic models of effective connectivity, we exami...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.12.025
更新日期:2006-02-16 00:00:00
abstract::Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chime...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90079-7
更新日期:1988-06-01 00:00:00
abstract::Abnormal visual input during development has dramatic effects on the visual system. How does the adult visual system respond when input is corrected? MM lost his left eye and became blind in the right due to corneal damage at the age of 3. At age 46, MM regained his retinal image, but his visual abilities, even seven ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2009.12.006
更新日期:2010-01-14 00:00:00
abstract::The sympathetic innervation of rat sweat glands undergoes a target-induced switch from a noradrenergic to a cholinergic and peptidergic phenotype during development. Treatment of cultured sympathetic neurons with sweat gland extracts mimics many of the changes seen in vivo. Extracts induce choline acetyltransferase ac...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90350-o
更新日期:1990-12-01 00:00:00
abstract::The brain mechanisms underlying visual object categorization remain unclear. In this issue of Neuron, Minamimoto and colleagues introduce a novel task that associates each category with a different incentive value, and they demonstrate that it can be learned within a single session even after ablation of the lateral p...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2010.05.012
更新日期:2010-05-27 00:00:00
abstract::Expression of rat TrkA in Xenopus spinal neurons confers responsiveness of these neurons to nerve growth factor (NGF) in assays of neuronal survival and growth cone chemotropism. Mutational analysis indicates that coactivation of phospholipase C-gamma (PLC-gamma) and phosphoinositide 3-kinase (PI3-kinase) by specific ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80760-6
更新日期:1999-05-01 00:00:00
abstract::Leukemia inhibitory factor (LIF) is a cytokine that affects the survival and differentiation of certain neuronal populations in vitro. To identify LIF-responsive neurons in the adult rat, we have demonstrated retrograde axonal transport of 125I-LIF to sensory and motor neurons. The accumulation of 125I-LIF by both cel...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90163-5
更新日期:1994-01-01 00:00:00
abstract::Adolescence is often described as a period of heightened reactivity to emotions paired with reduced regulatory capacities, a combination suggested to contribute to risk-taking and susceptibility to peer influence during puberty. However, no longitudinal research has definitively linked these behavioral changes to unde...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.02.019
更新日期:2011-03-10 00:00:00
abstract::Primary nociceptors relay painful touch information from the periphery to the spinal cord. Although it is established that signals generated by receptor tyrosine kinases TrkA and Ret coordinate the development of distinct nociceptive circuits, mechanisms modulating TrkA or Ret pathways in developing nociceptors are un...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.04.009
更新日期:2014-05-07 00:00:00
abstract::Dopamine (DA) transmission mediates numerous aspects of behavior. Although DA release is strongly linked to firing of DA neurons, recent developments indicate the importance of presynaptic modulation at striatal dopaminergic terminals. The endocannabinoid (eCB) system regulates DA release and is a canonical gatekeeper...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2017.11.012
更新日期:2017-12-06 00:00:00
abstract::In this issue of Neuron, Holz et al. (2019) show that the synaptic protein Homer1a switches mGluR5 signaling to increase AMPA receptor activity for the rapid antidepressant actions of sleep deprivation. ...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2019.10.003
更新日期:2019-10-23 00:00:00
abstract::Basolateral amygdala and orbitofrontal cortex are implicated in cue-outcome learning. In this issue of Neuron, Schoenbaum et al. show that, following basolateral amygdala lesions, cue-selective neurons in orbitofrontal cortex are more sensory driven and less sensitive to the motivational value of an outcome, suggestin...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00525-7
更新日期:2003-08-28 00:00:00
abstract::We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)01128-5
更新日期:2003-01-09 00:00:00
abstract::A circadian clock regulates a number of diverse physiological functions in the vertebrate eye. In this study, we show that mRNA for the red-sensitive cone pigment, iodopsin, fluctuates with a circadian rhythm in chicken retina. Transcript levels increase in the late afternoon just prior to the time of cone disc sheddi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(93)90161-j
更新日期:1993-04-01 00:00:00
abstract::Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presy...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.09.003
更新日期:2006-09-21 00:00:00
abstract::Expression of aversive memories is key for survival, but the underlying brain mechanisms are not fully understood. Medial habenular (MHb) axons corelease glutamate and acetylcholine onto target postsynaptic interpeduncular (IPN) neurons, but their role in aversive memories has not been addressed so far. We found that ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.08.035
更新日期:2015-10-21 00:00:00
abstract::Development of neuronal circuits is controlled by evolutionarily conserved axon guidance molecules, including Slits, the repulsive ligands for roundabout (Robo) receptors, and Netrin-1, which mediates attraction through the DCC receptor. We discovered that the Robo3 receptor fundamentally changed its mechanism of acti...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.11.004
更新日期:2014-12-17 00:00:00
abstract::We review the central tenets and neuroanatomical basis of the global neuronal workspace (GNW) hypothesis, which attempts to account for the main scientific observations regarding the elementary mechanisms of conscious processing in the human brain. The GNW hypothesis proposes that, in the conscious state, a non-linear...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.01.026
更新日期:2020-03-04 00:00:00