Abstract:
:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP) of intrinsic hippocampal pathways abolished existing place fields, created new place fields, and rearranged the temporal relationship within the affected population. The effect of LTP on neuron discharge was rate and context dependent. The LTP-induced "remapping" occurred without affecting the global firing rate of the network. The findings support the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks.
journal_name
Neuronjournal_title
Neuronauthors
Dragoi G,Harris KD,Buzsáki Gdoi
10.1016/s0896-6273(03)00465-3subject
Has Abstractpub_date
2003-08-28 00:00:00pages
843-53issue
5eissn
0896-6273issn
1097-4199pii
S0896627303004653journal_volume
39pub_type
杂志文章相关文献
NEURON文献大全abstract::In situ hybridization histochemistry reveals localized expression of the nicotinic acetylcholine receptor (nAChR) alpha 2 subunit mRNA restricted to the lateral spiriform nucleus (SpL) of the chick diencephalon. The alpha 2 nAChR transcripts are not detected in immature SpL neurons at 4.5-5 days of embryonic developme...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90032-b
更新日期:1990-07-01 00:00:00
abstract::The molecular basis of the selective death of motor neurons in amyotrophic lateral sclerosis (ALS) has been an enigma since its description by Charcot in 1869. In this issue of Neuron, demonstrate a motor neuron-specific death pathway which involves Fas and NO. Remarkably, motor neurons from mice carrying ALS-linked m...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(02)00910-8
更新日期:2002-09-12 00:00:00
abstract::Action potentials initiate in the axon initial segment (AIS), a specialized compartment enriched with Na(+) and K(+) channels. Recently, we found that T- and R-type Ca(2+) channels are concentrated in the AIS, where they contribute to local subthreshold membrane depolarization and thereby influence action potential in...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.09.026
更新日期:2010-11-04 00:00:00
abstract::RNA binding proteins are critical to the maintenance of the transcriptome via controlled regulation of RNA processing and transport. Alterations of these proteins impact multiple steps of the RNA life cycle resulting in various molecular phenotypes such as aberrant RNA splicing, transport, and stability. Disruption of...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2019.03.014
更新日期:2019-04-17 00:00:00
abstract::We have studied the subcellular distribution of the alpha 1 and alpha 2 subunits of the dihydropyridine (DHP) receptor and ankyrin in rat skeletal muscle with immunofluorescence and immunogold labeling techniques. All three proteins were concentrated in the triad junction formed between the T-tubules and sarcoplasmic ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(90)90170-k
更新日期:1990-09-01 00:00:00
abstract::Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and expli...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.08.024
更新日期:2006-11-09 00:00:00
abstract::The precise relationship between functional and structural connectivity in the brain is not well understood. Research in this area has, so far, mostly remained descriptive. In this issue of Neuron, Mišić et al. (2015) forge a promising new direction by modeling the propagation of information as it relates to spatially...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2015.06.006
更新日期:2015-06-17 00:00:00
abstract::Intracortical somatosensory interfaces have now entered the clinical domain. Darie et al. explore the implications of research published in Science Translational Medicine by Flesher et al. (2016), discuss how to design such a system given current technology, and question how to effectively communicate with users about...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2017.02.008
更新日期:2017-02-22 00:00:00
abstract::Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly ways based on new findings regarding the neurobiological underpinnings of addictions that also assimila...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2011.02.009
更新日期:2011-02-24 00:00:00
abstract::Embryonic mouse neural tubes produce a variety of terminally differentiated cells in vitro, mostly neurons and glia. We report here that some of these cells differentiate into skeletal muscle cells. The possibility of mesoderm contamination was ruled out as follows. First, Dil+ muscle cells were present in cultures fr...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(94)90248-8
更新日期:1994-10-01 00:00:00
abstract::Recent work has suggested a link between h channels and epilepsy. In this issue of Neuron, Shah et al. demonstrate that a robust, postseizure decrease in h channels during a critical phase of epileptogenesis mechanistically underlies dendritic hyperexcitability in entorhinal-hippocampal pyramidal cells. ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2004.10.018
更新日期:2004-10-28 00:00:00
abstract::Brain nicotinic acetylcholine receptors (nAChRs) are made up of protein subunits that differ from those constituting muscle nAChRs. To characterize the physiological properties of one class of avian brain nicotinic receptor, we injected the nuclei of Xenopus oocytes with full-length cDNAs for the ligand binding (alpha...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/0896-6273(88)90132-8
更新日期:1988-11-01 00:00:00
abstract::How does a visual search goal modulate the activity of neurons encoding different visual features (e.g., color, direction of motion)? Previous research suggests that goal-driven attention enhances the gain of neurons representing the target's visual features. Here, we present mathematical and behavioral evidence that ...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2007.01.018
更新日期:2007-02-15 00:00:00
abstract::We describe the genetic and kinetic defects in a congenital myasthenic syndrome caused by heteroallelic mutations of the acetylcholine receptor (AChR) epsilon subunit gene. The mutations are an in-frame duplication of six residues in the long cytoplasmic loop (epsilon1254ins18) and a cysteine-loop null mutation (epsil...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80996-4
更新日期:1998-03-01 00:00:00
abstract::Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient nuclear accumulation of HDAC5 in rodent striatum. We show that cAMP-stimulated nuclear import of...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2011.10.032
更新日期:2012-01-12 00:00:00
abstract::Memory abilities differ greatly across individuals. To explore a source of these differences, we characterized the varied strategies people adopt during unconstrained encoding. Participants intentionally encoded object pairs during functional MRI. Principal components analysis applied to a strategy questionnaire revea...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.06.006
更新日期:2006-07-20 00:00:00
abstract::Diverse computations in the neocortex are aided by specialized GABAergic interneurons (INs), which selectively target other INs. However, much less is known about how these canonical disinhibitory circuit motifs contribute to network operations supporting spatial navigation and learning in the hippocampus. Using chron...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2019.01.009
更新日期:2019-03-20 00:00:00
abstract::Elevation of cAMP can overcome myelin inhibitors to encourage regeneration of the CNS. We show that a consequence of elevated cAMP is the synthesis of polyamines, resulting from an up-regulation of Arginase I, a key enzyme in their synthesis. Inhibiting polyamine synthesis blocks the cAMP effect on regeneration. Eithe...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(02)00826-7
更新日期:2002-08-15 00:00:00
abstract::Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)]. Here we demonstrate that relative hypoxia enhances S-nitrosylation of NMDARs by a unique me...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2006.11.023
更新日期:2007-01-04 00:00:00
abstract::Application of Clostridium difficile toxin B, an inhibitor of the Rho family of GTPases, at the Aplysia sensory to motor neuron synapse blocks long-term facilitation and the associated growth of new sensory neuron varicosities induced by repeated pulses of serotonin (5-HT). We have isolated cDNAs encoding Aplysia Rho,...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2005.01.044
更新日期:2005-03-24 00:00:00
abstract::We have made little recent progress developing effective new treatments for neuropsychiatric and neurodevelopmental disorders. Novel molecular mechanisms have been identified, but have not translated into the clinic. We suggest an alternative: combinations of treatments targeting different aspects of final common path...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2014.10.006
更新日期:2014-11-05 00:00:00
abstract::The ability of perisynaptic glial cells to modulate transmitter release and synaptic depression was studied at the frog neuromuscular junction (nmj). Injection of GTPgammaS in perisynaptic Schwann cells (PSCs), glial cells at this synapse, induced a reduction in the amplitude of nerve-evoked synaptic responses but had...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80600-5
更新日期:1998-10-01 00:00:00
abstract::The embryonic nervous system is refined over the course of development as a result of the twin processes of naturally occurring cell death and selective axon pruning. Recent studies provide new insights into the molecular events that underlie axon pruning and underscore the diversity of refinement processes employed b...
journal_title:Neuron
pub_type: 评论,杂志文章,评审
doi:10.1016/s0896-6273(03)00364-7
更新日期:2003-06-19 00:00:00
abstract::Understanding the neural basis of adaptation (repetition suppression) is critical for interpreting fMRI-adaptation experiments. Sawamura and colleagues provide a critical stepping-stone by elucidating the relation between neural adaptation and response selectivity. They find some cross-adaptation by two different stim...
journal_title:Neuron
pub_type: 评论,杂志文章
doi:10.1016/j.neuron.2006.01.004
更新日期:2006-01-19 00:00:00
abstract::The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excita...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/s0896-6273(00)80879-x
更新日期:2000-01-01 00:00:00
abstract::Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases (RPTPs) organize synapses through a network of postsynaptic ligands. We show that leucine-rich-repeat transmembrane neuronal proteins (LRRTMs) differentially engage the protein domains of Nrx but require its heparan sulfate (HS) modi...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2020.01.003
更新日期:2020-04-08 00:00:00
abstract::Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first combined with modernized light-sheet microscopy a decade ago, the performance of both tec...
journal_title:Neuron
pub_type: 杂志文章,评审
doi:10.1016/j.neuron.2020.03.004
更新日期:2020-05-06 00:00:00
abstract::Miniature synaptic currents have long been known to represent random transmitter release under resting conditions, but much remains to be learned about their nature and function in central synapses. In this work, we describe a new class of miniature currents ("preminis") that arise by the autocrine activation of axona...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.03.030
更新日期:2010-04-29 00:00:00
abstract::Changes of ocular dominance in the visual cortex can be induced by visual manipulations during a critical period in early life. However, the role of critical period plasticity in normal development is unknown. Here we show that at the onset of this time window, the preferred orientations of individual cortical cells i...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2010.01.002
更新日期:2010-01-28 00:00:00
abstract::Accurate motion detection requires neural circuitry that compensates for global visual field motion. Select subtypes of retinal ganglion cells perceive image motion and connect to the accessory optic system (AOS) in the brain, which generates compensatory eye movements that stabilize images during slow visual field mo...
journal_title:Neuron
pub_type: 杂志文章
doi:10.1016/j.neuron.2015.03.064
更新日期:2015-05-20 00:00:00