Place representation within hippocampal networks is modified by long-term potentiation.

Abstract:

:In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP) of intrinsic hippocampal pathways abolished existing place fields, created new place fields, and rearranged the temporal relationship within the affected population. The effect of LTP on neuron discharge was rate and context dependent. The LTP-induced "remapping" occurred without affecting the global firing rate of the network. The findings support the view that learned place representation can be accomplished by LTP-like synaptic plasticity within intrahippocampal networks.

journal_name

Neuron

journal_title

Neuron

authors

Dragoi G,Harris KD,Buzsáki G

doi

10.1016/s0896-6273(03)00465-3

subject

Has Abstract

pub_date

2003-08-28 00:00:00

pages

843-53

issue

5

eissn

0896-6273

issn

1097-4199

pii

S0896627303004653

journal_volume

39

pub_type

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