Abstract:
:Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.
journal_name
Neuronjournal_title
Neuronauthors
Varoqueaux F,Aramuni G,Rawson RL,Mohrmann R,Missler M,Gottmann K,Zhang W,Südhof TC,Brose Ndoi
10.1016/j.neuron.2006.09.003subject
Has Abstractpub_date
2006-09-21 00:00:00pages
741-54issue
6eissn
0896-6273issn
1097-4199pii
S0896-6273(06)00680-5journal_volume
51pub_type
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