Abstract:
:The Drosophila circadian oscillator consists of interlocked period (per)/timeless (tim) and Clock (Clk) transcriptional/translational feedback loops. Within these feedback loops, CLK and CYCLE (CYC) activate per and tim transcription at the same time as they repress Clk transcription, thus controlling the opposite cycling phases of these transcripts. CLK-CYC directly bind E box elements to activate transcription, but the mechanism of CLK-CYC-dependent repression is not known. Here we show that a CLK-CYC-activated gene, vrille (vri), encodes a repressor of Clk transcription, thereby identifying vri as a key negative component of the Clk feedback loop in Drosophila's circadian oscillator. The blue light photoreceptor encoding cryptochrome (cry) gene is also a target for VRI repression, suggesting a broader role for VRI in the rhythmic repression of output genes that cycle in phase with Clk.
journal_name
Neuronjournal_title
Neuronauthors
Glossop NR,Houl JH,Zheng H,Ng FS,Dudek SM,Hardin PEdoi
10.1016/s0896-6273(03)00002-3subject
Has Abstractpub_date
2003-01-23 00:00:00pages
249-61issue
2eissn
0896-6273issn
1097-4199pii
S0896627303000023journal_volume
37pub_type
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